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Domperidone oral solid dosage form

A technology of domperidone and solid preparation, which is applied in the field of pharmaceutical preparations to achieve the effects of improving dependence, reducing toxic and side effects, and reducing dosage

Active Publication Date: 2014-09-24
南京康川济医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report on whether the compound has the effect of promoting digestion

Method used

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  • Domperidone oral solid dosage form
  • Domperidone oral solid dosage form
  • Domperidone oral solid dosage form

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]

[0017]

[0018] Preparation process: first pass domperidone, orange cassiatin and all auxiliary materials through a 100-mesh sieve, and set aside; weigh the prescribed amount of mannitol, starch, carboxymethyl starch sodium, pass through a 80-mesh sieve and mix with the main ingredients, and mix them with 0.15N Sodium hydroxide aqueous solution is used as a binder to make a soft material, granulated with a 16-mesh sieve, dried at 65°C for 1 hour, and granulated with a 16-mesh granule; weigh the prescribed amount of magnesium stearate, mix it with the dry granules, and press into tablets.

Embodiment 2

[0020]

[0021] Preparation process: pass domperidone, orange cassiatin and all auxiliary materials through a 100-mesh sieve respectively, and set aside; weigh the prescribed amount of lactose, microcrystalline cellulose, and crospovidone, pass through a 80-mesh sieve and mix with the main ingredients. 0.15N sodium hydroxide aqueous solution is used as a binder to make a soft material, granulated with a 16-mesh sieve, dried at 65°C for 1 hour, and granulated with a 16-mesh; weigh the prescribed amount of magnesium stearate, mix it with the dry granules, and press into tablets. have to.

Embodiment 3

[0023]

[0024]

[0025] Preparation process: first pass domperidone, orange cassiatin and all auxiliary materials through a 100-mesh sieve, and set aside; weigh the prescribed amount of mannitol, starch, carboxymethyl starch sodium, pass through a 80-mesh sieve and mix with the main ingredients, and mix them with 0.15N Sodium hydroxide aqueous solution is used as a binder to make a soft material, granulated with a 16-mesh sieve, dried at 65°C for 1 hour, and granulated with a 16-mesh granule; weigh the prescribed amount of talcum powder, mix it with the dry granules, and fill the capsule shell.

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PUM

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Abstract

The invention discloses a domperidone oral solid dosage form. According to the domperidone oral solid dosage form, domperidone, orange obtusin, filler, disintegrating agents, alkaline adhesion agents and lubricating agents are made into troches and capsules. The dosage of the domperidone is reduced, the aid digestion effect of the domperidone oral solid dosage form is enhanced, and therefore the toxic and side effect of the domperidone oral solid dosage form is greatly reduced and an improvement on long-term medication dependency of a patient is facilitated.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a domperidone oral solid preparation. Background technique [0002] Domperidone (domperidone) is a synthetic benzoimidazole derivative, similar in structure to propyl ketone phenyl. It is a dopamine receptor antagonist with anti-emetic effect, and it is not easy to enter the brain through the blood-brain barrier. Domperidone acts on the chemoreceptor trigger area outside the blood-brain barrier, so it hardly acts on the central nervous system; domperidone selectively blocks dopamine 2 (DA2) receptors and mainly acts on the peripheral nervous system. Since DA2 receptors are also the main receptors in the gastrointestinal tract, DA2 receptor antagonists reduce dopamine-mediated relaxation of gastric smooth muscle. In the gastrointestinal tract, domperidone, as a prokinetic drug, can increase the motility of the digestive tract and can be used to prevent gastro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P1/14A61P1/04A61P1/08A61K31/122
Inventor 王菊明
Owner 南京康川济医药科技有限公司
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