Medical contrast agent containing unsaturated polymer

Abstract

The invention discloses a medical contrast agent containing unsaturated polymer. A microsphere, namely the medical contrast agent is of a hollow inorganic / organic / inorganic three-layer structure, a cavity is formed in the center of the microsphere, and air is filled inside the cavity; the outer layer of the cavity is provided with alpha-Fe2O3 magnetic particles; the intermediate layer is a core / shell polymer nanomicrosphere which is obtained by copolymerizing a polybutadiene-polyacrylic acid random copolymer, polyacrylic acid and divinyl benzene by means of free radicals, and the copolymer is stable because a coordinate bond or ionic bond can be formed between the copolymer and the alpha-Fe2O3 magnetic particles on the inner layer through carboxyl and ferric salt on the inner surface; the outer layer is silicon dioxide, and is connected with the silicon hydroxyl on the surface of the silicon dioxide through carboxyl on the surface of the microsphere by generating a hydrogen-bond interaction with the silicon hydroxyl on the surface of the silicon dioxide. The medical contrast agent has the advantages that the copolymer microsphere belongs to nano-grade particles, targeted location of the contrast agent can be realized by means of the alpha-Fe2O3 magnetic particles on the inner layer, the silicon dioxide hollow microsphere has good biocompatibility and mechanical stability, and the inner cavity can generate a strong echo signal under a radiography mode.

Description

technical field [0001] The invention relates to a contrast agent for medical detection, in particular to a multilayer organic / inorganic composite structure nano microsphere with magnetic function, which belongs to the field of medical technology. Background technique [0002] In recent years, molecular imaging technology has attracted extensive attention because it can provide important information for the diagnosis and monitoring of diseases in living tissues (Campbell R. E., Chang C. J. Curr Opin Chem Biol , 2010, 14(1):1-2.). Among many imaging modes, ultrasound imaging, as a non-invasive biomedical imaging mode, has important research value due to its advantages of safe and timely imaging and diagnosis, low price, lightness and quickness, and wide application. However, the difference in echo signals between different biological tissues often hinders the accuracy of diagnosis. In order to better obtain accurate information of specific tissues, people usually use the meth...

AI Technical Summary

Problems solved by technology

However, this method still has certain limitations, such as hollow SiO 2 The size of the spheres is too large and does not reach the nanoscale structure, which makes it difficult to be used for in vivo imaging, and it is difficult to carry out further connection without functional group modification

Therefore, the contrast agents currently used in clinical practice cannot simultaneously meet the requirements of good biocompatibility, mechanical stability, targeting performance, nanostructure, and functional group modification.

Images