A fluorescent functional polymer nanosphere with dual response to temperature and pH, preparation method and application

A nano-microsphere and dual-response technology, which is applied in chemical instruments and methods, thermometers, fluorescence/phosphorescence, etc., can solve the problems of applicability limitations, deterioration of fluorescence performance, etc., and achieve the effect of good response function

Active Publication Date: 2016-03-02
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when traditional fluorescent materials are in concentrated solutions or thin films, the exciton fluorescence is quenched due to the molecular aggregation structure, resulting in poor fluorescence performance, which greatly limits their applicability.

Method used

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  • A fluorescent functional polymer nanosphere with dual response to temperature and pH, preparation method and application
  • A fluorescent functional polymer nanosphere with dual response to temperature and pH, preparation method and application
  • A fluorescent functional polymer nanosphere with dual response to temperature and pH, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh 4.42mmol of NIPAM monomer and dissolve it in 185mL deionized water, add it to a 500mL three-necked bottle, add 1.4×10 -6 mol of rare earth complex Eu(TTA) 3Phen, 5mL of styrene (St), at room temperature and under nitrogen protection, mechanically stirred (400rpm) for 30min, then gradually warmed up to 70°C, added 15mL of an aqueous solution containing 0.3mmol of initiator potassium persulfate (KPS) in the system, and initiated polymerization. The reaction was carried out for 12h to end. The resulting Eu(TTA) 3 Phen's seed polymer microspheres are centrifuged at high speed to remove impurities such as unpolymerized monomers and initiators in the liquid phase, and the product is dissolved in 100mL of deionized water for use.

[0024] (2) the polymer microsphere that step (1) is obtained continues to carry out seed emulsion polymerization, adds 40mmolNIPAM in the polymer seed microsphere solution that step (1) obtains, the AA of 3mmol, under room temperature a...

Embodiment 2

[0027] (1) Weigh 5 mmol of VCL monomer and dissolve it in 190 mL of deionized water, add it to a 500 mL three-necked bottle, add 2×10 -6 mol of RhB, 5mL of styrene (St), under the protection of nitrogen at room temperature, mechanically stir (400rpm) for 30min, gradually warm up to 70°C, add 10mL of an aqueous solution containing 0.3mmol of initiator ammonium persulfate (APS) into the system , triggering polymerization. The reaction was carried out for 12h to end. The obtained RhB-containing polymer seed microspheres. Impurities such as unpolymerized monomers and initiators in the liquid phase were removed by high-speed centrifugation, and the product was dissolved in 100 mL of deionized water for use.

[0028] (2) The polymer microsphere that step (1) is obtained continues to carry out seed emulsion polymerization, adds 40mmolVCL, the MAA of 3.2mmol in the polymer seed microsphere solution that step (1) obtains, under nitrogen protection at room temperature, mechanical Sti...

Embodiment 3

[0031] (1) Weigh 5 mmol of NVC monomer and dissolve it in 100 mL of deionized water, add it to a 500 mL three-necked bottle, add 1.5×10 -6 mol of CdTe, 5mL of fluorostyrene (F-St), under the protection of nitrogen at room temperature, mechanically stirred (400rpm) for 30min to remove the air in the system, then gradually raised the temperature to 70°C, added 10mL of initiator containing Sodium Sulfate (Na 2 S 2 o 8 ) 0.3mmol aqueous solution in the system to initiate polymerization. The reaction was carried out under nitrogen protection for 12h to end. CdTe-containing polymer seed microspheres were obtained. Impurities such as unpolymerized monomers and initiators in the liquid phase were removed by high-speed centrifugation, and the product was dissolved in 100 mL of deionized water for use.

[0032] (2) The polymer microspheres that step (1) obtains is continued to carry out seed emulsion polymerization, adds 45mmolNVC, the MAA of 3.5mmol in the polymer seed microsphere...

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Abstract

The invention relates to a fluorescence functional polymer nanometer microsphere with dual responsiveness to temperature and pH and a preparing method thereof and belongs to the field of polymer materials. According to the method, a traditional composite emulsion microsphere of a fluorescent molecular A is synthesized firstly, and by adoption the synthesized traditional composite emulsion microsphere as a seed and by adoption of a seeded emulsion polymerization method, a polymer with temperature responsiveness and pH responsiveness is introduced into the shell layer of the microsphere, thus preparing a core-shell-structure emulsion microsphere with dual responsiveness to temperature and pH. A fluorescent molecular B with an AIE characteristic is composited into the shell layer of the microsphere so as to obtain the fluorescence functional polymer nanometer microsphere with dual responsiveness to temperature and pH. The nanometer microsphere shows different fluorescent response properties to the temperature and the pH, and therefore the nanometer microsphere has a wide application prospect in the fields of microscopic fluorescence nanoscale thermometers, tumor cell and tissue detection, drug sustained release, and the like.

Description

technical field [0001] The invention belongs to the field of macromolecular materials, and relates to a fluorescent functional polymer nano-microsphere with dual responses to temperature and pH, a preparation method and an application in dual detection of microscopic temperature and pH. Background technique [0002] Stimuli-responsive polymer materials refer to polymers that can adapt to the surrounding environment, change and transform their chemical or physical properties according to changes in the local environment, and generate a certain executive ability. In recent years, stimuli-responsive polymer nanospheres have attracted extensive attention from researchers due to their small size and rapid response to external environmental stimuli. It has a wide range of applications in sensing and separation, microelectronics, coatings and textiles. In the research work on responsive polymer materials reported so far, the research on the responsive microsystem based on the temp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/54C08F212/08C08F220/06C08F226/06C08F212/14C08F2/44C09K11/06G01N21/64G01K11/00
Inventor 林权杨旭东陈洁陈阳孙源卿杨雪杨柏董凤霞
Owner JILIN UNIV
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