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Medicine for inhibiting appetite prepared from berberine

A technique for suppressing appetite and berberine, which is applied in the fields of biomedicine and physiology, can solve problems such as mental and psychological side effects, lack of sufficient long-term clinical effectiveness verification, withdrawal, etc., and achieve the effect of lowering blood sugar and blood lipids

Inactive Publication Date: 2014-10-15
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many appetite-suppressing drugs have been withdrawn due to failure to meet approval standards or serious adverse reactions found after marketing
The cannabinoid-receptor antagonist rimonabant (rimonabant) was not approved by the US Food and Drug Administration (FDA) and withdrawn from the European market because of the increased risk of depression and anxiety. The food center is intertwined with other regulatory centers in the brain, so the application may cause unpredictable mental and psychological side effects. In addition, the serotonin system agonists sibutramine and fenfluramine also have unacceptable side effects And the lack of sufficient long-term clinical effectiveness verification, it is limited in clinical use

Method used

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  • Medicine for inhibiting appetite prepared from berberine
  • Medicine for inhibiting appetite prepared from berberine
  • Medicine for inhibiting appetite prepared from berberine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Effect of berberine on food intake and body weight of db / db mice

[0024] After one week of adaptive feeding with common diet, the db / db mice were randomly divided into vehicle control group (Vehicle) and berberine intervention group (BBR), and were calibrated according to body weight and fasting blood glucose. Drug intervention was given after grouping, and the berberine intervention group was given 5mg*kg -1 *d -1 Berberine injection was injected intraperitoneally, and the blank solvent control group was given intraperitoneal injection of control solvent.

[0025] Preparation of berberine injection: DMSO was sonicated for 15 minutes with a sonicator, then polyethylene glycol (PEG) 400 was added, after being sonicated for 15 minutes, normal saline was added, and then 15 minutes of sonication was used as a contrast solvent (Vehicle ), wherein the volume ratio of DMSO, polyethylene glycol and saline is 1:20:79. Dissolve berberine in the above solvent and sti...

Embodiment 2

[0030] The random blood glucose and insulin of the mice were detected before administration (0 week), 1 week, 2 weeks, 3 weeks and 4 weeks after administration. The result shows, as image 3 As shown, there was no significant difference in the random blood glucose of the two groups of mice before administration, but as the experiment progressed, the blood glucose of the mice in the control group gradually increased, while the blood glucose measurement of the mice in the BBR treatment group (berberine intervention group) showed a gradual increase. There was a significant difference in the blood glucose of the two groups of mice by statistical analysis at 2 weeks of administration, and the difference gradually increased at 3 and 4 weeks.

[0031]Insulin tolerance test (ITT) was carried out at the 2nd week after administration: after the mice were fasted for 6 hours, insulin (2U / Kg body weight) was injected intraperitoneally, and passed through the tail vein at 0, 15, 30, 45, 60,...

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Abstract

The invention relates to the fields of biological medicine and physiology, and relates to application of berberine in the aspect of pharmacy, in particular to a medicine for inhibiting appetite prepared from berberine. The medicine can be used for reducing food intake amount of a diabetes mellitus patient or an obesity patient. As berberine is low in side effect, and can reduce blood sugar and blood fat, the medicine provides new direction for treating type-II diabetes mellitus and obesity.

Description

technical field [0001] The invention relates to the fields of biomedicine and physiology, in particular to the application of berberine in pharmaceuticals, especially for the preparation of drugs for suppressing appetite. Background technique [0002] With the continuous improvement of people's living standards, obesity and related diseases such as type 2 diabetes mellitus (T2DM), cardiovascular and cerebrovascular diseases, etc., which were previously common in western developed countries and related to energy metabolism, are now increasingly threatening the Chinese population. important diseases of health. According to statistics, the incidence rates of overweight and obesity among Chinese adults are 30.6% and 12.0% respectively. Such a high morbidity rate and various serious complications make the prevention and treatment of obesity a national problem. [0003] Patients with T2DM are prone to complications of macrovascular lesions such as hypertension and atherosclerosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P3/04
Inventor 宁光张会志王卫庆张志国
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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