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Composition for enhancing memory and application thereof

A technology for enhancing memory and composition, applied in the fields of biomedicine and food health care, can solve the problem of not improving memory, etc., and achieve the effects of improving spatial memory ability, reducing expression, and prolonging error latency.

Active Publication Date: 2014-10-08
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compounding of multiple biologically active substances can often further improve its effect, but so far, no studies have been reported on the use of compound polysaccharides of versicolor polysaccharides and ginkgo biloba flavonoids to improve memory

Method used

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  • Composition for enhancing memory and application thereof
  • Composition for enhancing memory and application thereof
  • Composition for enhancing memory and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The application principle of the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0027] 1. Purpose of the experiment

[0028] To observe the combined oral administration of Yunzhi polysaccharide and ginkgo flavonoids on the improvement of memory in dementia model mice.

[0029] 2. Experimental materials

[0030] 1. Test drug

[0031] Yunzhi polysaccharide: polysaccharide content: 30wt.%

[0032] Ginkgo flavonoids: flavonoid content: 25wt.%

[0033] Positive control drug: galantamine hydrobromide (Xi'an Janssen Pharmaceutical Co., Ltd., specifications: 28 tablets / box, 8mg / tablet, batch number: 111012730, indications: for the treatment of mild to moderate Alzheimer's dementia symptom.)

[0034] 2. Experimental animals

[0035] 2.1 Source, species, strain, certificate: Yangzhou University Comparative Medicine Center, 96 clean-grade ICR mice, animal certificate number: SCXK (Su) 2012-0004.

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Abstract

The invention relates to a composition for enhancing memory and application thereof. The effective components of the composition are coriolus versicolor polysaccharide and ginkgo flavone. Medical fungus coriolus versicolor polysaccharide and flavonoid chemical compounds in natural medical plant ginkgo leaves are respectively extracted. When the coriolus versicolor polysaccharide and the ginkgo flavone are in drug combination,, the escape latent period of a demented mouse can be significantly shortened, the space memory ability is improved, the number of times of right reaction is increased, the latent period of making mistakes for the first time is prolonged, the number of times of mistakes is decreased, an abnormal state of brain tissue cells is alleviated, the expression of glial fibrillary acidic proteins (GFAP) is significantly reduced, and the composition has a definite improvement effect on the memory of a demented model mouse.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and food health care, and in particular relates to a memory-enhancing composition and its application. Background technique [0002] Alzheimer's disease, mainly manifested as Alzheimer's disease (AD), or dementia, is a persistent neurological dysfunction. AD is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. The main pathological features are brain atrophy, senile plaques in brain tissue, cerebral vascular deposits and neurofibrillary tangles. In the later stage, the cholinergic function in some parts of the central nervous system is mainly insufficient, so cholinergic enhancing drugs are currently the main therapeutic drugs, such as cholinesterase inhibitors donepezil, huperzine A, galantamine, rivastigmine, etc. However, cholinesterase (AChE) inhibitors are only a palliative treatment strategy that can tem...

Claims

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Application Information

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IPC IPC(8): A23L1/09A23L1/28A61K36/16A61P25/28A61K31/715
CPCA23L29/30A23L33/00A23V2002/00A61K31/715A61K36/16A23V2200/30A61K2300/00
Inventor 赵林果房仙颖姜艳曹福亮裴建军吴彩娥王佳宏张旭晖
Owner NANJING FORESTRY UNIV