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Halogenated artemisinin mother nucleus, halogenated artemisinin derivatives, halogenated dihydroartemisinin and halogenated decarbonylation artemisinin and medical use thereof

A technology of artemisinin derivatives and dihydroartemisinin, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., to achieve the effect of improving the treatment situation and rapid treatment effect

Inactive Publication Date: 2014-10-08
唐心建
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these inventions, the activity of artemisinin itself did not make a substantial breakthrough, and the activity was only slightly improved. Therefore, many intellectual property rights of artemisinin derivatives were eventually abandoned.

Method used

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  • Halogenated artemisinin mother nucleus, halogenated artemisinin derivatives, halogenated dihydroartemisinin and halogenated decarbonylation artemisinin and medical use thereof
  • Halogenated artemisinin mother nucleus, halogenated artemisinin derivatives, halogenated dihydroartemisinin and halogenated decarbonylation artemisinin and medical use thereof
  • Halogenated artemisinin mother nucleus, halogenated artemisinin derivatives, halogenated dihydroartemisinin and halogenated decarbonylation artemisinin and medical use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0102] Dosage content

[0103] The oral dosage forms mentioned include: drop pills, quick-release drop pills, capsules, granules, sprays, oral

[0104] Liquid, tablet, powder (powder), ointment, etc.; matrix sustained-release preparations include: (1) insoluble (such as ethyl cellulose EC, polyethylene, polypropylene, polysiloxane, ethylene-vinyl acetate copolymer, (polymethyl methacrylate, etc.); (2) waxy skeleton (such as fat, waxy substances, stearic acid, stearyl alcohol, glyceryl monostearate, carnauba wax, stearyl alcohol, etc. ); (3) Hydrophilic gel (such as CMC, CMC-Na, MC, PVA, HEC, HCMC, sodium alginate, pectin, alginate, agar, hydroxypropyl methylcellulose HPMC, deacetylated shell polysaccharide, chitin, galactomannan, etc.); (4) gastric retention tablets, etc.; sustained-release coating preparations include (1) membrane-controlled release tablets, (2) microporous membrane-coated tablets, (3) small tablets Pills include: film-controlled pellets, skeleton pe...

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PUM

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Abstract

The invention discloses a halogenated artemisinin mother nucleus, halogenated artemisinin derivatives, halogenated dihydroartemisinin and halogenated decarbonylation artemisinin and medical use thereof. According to the halogenated artemisinin mother nucleus, the halogenated artemisinin derivatives, the halogenated dihydroartemisinin and the halogenated decarbonylation artemisinin, a peroxide bridge in the halogenated artemisinin mother nucleus is completely released under the allowable condition.

Description

technical field [0001] The present invention relates to halogenated artemisinin, halogenated dihydroartemisinin, halogenated decarboxylated artemisinin and halogenated artemisinin derivatives and their medical application. Background technique [0002] In recent decades, scientists from all over the world have conducted extensive research on the anticancer effects and antiviral effects of artemisinin and its derivatives. Reports and papers are springing up everywhere, and the results all point to the fact that the derivatives of artemisinin (dihydroartemisinin) have broad prospects in the treatment of cancer and anti-virus, and have the advantages of rapid onset, minimal side effects and long treatment time. In the shortest case the problem of treating cancer may finally be solved. [0003] So far, scientists from various countries have conducted a lot of research in order to improve the activity of artemisinin. For this reason, they have created countless types of arte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/20A61K31/357A61K31/4184A61K31/4192A61K31/4196A61P35/00A61P31/04
CPCC07D493/20
Inventor 唐心建
Owner 唐心建