A method for preparing sucralose by continuous deacetylation of sucralose-6-acetate

A technology for preparing sucralose and sucralose by acetyl group, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems such as no continuous production, and achieves easy control of reaction temperature and saving. Production cost, effect of low sucralose content

Active Publication Date: 2016-06-29
FUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the reaction in the industry adopts batch operation, and there is no relevant report on continuous production.

Method used

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  • A method for preparing sucralose by continuous deacetylation of sucralose-6-acetate
  • A method for preparing sucralose by continuous deacetylation of sucralose-6-acetate
  • A method for preparing sucralose by continuous deacetylation of sucralose-6-acetate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The sucralose-6-acetate and the solvent methanol are prepared in a molar ratio of 1:40 to make a raw material solution, and the catalyst sodium methoxide and the solvent methanol are prepared in a molar ratio of 1:120 to make a catalyst solution. A reactor using oscillatory flow as a continuous production process.

[0025] Turn on the super constant temperature water tank and stabilize the temperature of the circulating water to 40°C. Turn on the raw material liquid delivery pump to continuously transport the raw material liquid to the oscillating flow reactor, and at the same time turn on the electromagnetic metering pump (ie the oscillating pump), adjust the oscillation frequency to 1Hz, and the oscillation amplitude to 0.02m. The reaction residence time was 30 min. When the height of the raw material liquid in the reactor reaches the height of the catalyst inlet, the catalyst delivery pump is turned on to transport the catalyst solution to the oscillating flow react...

Embodiment 2

[0028] According to the method of Example 1, the deacetylation reaction of sucralose-6-acetate is carried out, and the process conditions are as follows:

[0029]

[0030] In this reaction, the content of sucralose in the crude sucralose product was 97.15%, the conversion rate of sucralose-6-acetate was 93.5%, and the yield of sucralose was 85.1%.

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Abstract

The invention provides a method for preparing sucralose by continuously deacetylating sucralose-6-acetate. According to the method, in the presence of a basic catalyst, the sucralose-6-acetate is deacetylated to generate the sucralose, the catalyst is added in a segmented mode according to pH of a reaction solution, a novel reactor is adopted so that the catalyst can be rapidly mixed and dispersed, and the reaction temperature is easy to control. The synthetic sucralose has the advantages that residual quantity of the sucralose-6-acetate is small, the content of dichloro sucrose is low, the usage amount of the catalyst is small, the yield of the sucralose is high, continuous operation is achieved, the production cycle is shortened, and production cost is saved.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for continuously deacetylating sucralose-6-acetate to prepare sucralose. Background technique [0002] Sucralose is a new generation of sweeteners successfully developed in 1976 after aspartame and AK sugar. It has high sweetness, great sweetness, non-toxic and no side effects, is hardly absorbed in the human body, and has a calorific value close to Zero, good physical and chemical properties and a wide range of applications. Sucralose has the molecular formula C 12 h 19 o 8 Cl 3 , whose chemical name is 4,1’,6’-trichloro-4,1’,6’-tridechlorogalactosucrose. Sucralose is a white powder product that is easily soluble in water and has a sweetness 600 times that of sucrose. It is a new type of strong sweetener. [0003] Sucralose is made from sucrose by selectively replacing three positions of the eight hydroxyl groups of the sucrose molecule with chloride i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H5/02C07H1/00
Inventor 郑辉东黄秀娟赵素英吴丹
Owner FUZHOU UNIV
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