Metronidazole suppository and preparation method thereof

Abstract

The invention discloses a metronidazole suppository. Each metronidazole suppository contains 180-220mg of metronidazole, 150-180mg of clotrimazole and 6-10mg of chlorhexidine acetate, as well as 5-35mg of paraffin, 10-40mg of lanolin and 150-2000mg of semi-synthetic fatty acid glyceride as auxiliary materials. Due to adoption of the auxiliary materials, both the curative effect of the formula is maintained, and the stability of the three main medicines is ensured; furthermore, the release of the medicines is accelerated; the local stimulation tests, the acute toxicity tests and the long-term stability tests show that the metronidazole suppository is free of local or whole-body toxic reaction and is safe and effective to use. A specification of high dosage is especially designed, so that the metronidazole suppository disclosed by the invention can be applied to rapid and immediate sterilization, can shorten the treatment course and can prevent drug resistance.

Description

technical field [0001] The invention relates to a Shuangzotai suppository and a preparation method thereof. Background technique [0002] Years of clinical application have shown that Shuangzotai suppository has clear curative effect on the treatment of bacterial mixed infection, fungal and trichomonal vaginitis. However, the Shuangzotai suppository in the current Pharmacopoeia is a low-volume preparation, which cannot achieve rapid sterilization with a sudden dose, and the course of treatment is relatively long, which is prone to drug resistance. Moreover, because the plastid of Shuangzotai Suppository is relatively hard, and its cold-shrinking preparation process makes its appearance not very regular and smooth, it will often damage the vagina when it is inserted into the vagina; and the suppository becomes brittle in winter and brittle in summer. It is easy to melt and sticky to hands; it is inconvenient to use and cannot guarantee the accuracy of the dose sent into the ...

AI Technical Summary

Problems solved by technology

However, the Shuangzotai suppository in the current Pharmacopoeia is a low-volume preparation, which cannot achieve rapid sterilization with a sudden dose, and the course of treatment is relatively long, which is prone to drug resistance

Moreover, because the plastid of Shuangzotai Suppository is relatively hard, and its cold-shrinking preparation process makes its appearance not very regular and smooth, it will often damage the vagina when it is inserted into the vagina; and the suppository becomes brittle in winter and brittle in summer. Easy to melt and sticky; it is inconvenient to use and cannot guarantee the accuracy of the dose delivered into the body, which ultimately affects the stability of the curative effect

Some people in China have developed a water-soluble ointment of Shuangzoltai suppository, but its application is affected due to its poor stability.

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