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Method for preparing natural vitamin E and phytosterols by resin adsorption method

A technology of natural vitamins and phytosterols, which is applied in the field of preparation of natural vitamin E and phytosterols by resin adsorption method, can solve the problems of unfavorable industrial production, harsh production conditions, loss of vitamin E, etc., and achieve easy control of crystallization conditions, low production cost, The effect of high product yield

Active Publication Date: 2017-01-18
山东圣地嘉禾生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Either the reaction conditions are harsh and easy to cause the loss of vitamin E, or the production conditions are harsh or the process control is complicated, which is not conducive to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The resin adsorption method prepares the method for natural vitamin E and phytosterol, comprises the following steps:

[0045] (1) Fatty acid removal: 1# resin column is loaded with 500ml strong basic anion resin, prepares 1500ml1mol / L hydrochloric acid solution to wash resin with 500ml / h flow rate, then rinses resin with deionized water until the pH value of the effluent is 4; prepare 1500ml1mol / L sodium hydroxide solution to wash the resin at a flow rate of 500ml / h, then rinse the resin with deionized water until the pH value of the effluent is 7; prepare 1500ml1mol / L hydrochloric acid solution to wash the resin at a flow rate of 500ml / h, and then rinse the resin with deionized water until it flows out The liquid pH value is 4; Replace the deionized water in the resin column with 95% ethanol solution until the ethanol concentration of the effluent is 92%, stop the replacement, and 1600ml soybean oil deodorized distillate enters the resin column with a flow rate of 400...

Embodiment 2

[0053] The resin adsorption method prepares the method for natural vitamin E and phytosterol, comprises the following steps:

[0054] (1) Defatty acid removal: 1# resin column is loaded with 500ml strong basic anion resin, and 1500ml1mol / L hydrochloric acid solution is prepared to wash the resin at a flow rate of 500ml / h, then rinse the resin with deionized water until the pH value of the effluent is 5; prepare 1500ml1mol / L Wash the resin with L sodium hydroxide solution at a flow rate of 500ml / h, then rinse the resin with deionized water until the pH value of the effluent is 7; prepare 1500ml1mol / L hydrochloric acid solution to wash the resin at a flow rate of 500ml / h, then rinse the resin with deionized water to the effluent The pH value is 5; the deionized water in the resin column is replaced with 95% ethanol solution to 92% ethanol concentration in the effluent, and the replacement is stopped, and the 3000ml vegetable oil deodorization distillate mixture (wherein 2500ml co...

Embodiment 3

[0062] The resin adsorption method prepares the method for natural vitamin E and phytosterol, comprises the following steps:

[0063] (1) Defatty acid removal: 1# resin column is loaded with 500ml strong basic anion resin, and 1500ml1mol / L hydrochloric acid solution is prepared to wash the resin at a flow rate of 500ml / h, then rinse the resin with deionized water until the pH value of the effluent is 4; prepare 1500ml1mol / L Wash the resin with L sodium hydroxide solution at a flow rate of 500ml / h, then rinse the resin with deionized water until the pH value of the effluent is 8; prepare 1500ml1mol / L hydrochloric acid solution to wash the resin at a flow rate of 500ml / h, then rinse the resin with deionized water to the effluent The pH value is 5; replace the deionized water in the resin column with 95% ethanol solution until the ethanol concentration of the effluent is 92%, stop the replacement; enter the 1000ml olive oil deodorized distillate into the resin column at a flow rat...

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Abstract

The invention discloses a resin absorption method used for preparing natural vitamin E and phytosterol, and relates to the technical field of separation extraction in bio-engineering. The method comprises the following steps: fatty acid is removed; washing is carried out; cold precipitation and filtering are carried out; drying is carried out, such that phytosterol is obtained; absorption is carried out, desorption is carried out; and distillation concentration is carried out, such that vitamin E is obtained. According to the resin absorption method for preparing natural vitamin E and phytosterol, with a fatty acid characteristic of easy ionization, strongly alkaline anion exchange resin is selected and is subjected to a transformation treatment; and the resin is used for carrying out specific absorption upon fatty acid in deodorized distillate, such that fatty acid can be removed, and vitamin E loss during a fatty acid esterification process is avoided. The reaction conditions are mild, and product yield is high. Operation is convenient, and production efficiency is improved. The obtained phytosterol has good crystal form. Crystallization conditions are easy to control, and product quality is high. During the production process, less equipment is used, and the resin can be repeatedly used. Production cost is low, and batch production is easy.

Description

technical field [0001] The invention belongs to the technical field of separation and extraction in bioengineering, and in particular relates to a method for preparing natural vitamin E and phytosterols by a resin adsorption method. Background technique [0002] Natural vitamin E, also known as natural tocopherol, is one of the earliest vitamins discovered by humans. Tocopherol was discovered by Evans et al. from wheat germ extract in 1922. Tocopherol is a substance that can affect the reproductive ability of animals, so it was named "anti-sterility vitamin". In 1938, American E. Fernholz described the molecular formula of biologically active natural tocopherol in his paper. In the same year, P.vonKarrer and H.Fritzsche and others successfully synthesized biologically active tocopherol composed of different diastereoisomers for the first time. In the 1980s, natural tocopherol became popular all over the world, and many countries such as the United States, Germany, and Japa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/72C07J9/00C07J75/00
CPCC07D311/72C07J9/00
Inventor 朱雷常晓菲左良成张伟李若坤
Owner 山东圣地嘉禾生物工程有限公司