A kind of medicine for preventing and treating restenosis and its preparation and use method

A restenosis and drug technology, applied in drug combinations, cardiovascular system diseases, etc., can solve the problems of increasing medical costs and patients' economic burden, increasing the incidence of death or myocardial infarction, serious drug toxicity and side effects, etc., to achieve The chemical structure is clear, the effect of avoiding long-term thrombotic complications and avoiding adverse effects
CN104188957BActive Publication Date: 2017-04-26XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
Publication Date
2017-04-26

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Abstract

The invention discloses a medicine for preventing and curing restenosis and a preparation method and a using method thereof. The effective components of the medicine include guaianese squiterpenes compounds P1, P2 and P3, wherein P1 is Zedoalactone B; P2 is a stereoisomer of P1; P3 is Zedoarondiol; and the effective components are extracted from Curcum lump powder by water bath, ultrafiltration separation, nanofiltration concentration, chromatographic purity analysis and nuclear magnetic resonance structure comparison. The using method of the medicine is to coat a carrying device with the medicine taking the compounds P1, P2 and P3 as the effective components. The medicine can prevent and cure restenosis, and compared with a conventional sirolimus-eluting stent, the medicine can inhibit the proliferation of vascular smooth muscle cells and inflammatory responses of vascular walls. Besides, the medicine can promote healing of vascular endothelial cells, avoids long-term thrombotic complications; and the dose is low, the cost is low and toxic or side effects are avoided.
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Description

technical field

[0001] The invention relates to the field of extracts of traditional Chinese medicines, in particular to a medicine for preventing and treating restenosis with guaiac-type sesquiterpene compounds as active ingredients, a method for preparing the medicine with zedoary and a method for using the medicine. Background technique

[0002] At present, percutaneous coronary intervention (PCI) is the main method for the treatment of coronary heart disease, but the main defect of this method is postoperative restenosis at the site of stenting. Intravascular thrombosis, elastic recoil, arterial remodeling, neointimal hyperplasia, smooth muscle hyperplasia, vascular remodeling and inflammation are the main factors leading to restenosis.

[0003] In order to solve the problem of restenosis, in recent years, traditional stents are commonly coated with drugs to inhibit the occurrence of restenosis. Significant progress has been made in restenosis, but because these drugs c...

Claims

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