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Skin pigmentation imaging device based on photoacoustic principle

A skin pigmentation, imaging device technology, applied in medical science, sensors, diagnostic recording/measurement, etc., to achieve the effect of reducing the contact area, convenient operation, and easy operation

Active Publication Date: 2014-11-19
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no device for imaging skin pigmentation in the prior art, therefore, it is necessary to invent a device for quickly imaging skin pigmentation

Method used

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  • Skin pigmentation imaging device based on photoacoustic principle
  • Skin pigmentation imaging device based on photoacoustic principle
  • Skin pigmentation imaging device based on photoacoustic principle

Examples

Experimental program
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Embodiment 1

[0040]A skin pigmentation imaging device based on the photoacoustic principle includes a computer imaging and control system, a photoacoustic signal excitation system, a photoacoustic signal acquisition system, an electric focusing integrated probe and a three-dimensional positioning device. The laser drive controls the pulse laser to output a pulsed laser with a wavelength of 1064nm, which enters the scanning mirror through the beam collimation filter system, and the outgoing beam is diverted by the scanning mirror to pass through the ultrasonic detector and the coupling cup, and the optical signal excites the tissue to be measured to generate a photoacoustic signal. The photoacoustic signal generated by the tissue to be measured is received by the electric focusing integrated probe, amplified by the pre-signal amplifier, collected by the high-speed data acquisition card and stored in the computer. The laser drive controls the opening and closing of the pulsed laser, and the p...

Embodiment 2

[0043] In this embodiment, the red ink is pre-coated on the lower surface of the cover glass and the upper surface of the slide glass, and one side of the cover glass is lifted to make a certain inclination between the slide glass and the upper and lower surfaces of the sample. The coupling liquid is filled between the sample surface and the light-transmitting sound-transmitting film on the lower surface of the coupling cup for acoustic coupling. In the experiment, the repetition frequency of the pulsed laser is 20kHz, the pulse width is 10ns, and the pulsed laser emits a pulsed laser with a wavelength of 1064nm, which is irradiated on the sample. The photoacoustic signal excited by the laser is received by the hollow ring ultrasonic detector, filtered and amplified by the preamplifier, collected by the high-speed data acquisition card and stored in the computer. Using the LabView acquisition control program to realize the real-time display of the image, you can quickly get su...

Embodiment 3

[0046] Figure 4 It is to use the device of the present invention to detect skin pigmentation imaging in vivo. Select the part with pigmentation on the volunteer's skin surface for measurement, observe the part of the skin to be measured through the CCD, and use the three-dimensional positioning device to place the detector close to the surface of the skin to be measured, and run the acquisition program. After the photoacoustic signal containing skin information is collected Stored in the computer, in the LabView acquisition control program, the real-time acquisition image is obtained, and the position of the light focus is adjusted through the electric focus ring to obtain the photoacoustic image of pigmentation, such as Figure four shown.

[0047] The device of the invention can clearly distinguish the stratum corneum and pigmentation of the skin, and realize the detection of pigmentation lesions of different depths by changing the position of the light focus. The detecti...

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Abstract

The invention relates to a skin pigmentation imaging device based on a photoacoustic principle, and belongs to the technical field of photoacoustic imaging. The skin pigmentation imaging device comprises a computer imaging and control system, a photoacoustic signal excitation system, a power-driven focusing integrated probe and a three-dimensional positioning device. The power-driven focusing integrated probe comprises an ultrasound detector, an objective lens and a tapered ultrasound coupling cup, wherein the ultrasound detector and the objective lens are connected through a power-driven focusing ring. The three-dimensional positioning device adjusts the space position of the power-driven focusing integrated probe to achieve positioning of tissue to be detected through a coupling cup. The computer imaging and control system controls operation of the three-dimensional positioning device, controls opening and closing of the photoacoustic signal excitation system, receives and processes data and achieves high-resolution real-time imaging of pigmentation lesions at different depths by adjusting the power-driven focusing ring and the depth of optical focusing points. The skin pigmentation imaging device has the advantages of being free of pains and capable of quick and real-time imaging.

Description

technical field [0001] The invention relates to the technical field of photoacoustic imaging, in particular to a skin pigmentation imaging device based on the photoacoustic principle. Background technique [0002] Skin hyperpigmentation is the pigmentation change of human skin in different colors, ranges and depths due to various reasons. Skin pigmentation can be divided into chloasma, pregnancy spot, butterfly spot, age spot, coffee spot and freckle according to the type. It is a common multiple skin disease. Different types have different depths of pigmentation. There is no device for imaging skin pigmentation in the prior art. Therefore, it is necessary to invent a device for quickly imaging skin pigmentation. [0003] Photoacoustic imaging is a non-invasive and non-destructive imaging method. It is based on the photoacoustic effect and uses short-pulse laser light on the order of nanoseconds to irradiate biological tissue. After the short-pulse laser is absorbed by the ...

Claims

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Application Information

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IPC IPC(8): A61B5/00
Inventor 邢达王雅婷许栋杨思华
Owner SOUTH CHINA NORMAL UNIVERSITY
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