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Method for extracting capsaicin from chili extract by using double phase extraction technology

An extraction technology, capsicum extract technology, applied in the field of biomedicine, can solve the problems of low extraction rate, large one-time investment, unsuitable for industrial production, etc., and achieve the effect of increasing extraction rate, reducing dosage, and shortening extraction time

Active Publication Date: 2014-09-24
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods either have the disadvantages of low extraction rate and are not suitable for industrialized production, or although the operation is simple, the one-time investment is too large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Dissolve solid potassium carbonate accounting for 25% of the total mass of the two-phase system in a Brattan-Robison buffer solution with a pH of 2 at 25°C, and add analytically pure ethanol after the dissolution is complete so that the ethanol content is 18% of the total mass of the two-phase aqueous system, mixed evenly to form a two-phase aqueous system.

[0024] (2) Take capsicum extract accounting for 3% of the total mass of the two-phase system and add it to the ethanol-potassium carbonate two-phase system, place it in a shaker and shake for 30 minutes.

[0025] (3) Centrifuge the two-phase extraction system for 10 minutes, take out the capsaicin-rich ethanol upper phase and concentrate it in a distillation flask under reduced pressure.

[0026] (4) The obtained concentrated solution under reduced pressure was dried in a vacuum oven for 24 hours to obtain solid capsaicin. The obtained capsaicin solid was dissolved in 70% methanol to analyze the content of cap...

Embodiment 2

[0028] (1) Dissolve solid potassium carbonate, which accounts for 30% of the total mass of the two-phase system, in a Brattan-Robison buffer solution with a pH of 3 at 25°C. After the dissolution is complete, add analytically pure ethanol so that the ethanol content is 25% of the total mass of the two-phase aqueous system, mixed evenly to form a two-phase aqueous system.

[0029] (2) Add capsicum extract, which accounts for 4% of the total mass of the two-phase system, into the ethanol-potassium carbonate two-phase system, and place it in a shaker for oscillating extraction for 50 minutes.

[0030] (3) Centrifuge the two-phase extraction system for 10 minutes, take out the capsaicin-rich ethanol upper phase and concentrate it in a distillation flask under reduced pressure.

[0031] (4) The obtained concentrated solution under reduced pressure was dried in a vacuum oven for 24 hours to obtain solid capsaicin. The obtained capsaicin solid was dissolved in 70% methanol to analyz...

Embodiment 3

[0033] (1) Dissolve solid potassium carbonate accounting for 20% of the total mass of the two-phase system in a Brattan-Robison buffer solution with a pH of 2 at 25°C, and add analytically pure ethanol after the dissolution is complete so that the ethanol content is 20% of the total mass of the two-phase aqueous system, mixed uniformly to form a two-phase aqueous system.

[0034] (2) Add capsicum extract, which accounts for 3% of the total mass of the two-phase system, into the ethanol-potassium carbonate two-phase system, and place it in a shaker for oscillating extraction for 60 minutes.

[0035] (3) Centrifuge the two-phase extraction system for 10 min, take out the capsaicin-rich ethanol upper phase and concentrate it in a distillation flask under reduced pressure.

[0036] (4) The obtained concentrated solution under reduced pressure was dried in a vacuum oven for 24 hours to obtain solid capsaicin. The obtained capsaicin solid was dissolved in 70% methanol to analyze th...

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Abstract

The invention belongs to the biological medicine field, and especially discloses a method for extracting capsaicin from chili extract by using a double phase extraction technology. The method takes capsaicin as a raw material, and is characterized in that a proper amount of capsaicin is taken, a double water phase system of ethanol and potassium carbonate is added, uniformly mixed, divided into an upper phase and a lower phase; ethanol phase containing a lot of capsaicin is taken, steps of underpressure distillation and condensation are carried out, vacuum drying is carried out, then solid capsaicin is obtained. The method can be carried out at normal temperature, extraction rate of capsaicin can be increased, the used organic solvent is little, the method is economic and operation is simple, and the method is suitable for industrial production.

Description

(1) Technical field [0001] The invention belongs to the field of biomedicine, in particular to a method for extracting capsaicin from capsicum essence by using a two-phase extraction technique. (2) Background technology [0002] The spicy ingredients in capsicum fruit are a class of capsaicinoids mainly capsaicin, which are: capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and p-methyl capsaicin, p-methyl capsaicin, p- Methyl capsaicin chain, p-methyl capsaicin saturated chain hydrocarbon, p-tolyl capsaicin, etc., among which capsaicin is the main one, and capsaicin and dihydrocapsaicin account for about 90% of the total above. Capsaicin has pharmacological effects such as analgesia, anti-inflammatory, appetite-stimulating, digestion-improving, antibacterial and insecticidal, and selectivity to neurotransmitters. Based on the properties of capsaicin easily soluble in organic solvents and alkaline solutions, the extraction of capsaicin mainly includes organic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/20C07C231/24
Inventor 崔波赵培培檀琮萍卢艳敏
Owner QILU UNIV OF TECH