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Method for producing baicalin

A production method, the technology of baicalin, which is applied in the field of baicalin production, can solve the problems of rough process, waste, and low collection ratio of baicalin, and achieve the effects of high collection rate, improved collection rate, and optimized process parameters

Inactive Publication Date: 2014-09-10
施佩蓓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rough process of the current baicalin production method, the collection ratio of baicalin is low, resulting in a large amount of waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The present invention provides a kind of production method of baicalin, it is characterized in that, comprises the steps:

[0014] S1. Take 150g of Scutellaria baicalensis coarse powder, add 1.2kg of water at 90°C, and let stand for 20min;

[0015] S2. Filter with cotton, add 700 g of the residue to 90°C water, let stand for 20 minutes, and combine the filtrates;

[0016] S3. Add hydrochloric acid to adjust the pH value to 2, heat the acidic water solution in a water bath to 80°C, and let it stand for 30 minutes. When the supernatant liquid is clear, pour the supernatant liquid into another container, and rinse the lower sediment with 80°C water , to obtain crude total flavonoids;

[0017] S4. Put the crude total flavonoids in the Erlenmeyer flask, add ethanol to soak for several times, until the color of the ethanol infusion becomes lighter, and then add acetone to precipitate the resinous residue;

[0018] S5, reclaim the ethanol soaking solution and the acetone soa...

Embodiment 2

[0022] A kind of production method of baicalin, is characterized in that, comprises the steps:

[0023] S1. Take 150g of Scutellaria baicalensis root powder, add 1.2kg of water at 95°C, and let it stand for 20 minutes;

[0024] S2. Filter with cotton, add 700 g of the residue to 95°C water, let stand for 20 minutes, and combine the filtrates;

[0025] S3. Add hydrochloric acid to adjust the pH value to 2, heat the acidic water solution in a water bath to 80°C, and let it stand for 30 minutes. When the supernatant liquid is clear, pour the supernatant liquid into another container, and rinse the lower sediment with 80°C water , to obtain crude total flavonoids;

[0026] S4. Put the crude total flavonoids in the Erlenmeyer flask, add ethanol to soak for several times, until the color of the ethanol infusion becomes lighter, and then add acetone to precipitate the resinous residue;

[0027] S5, reclaim the ethanol soaking solution and the acetone soaking solution respectively, ...

Embodiment 3

[0031] The present invention provides a kind of production method of baicalin, it is characterized in that, comprises the steps:

[0032] S1. Take 150 g of Scutellaria baicalensis root powder, add 1.2 kg of water at 100°C, and let stand for 20 minutes;

[0033] S2. Filter with cotton, add 700 g of the residue to 100°C water, let stand for 20 minutes, and combine the filtrates;

[0034] S3. Add hydrochloric acid to adjust the pH value to 2, heat the acidic water solution in a water bath to 80°C, and let it stand for 30 minutes. When the supernatant liquid is clear, pour the supernatant liquid into another container, and rinse the lower sediment with 80°C water , to obtain crude total flavonoids;

[0035] S4. Put the crude total flavonoids in the Erlenmeyer flask, add ethanol to soak for several times, until the color of the ethanol infusion becomes lighter, and then add acetone to precipitate the resinous residue;

[0036] S5, reclaim the ethanol soaking solution and the acet...

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PUM

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Abstract

The invention provides a method for producing baicalin. The method includes the step S1 of taking 150 grams of scutellaria baicalensis root coarse powder, adding 1.2 kilograms of water with the temperature ranging from 90 DEG C to 100 DEG C and standing for 20 min, the step S2 of conducting filtering, adding 700 grams of water with the temperature ranging from 90 DEG C to 100 DEG C to residues, standing for 20 min, and combining the mixture with filter liquor, the step S3 of adding hydrochloric acid to regulate the pH value to be 2, conducting water-bath heating till the temperature reaches 80 DEG C, standing for 30 min, and washing sediment on the lower layer with water at the temperature of 80 DEG C to obtain coarse total flavones, the step S4 of adding ethyl alcohol to the coarse total flavones, and adding acetone to wash the mixture so as to obtain resin-shaped residues, the step S5 of recycling the ethyl alcohol soak solution and the acetone soak solution, wherein the matter which is not dissolved in the ethyl alcohol and the acetone is the crude product of baicalin, and the step S6 of adding ethyl alcohol to the coarse product of baicalin, conducting water bath for 30 min, conducting filtering, adding methyl alcohol, and conducting crystallization, filtering and drying to obtain baicalin. The method is high in baicalin collection rate, and by improving the process, the collection rate is increased and process parameters are optimized.

Description

technical field [0001] The invention relates to a production method of baicalin, in particular to a production method of baicalin by using the root powder of Scutellaria baicalensis. Background technique [0002] Baicalin is extracted from the dried root of Scutellaria baicalensis, a dicotyledonous plant. Scutellaria baicalensis is a commonly used traditional Chinese medicine. Baicalin is a flavonoid compound extracted from the root of Scutellaria baicalensis, which has significant biological activity, antibacterial, diuretic, anti-inflammatory, anti-allergic and antispasmodic effects, and has strong physiological effects such as anti-cancer response . It has occupied an important position in clinical medicine. Baicalin can also absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the formation of melanin, so it can be used in both medicine and cosmetics, and is a good raw material for functional cosmetics. The current baicalin preparation method has a low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 施佩蓓
Owner 施佩蓓
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