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Use of epigallocatechin gallate (EGCG) in preparation of food and drug for preventing and treating myocardial energy metabolism disorders

A technology of energy metabolism and myocardium, applied in the fields of nutrition, pharmacy, and biology, can solve the problems of lack of prevention and treatment methods, and no research reports on the improvement of EGCG, so as to prevent and treat myocardial glucose metabolism disorders, improve myocardial function, and ensure safety. sex high effect

Inactive Publication Date: 2014-09-17
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although many studies have revealed the important role of green tea, especially its main component EGCG, in diabetes and cardiovascular diseases, there is no research report on whether EGCG can improve myocardial damage and myocardial energy metabolism disorders
In particular, does EGCG improve myocardial energy dysbolism? Mitochondria are the key organelles of myocardial energy metabolism. Does EGCG prevent myocardial glucose metabolism disorders by improving mitochondrial function? Myocardial glucose and lipid metabolism disorder is a common early pathological feature of myocardial insufficiency, coronary heart disease and other cardiovascular diseases, and is also one of the important complications of metabolic diseases such as diabetes. At present, there is a lack of effective prevention and treatment methods

Method used

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  • Use of epigallocatechin gallate (EGCG) in preparation of food and drug for preventing and treating myocardial energy metabolism disorders
  • Use of epigallocatechin gallate (EGCG) in preparation of food and drug for preventing and treating myocardial energy metabolism disorders
  • Use of epigallocatechin gallate (EGCG) in preparation of food and drug for preventing and treating myocardial energy metabolism disorders

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Effect test

Embodiment 1

[0056] Therapeutic effect of EGCG on mitochondrial dysfunction in the heart of GK rats with impaired glucose metabolism

[0057] Proteins and mitochondria were extracted from the hearts of normal Wistar rats, myocardial glucose metabolism disorder model GK rats and EGCG-fed GK rats, respectively, and then the expression levels of mitochondria-related proteins were detected by western blotting. The results are shown in figure 1 A, the expression of mitochondria-related proteins; figure 1 B expression of mitochondria-related proteins (statistical results). The expression levels of mitochondrial respiratory chain complex and VDAC1 in the heart of GK rats were decreased, but EGCG had a good recovery effect on them. The enzyme activity of mitochondria-related enzymes was detected by enzyme activity assay. figure 1 C, EGCG has a significant effect on increasing the enzymatic activities of mitochondrial respiratory chain complex enzymes (I, III) and α-ketoglutarate dehydrogenase com...

Embodiment 2

[0059] Restorative effect of EGCG on the upregulation of biphasic enzyme expression in the heart of GK rats.

[0060] The expression of biphasic enzymes is an important indicator of the antioxidant system in the body, and its increase can also reflect the increase in oxidative stress in the body. Proteins were extracted from the hearts of normal Wistar rats, GK rats with impaired glucose metabolism, and EGCG-fed GK rats, respectively, and the expression of biphasic enzymes was detected by western blotting. from figure 2 It can be seen that the expression of biphasic enzymes (NQO1, HO1, MnSOD) in the hearts of GK rats was significantly up-regulated compared with Wistar rats, and the feeding of EGCG could effectively reduce the expression of biphasic enzymes.

Embodiment 3

[0062] Effects of EGCG on the expression of mitochondrial production and dynamics-related proteins in the heart of GK rats.

[0063] We found that mitochondria in the hearts of GK rats had dysfunction and decreased numbers, and speculated that these phenomena may be related to mitochondrial generation and dynamic changes. from image 3 It can be seen from A and 3B that the expression of mitochondrial production-related proteins in the heart of GK rats has increased, and the feeding of EGCG has a recovery effect on it; image 3 It can be seen from C and 3D that the mitochondrial fusion-related protein in the heart of GK rats did not change, but the fission-related protein Drp1 was reduced, and EGCG was able to restore its expression level to normal rat Wistar.

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Abstract

The invention discloses a use of epigallocatechin gallate (EGCG) in preparation of a food and a drug for preventing and treating myocardial energy metabolism disorders. An EGCG action target is an intracellular FoxO1 signal channel. EGCG can inhibit myocardial energy metabolism disorders-caused myocardial cell autophagy and relieve myocardial mitochondria loss. EGCG has an effective concentration of 20 micromoles per liter to myocardial cells, or based on individual weight, an intake ratio of EGCG is 5-10mg / kg / day. EGCG can adjust a myocardial energy metabolism capacity, recover energy metabolism disorders-caused myocardial cell incompetence, inhibit myocardial cell H9c2 glycometabolism disorders-related autophagy increasing, inhibit myocardial cell H9c2 glycometabolism disorders-related oxidative stress, and reduce myocardial cell H9c2 glycometabolism disorders-related insulin resistance. EGCG as a food functional factor and a drug can be used for preventing and treating diseases such as myocardial damage caused by myocardial energy metabolism disorders, myocardial insulin resistance and hyperglycemia.

Description

technical field [0001] The invention relates to the fields of biology, nutrition and pharmacy, in particular to the application of epigallocatechin gallate (EGCG) in preparing food and medicine for preventing and treating myocardial energy metabolism disorder. Background technique [0002] The normal functioning of the heart muscle requires a steady, continuous supply of energy. Myocardial energy metabolism dysfunction refers to the decline in the ability of the myocardium to utilize glucose and fatty acids, resulting in disturbance of energy supply, resulting in insufficiency of myocardial cells, which in turn affects the normal beating of the heart. Myocardial energy metabolism dysfunction is not only one of the early common pathological features of important cardiovascular diseases such as myocardial insufficiency and coronary heart disease, but also one of the important complications of metabolic diseases such as diabetes. Prevention and treatment of myocardial energy m...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P9/00A61P5/50A61P3/10A23L1/29A23L33/00
Inventor 刘健康龙建纲刘甲唐颖冯智辉严炯
Owner XI AN JIAOTONG UNIV
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