Coxsackie virus A16 virus strain, uses of strain, vaccine and preparation method of vaccine

A technology of coxsackie virus and virus strain, applied in antiviral immunoglobulins, biochemical equipment and methods, antiviral agents, etc., can solve the difference in antigenicity and immunogenicity, the gap is large, and the pathogenic mechanism is unclear and other problems, to achieve the effect of effective immune activity and strong virulence
CN104099301AActive
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)

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Abstract

The invention provides a Coxsackie virus A16 virus strain, uses of the strain, a vaccine and a preparation method of the vaccine. The preservation number of the Coxsackie virus A16 virus strain is CGMCC No.6954. The CA16 virus strain has strong virulence, can be used for evaluating the CA16 vaccine, and can also be used for researching the CA16 virus infection mechanism. A method for establishing a Coxsackie virus A16 infected animal model provided by the invention can provide a stable animal model, and provides a foundation for the development of the Coxsackie virus A16 vaccine, the screening of antiviral drugs and the researches of the CA16 virus infection mechanism. The vaccine prepared by using the CA16 virus has effective immune activity.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, in particular, relates to a Coxsackie virus A16 strain and its use, a vaccine for preventing and / or treating hand, foot and mouth disease and its preparation method, antibody or hybridoma cell or anti- The serum and its preparation method, and the establishment method of an animal model infected by Coxsackie virus A16. Background technique

[0002] Hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus infection. Rash, herpes, and ulcers are typical manifestations, and a small number of patients may cause complications such as myocarditis, pulmonary edema, aseptic meningitis, and encephalitis. There are more than 20 enteroviruses (types) that cause HFMD, among which Coxsackievirus A16 (Coxsackievirus A16, CA16) and enterovirus 71 (Enterovirus71, EV71) are the most common. HFMD was first reported in New Zealand in 1957, and the Coxsackie virus was isolated in 1958. Th...

Claims

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