Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy

A quality detection method and diabetic retinal technology, applied in the fields of pharmacy and analytical chemistry, can solve problems such as difficulty in fully reflecting the quality of traditional Chinese medicine compositions, complicated Chinese medicine ingredients, single qualitative identification or content determination, etc.

Active Publication Date: 2014-11-26
BEIJING HANDIAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because the prescription has many medicinal flavors and complex Chinese medicinal ingredients, it is difficult to fully reflect the quality of the traditional Chinese medicinal composition by a single qualitative identification or content determination.

Method used

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  • Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy
  • Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy
  • Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0179] Example 1 A quality detection method for traditional Chinese medicine tablets for treating diabetic retinopathy

[0180] 1. The dosage of raw materials

[0181] Astragalus 3000g, Ligustrum lucidum 900g, Motherwort 900g, Black plum 300g, Coptis 200g, Cinnamon 200g, Budisma 300g.

[0182] 2. Preparation method

[0183] (1) Prepare various medicinal materials according to the prescription.

[0184] (2) Take cinnamon, add water 10 times the weight of the medicinal material, extract the volatile oil by steam distillation, collect the distilled aqueous solution in another device, and use the dregs for subsequent use; add 2 times the volume of absolute ethanol to dissolve the volatile oil; take 10 times the weight of the volatile oil volume of β-cyclodextrin, add water 25 times the weight of β-cyclodextrin to make β-cyclodextrin aqueous solution; at a speed of 150 rpm, slowly add volatile oil ethanol to the β-cyclodextrin aqueous solution After the addition of the solutio...

Embodiment 2

[0220] Example 2 A quality detection method of traditional Chinese medicine concentrated pills for treating diabetic retinopathy

[0221] 1. The dosage of raw materials

[0222] Astragalus 4500g, Ligustrum lucidum 1200g, Motherwort 1200g, Black plum 600g, Coptis 600g, Cinnamon 350g, Budisma 600g.

[0223] 2. Preparation method

[0224] (1) Prepare various medicinal materials according to the prescription.

[0225] (2) the above medicinal materials, the volume percentage concentration of 10 times of the weight of the medicinal materials is 50% ethanol heating and reflux extraction for 2 times, each time for 1.5 hours, filtering, merging the ethanol extracts twice, reclaiming ethanol, and concentrating under reduced pressure to Measure the extract whose relative density is 1.20-1.30 at 80°C, extract the extract 1, and prepare the dregs for later use;

[0226] (3) Step (2) Chinese medicine dregs is extracted twice by heating and refluxing with water 8 times the weight of the...

Embodiment 3

[0259] Example 3 A quality detection method of traditional Chinese medicine granules for treating diabetic retinopathy

[0260] 1. The dosage of raw materials

[0261] Astragalus 6000g, Ligustrum lucidum 1500g, Motherwort 3000g, Ume 1000g, Coptis 900g, Cinnamon 500g, Budisma 900g.

[0262] 2. Preparation method

[0263] (1) Prepare various medicinal materials according to the prescription.

[0264] (2) Take cinnamon, add 12 times the amount of water, extract the volatile oil with steam distillation, collect the distilled aqueous solution in another device, and use the dregs for later use; add 3 times the amount of absolute ethanol to dissolve the volatile oil, and use 20 times the amount of β-ring A solution prepared by adding 40 times the amount of water to dextrin is used for clathrate to obtain clathrate of volatile oil.

[0265] (3) Radix Astragali, Ligustrum lucidum, Budhimonica japonica plus 100% ethanol with 14 times the weight of medicinal materials were reflux e...

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Abstract

The invention provides a quality detection method of a traditional Chinese medicinal composition for curing diabetic retinopathy. Raw medicines of the traditional Chinese medicinal composition comprise, by weight, 30-60 parts of Radix Astragali, 9-15 parts of ligustrum lucidum, 9-30 parts of motherwort, 3-10 parts of dark plum, 2-9 parts of coptis, 1-5 parts of cortex cinnamomi and 3-9 parts of Buddleja officinalis. The quality detection method comprises steps as follows: content determination of astragaloside, berberine and linarin in the traditional Chinese medicinal composition and thin-layer chromatography of the above seven raw medicines. The quality detection method provided by the invention has advantages of high specificity, simple, accurate and reliable operation and good reappearance. By the quality detection method, clinical medication safety can better be guaranteed.

Description

technical field [0001] The invention belongs to the field of pharmacy and analytical chemistry, and in particular relates to a quality detection method of a traditional Chinese medicine composition for treating diabetic retinopathy. Background technique [0002] Diabetic Retinopathy (DR) is one of the serious and common eye complications of diabetes. With the prolongation of the duration of diabetes, the incidence of DR also increased. The incidence of diabetic retinopathy is about 50% in those with a course of more than 8 years. The early symptoms of the disease are not obvious and are easy to be ignored. In the late stage, there is no effective control method, and the disease is lingering and intractable. If the disease is not treated, the consequences are serious, and it is the main cause of adult blindness, with a blinding rate of 8-12%, which has a serious adverse effect on the quality of life of the affected population. Therefore, the prevention and treatment of DR ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P3/10A61P9/10G01N30/90G01N30/36
Inventor 林德良
Owner BEIJING HANDIAN PHARMA CO LTD
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