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Bilayered tablet comprising repaglinide and meformin and preparation method thereof

A technology of metformin and double-layer tablets is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, pills, etc.

Inactive Publication Date: 2014-12-17
DALIM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] According to the above research results, in U.S. Patent No. 6,677,358, although a pharmaceutical composition comprising metformin and repaglinide is disclosed, this document only discloses the pharmacological effects obtained by using the above two drugs in combination, without disclosing specific dosage forms

Method used

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  • Bilayered tablet comprising repaglinide and meformin and preparation method thereof
  • Bilayered tablet comprising repaglinide and meformin and preparation method thereof
  • Bilayered tablet comprising repaglinide and meformin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Preparation of Granules Containing Repaglinide

[0060] In order to prepare granules containing repaglinide, a combination solution in which povidone K30 and poloxamer 407 were dissolved in water was prepared with the composition shown in Table 1 below. Dissolve repaglinide, meglumine, and concentrated glycerin in the combination solution. Separately mix anhydrous calcium hydrogen phosphate, microcrystalline cellulose, pregelatinized starch, and red iron oxide, stir and dry it with a mixture dissolved in repaglinide, sieve with a mesh sieve to prepare wet granules, and put Add croscarmellose sodium and magnesium stearate and mix to prepare repaglinide granules.

[0061] Preparation of granules comprising metformin hydrochloride

[0062] With the composition shown in the following Table 1, metformin hydrochloride was stirred and dried with a combined solution of povidone K30 dissolved in ethanol and water, sieved with a mesh sieve to prepare wet granules, and stearic a...

Embodiment 2

[0067] Preparation of Granules Containing Repaglinide

[0068] In order to prepare granules containing repaglinide, a combination solution in which povidone K30 and poloxamer 407 were dissolved in water was prepared with the composition shown in Table 2 below. Dissolve repaglinide and meglumine in the combination solution. Separately mix anhydrous calcium hydrogen phosphate, microcrystalline cellulose, pregelatinized starch, and red iron oxide, stir and dry it with a mixture dissolved in repaglinide, sieve with a mesh sieve to prepare wet granules, and put Add croscarmellose sodium and magnesium stearate and mix to prepare repaglinide granules.

[0069] Preparation of granules comprising metformin hydrochloride

[0070] With the composition shown in Table 2 below, metformin hydrochloride was stirred and dried with a combination solution of povidone K30 and concentrated glycerin dissolved in ethanol and water, and was sieved with a mesh sieve to prepare wet granules. magnesi...

Embodiment 3

[0075] Preparation of Granules Containing Repaglinide

[0076] In order to prepare granules containing repaglinide, a combination solution in which povidone K30 and poloxamer 407 were dissolved in water was prepared with the composition shown in Table 3 below. Dissolve repaglinide, meglumine, and concentrated glycerin in the combination solution. Separately mix anhydrous calcium hydrogen phosphate, microcrystalline cellulose, pregelatinized starch, and red iron oxide, stir and dry it with a mixture dissolved in repaglinide, sieve with a mesh sieve to prepare wet granules, and put Add croscarmellose sodium and magnesium stearate and mix to prepare repaglinide granules.

[0077] Preparation of granules comprising metformin hydrochloride

[0078] With the composition shown in the following Table 3, metformin hydrochloride was stirred and dried with a combined solution of povidone K30 and concentrated glycerin dissolved in ethanol and water, and was sieved with a mesh sieve to p...

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Abstract

The invention provides a bilayered tablet comprising repaglinide and meformin and a preparation method thereof. The bilayered tablet is characterized by comprising a first layer containing the repaglinide or other medical salt and a second layer containing the meformin or other medical salt.

Description

technical field [0001] The present invention relates to a double-layer tablet containing repaglinide and metformin, more specifically, the present invention relates to a hypoglycemic compound preparation, which is a double-layer tablet containing repaglinide and metformin. More specifically, the present invention relates to a double-layer tablet, which is a pharmaceutical composition containing repaglinide and metformin. The release of the two drugs does not interfere with each other. Dissolution profiles similar to single formulations of each drug were obtained. In addition, the present invention relates to a bilayer tablet, which is characterized in that it is a bilayer tablet containing repaglinide and metformin, and contains concentrated glycerin to prevent interlayer separation caused by external factors such as preparation, storage, and distribution. Background technique [0002] In the treatment of diabetes, sulfonylureas are often used as oral hypoglycemic agents. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/451A61K47/10A61P3/10A61K31/155
CPCA61K9/2013A61K9/209A61K9/2095A61K31/155A61K31/4453A61K2300/00
Inventor 金相基崔正铉朴赞艾申桓守
Owner DALIM BIOTECH
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