Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof

A nano drug carrier and magnetocaloric effect technology, applied in the field of medicine, can solve the problems of reducing drug efficacy, poor selectivity of chemotherapy drugs, killing normal cells, etc., achieve good delivery efficiency, increase storage capacity, and reduce complications

Inactive Publication Date: 2014-10-08
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug chemotherapy is a common method in cancer treatment, but many chemotherapy drugs have poor selectivity and are difficult to specif

Method used

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  • Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof
  • Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof
  • Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034]

[0035] The nano-medicine carrier provided in this embodiment includes mesoporous silica particles and Fe embedded in the mesoporous silica particles. 3 O 4 Nano particles. The preparation method of the nano medicine carrier includes the following steps:

[0036] Step 1: Take FeCl 3 ·6H 2 O and FeCl 2 ·4H 2 Each 19.2 mmol of O was dissolved in 25 ml of deionized water and then 0.85 ml of concentrated hydrochloric acid (36-38%) was added; then 250 ml of 1.5 mol / L sodium hydroxide solution was added dropwise to the above solution, and Stir at 700 rpm for 1 hour at room temperature, resulting in a black precipitate.

[0037] Step 2: Collect the black precipitate with a magnet block, wash the black precipitate with deionized water three times, and then wash three times with ethanol, and finally vacuum dry at 60°C for 24 hours to obtain Fe 3 O 4 Nano particles.

[0038] Step 3: Take 0.4g Fe 3 O 4 Nanoparticles were dispersed in 36 ml of ultrapure water by ultrasound, 0.6836 g of ...

Example Embodiment

[0044]

[0045] The nano drug carrier provided in this embodiment is an amino-modified nano drug carrier, the silane coupling agent used is γ-aminopropyltriethoxysilane, and the preparation method is:

[0046] Take 1 gram of the nano drug carrier prepared in Example 1, ultrasonically disperse it in absolute ethanol to obtain a suspension, then quickly add 3 ml of γ-aminopropyltriethoxysilane to the above suspension, seal the container and stir at room temperature for 24 hours After hours, the unreacted γ-aminopropyltriethoxysilane was washed away with absolute ethanol and dried in vacuum to obtain the amino-modified nano-medicine carrier.

[0047] The particle diameter of the amino-modified nano-medicine carrier is about 150 nanometers, and the average mesoporous pore diameter of the mesoporous silica particles is 3.2 nanometers.

[0048] In addition, the silane coupling agent used in this embodiment is γ-aminopropyltrimethoxysilane. The outer surface of the mesoporous silica particl...

Example Embodiment

[0049]

[0050] The nano-medicine carrier provided in this embodiment is an RBITC-modified nano-medicine carrier, which is used to observe the uptake of the nano-medicine carrier by a cell under a fluorescence microscope. The silane coupling agent used is RBITC-APTES silane coupling agent, and its preparation method is:

[0051] Take 15 mg of Rhodamine B isothiocyanate (RBITC) and 100 μl of γ-aminopropyltriethoxysilane, add 5 ml of absolute ethanol, and stir in a sealed container under dark room conditions for 24 After hours, a rhodamine B modified silane coupling agent (RBITC-APTES) was obtained.

[0052] Then, take 20 mg of the nano-medicine carrier prepared in Example 1, and disperse it in 6 ml of absolute ethanol, add 1 ml of RBITC-APTES silane coupling agent, and stir for 24 hours in a sealed container under dark room conditions. Finally, the above-mentioned particle solution is centrifuged, and washed with anhydrous ethanol several times to remove the unreacted RBITC-APTES s...

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Abstract

The invention provides a nano-medicinal carrier with magnetocaloric effect. The nano-medicinal carrier with grain diameter of 50-200 nanometers comprises mesoporous silica particles and Fe3O4 nano-particles embedded inside the mesoporous silica particles, wherein the mesoporous diameter of the mesoporous silica particles is 2-10 nanometers, and the mesoporous channel is in a radial shape from the inner core to outside; the diameter of the Fe3O4 particles is 15-20 nanometers. The invention further provides a preparation method of the nano-medicinal carrier and application of the nano-medicinal carrier in loading anti-cancer medicaments. The nano-medicinal carrier is high in drug storage capacity, and can be used for remarkably improving the anti-cancer drug high-performance transmission efficiency, remarkably improving the curative effect of tumor treatment, and realizing cancer therapy by virtue of medical chemotherapy and magnetocaloric therapy.

Description

technical field [0001] The invention relates to a nano-medicine carrier with magnetocaloric effect, a preparation method of the nano-medicine carrier and an application of the nano-medicine carrier, belonging to the technical field of medicine. Background technique [0002] At present, the incidence of cancer in the world shows a sharp upward trend, and the main methods of clinical treatment of cancer at home and abroad are surgery, radiotherapy, hyperthermia and drug chemotherapy. Drug chemotherapy is a common method in cancer treatment, but many chemotherapy drugs have poor selectivity and are difficult to specifically reach cancer cells, which not only reduces the efficacy of drugs, but also has a greater killing effect on many normal cells. [0003] In order to improve the therapeutic effect of cancer, combination therapy is generally used at present, and different cancer treatment methods are applied to the same tumor site at the same time, and the combination of drug c...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/04B82Y5/00A61K45/00A61P35/00
Inventor 朱钰方陶翠莲
Owner UNIV OF SHANGHAI FOR SCI & TECH
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