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Application of angiotensin converting enzyme inhibitor

An angiotensin-converting enzyme technology, applied in the field of biomedicine, to achieve the effects of enhancing insulin sensitivity, enhancing adaptability, and improving glucose tolerance

Inactive Publication Date: 2014-09-03
INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no studies on the use of angiotensin-converting enzyme inhibitors in the treatment of obesity and obesity-related diseases

Method used

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  • Application of angiotensin converting enzyme inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Fosinopril can inhibit obesity induced by high-fat diet

[0035] In order to verify the anti-obesity effect of ACE inhibitors, we prepared the following high-fat diet-induced obesity mouse model: 6-week-old C57BL / 6J male mice were fed with 60Kcal% high-fat diet (Research diet, D12451 ), and body weight was recorded weekly. After 8 weeks of induction and waiting for obesity, the high-fat diet-induced obesity group was randomly divided into obesity control group (HFD, 10 rats) and obese fosinopril group (HFD+ACEI, 14 rats); then the obese fosinopril group , treated with fosinopril, administered at an amount of 134mg / 10kg / day (equivalent to 1.34mg / kg body weight / day); and the obese control group and normal diet group (7, LFD, fed with 10Kcal% low Fat feed, Research diet, D12450B), treated with the same dose of starch, administered in the form of mixing into the feed, administered continuously, the average daily food intake of animals in each experimental group...

Embodiment 2

[0039] Example 2 Fosinopril can improve insulin resistance induced by high-fat diet

[0040] Many research results show that obesity is often accompanied by severe insulin resistance; therefore, we took the mice administered in Example 1 at the 9th week and carried out the following experiments:

[0041] 1. Intraperitoneal glucose tolerance test (IPGTT): The mice administered in Example 1 after 10 weeks were fasted overnight, weighed, and injected with glucose 1.5g / kg body weight intraperitoneally. The instrument measured the blood glucose at 0min, 15min, 30min, 45min, 60min, 90min and 120min respectively.

[0042] The result is as Figure 5As shown, the fasting blood glucose (8.51±1.46mM) of the obese control group induced by high-fat diet was significantly higher than that of the normal diet group (6.35±0.73mM), while fosinopril treatment could effectively restore the high-fat diet-induced hyperglycemia (6.83±0.98mM, p Image 6 As shown, it shows that fosinopril can signi...

Embodiment 3

[0046] Embodiment 3 fosinopril can improve energy consumption

[0047] The mice after the 10th week of administration in Example 1 were taken, and their oxygen consumption was detected by LabMaster of TSE Company, and they were respectively placed under the conditions of 25°C and 4°C, and the body temperature of the mice was measured.

[0048] The result is as Figure 8-9 As shown, it can explain the effect of fosinopril on body weight and insulin sensitivity. Depend on Figure 8 We can see that fosinopril increases the body's oxygen consumption, indicating that fosinopril improves the body's overall energy metabolism (p Figure 9 It shows that fosinopril can effectively improve the heating effect under cold stimulation (p<0.05).

[0049] In summary, Figure 8-9 The results suggest that fosinopril can increase the body's energy metabolism.

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Abstract

The invention provides an application of an angiotensin converting enzyme inhibitor, and in particular relates to the application of the angiotensin converting enzyme inhibitor in preparing medicine for treating obesity, obesity related diseases, improving energy metabolism or promoting heat generating. The experiment proves that the angiotensin converting enzyme inhibitor fosinopril treatment is capable of effectively inhibiting the obesity induced by high fat diet, treating insulin resistance induced by the high fat diet, improving the glucose tolerance dose of the organism by increasing the energy metabolism level of the organism, enhancing the insulin sensitivity of the tissue, and enhancing the adaptability of the organism to cold excitation by activating the organism to generate heat; and a new path for treating the obesity and related diseases is developed.

Description

technical field [0001] The invention relates to the field of biomedicine. The present invention specifically relates to an application of an inhibitor, in particular to an application of an angiotensin-converting enzyme inhibitor. Background technique [0002] The occurrence of obesity is the result of the body's energy metabolism disorder, that is, when the body's energy intake exceeds energy consumption, the remaining energy is almost completely converted into fat and stored in the white fat of the whole body. Obesity is an explosive epidemic worldwide. In my country, the obese population has accounted for 11.3% of the total population. Obesity induces many diseases including: type 2 diabetes, non-alcoholic fatty liver, gallstones, cardiovascular disease and Alzheimer's disease, and some are even a major risk factor for cancer. Obesity refers to a certain degree of obvious overweight and excessive fat layer. Due to excessive food intake or changes in body metabolism, ex...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/675A61P3/00A61P3/04A61P3/10A61P5/50
Inventor 金万洙刘晓萌黄园园
Owner INST OF ZOOLOGY CHINESE ACAD OF SCI
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