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Method for extracting polysaccharide ingredient from astragalus membranaceus and glossy privet fruit composition by alkaline extraction and alcohol deposition method and product produced by method

A technology of polysaccharides and alcohol precipitation method, which is applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve the problems of large dosage of patients, unsatisfactory production and use, and low extraction rate of polysaccharides

Inactive Publication Date: 2014-12-24
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction of polysaccharides in Zhenqi Fuzheng drugs mostly adopts the method of water extraction and alcohol precipitation. The disadvantage of this type of method is that the extraction rate of polysaccharides is low, and the extraction cost is high, which cannot meet the needs of production and use. Larger, but also directly affect the quality and clinical efficacy of the product

Method used

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  • Method for extracting polysaccharide ingredient from astragalus membranaceus and glossy privet fruit composition by alkaline extraction and alcohol deposition method and product produced by method
  • Method for extracting polysaccharide ingredient from astragalus membranaceus and glossy privet fruit composition by alkaline extraction and alcohol deposition method and product produced by method
  • Method for extracting polysaccharide ingredient from astragalus membranaceus and glossy privet fruit composition by alkaline extraction and alcohol deposition method and product produced by method

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Experimental program
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Effect test

Embodiment 1

[0065] Embodiment 1 of the present invention: a method for extracting the polysaccharide components in the composition of chastity qi by alkali extraction and alcohol precipitation method is: according to the weight ratio of 2:1, astragalus and Ligustrum lucidum are weighed, and Astragalus and Ligustrum lucidum are individually or After mixing, add 6 times the amount of potassium carbonate solution with a pH value of 8, decoct at 90°C for 1 hour, filter while hot, decoct the filter residue twice in the same way, and combine the filtrate; concentrate the filtrate, add 95% Ethanol until the alcohol content reaches 70%, let it stand overnight, centrifuge, dry the precipitate, add water to dissolve it, put it on a hollow fiber column, and cut off the components with a molecular weight above 3kDa, collect the resulting retentate, concentrate to dryness, dialyze after reconstitution, and dry, That is, the polysaccharide component extract.

Embodiment 2

[0066] Example 2 of the present invention: a method for extracting the polysaccharide components in the chastity stilbee composition by alkali extraction and alcohol precipitation method is as follows: weigh Astragalus membranaceus and Ligustrum lucidum according to a weight ratio of 2:1, and separately or After mixing, add 10 times the amount of sodium hydroxide solution with a pH value of 9, and add ethanol to the sodium hydroxide solution to make the final concentration of ethanol 5%, decoct at 95°C for 1.5 hours, filter while hot, and use the filter residue Decoct twice in the same way, combine the filtrate; concentrate the filtrate, add 95% ethanol to the concentrated filtrate until the alcohol content reaches 80%, let it stand overnight, centrifuge, dry the precipitate, add water to dissolve it, and put it on a hollow fiber column with a molecular weight cut-off of 3kDa For the above components, the retentate obtained is collected, concentrated to dryness, reconstituted, ...

Embodiment 3

[0067] Example 3 of the present invention: a method for extracting the polysaccharide components in the composition of chastity qi by an alkali extraction and alcohol precipitation method is as follows: take astragalus and Ligustrum lucidum according to a weight ratio of 2:1, and astragalus and Ligustrum lucidum separately or After mixing, add 15 times the amount of potassium hydroxide solution with a pH value of 12, reflux and extract at 100°C for 3 hours, filter while hot, and use the same method to reflux and extract the filter residue twice, and combine the filtrate; the filtrate is concentrated, and 95 % ethanol until the alcohol content reaches 90%, let it stand overnight, centrifuge, dry the precipitate, add water to dissolve it, put it on a hollow fiber column, and cut off the components with a molecular weight above 3kDa, collect the resulting retentate, concentrate to dryness, and ultrafilter after reconstitution. Dried, that is, the polysaccharide component extract. ...

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Abstract

The invention discloses a method for extracting a polysaccharide ingredient from an astragalus membranaceus and glossy privet fruit composition by an alkaline extraction and alcohol deposition method, and a product produced by the method. The method comprises the following steps: weighing astragalus membranaceus and glossy privet fruit according to the weight ratio of 2 to 1, independently adding or adding the astragalus membranaceus and the glossy privet fruit to 6-15fold alkaline solution of which the pH value is 8-12 in a mixing manner; heating and extracting at 90-100 DEG C for 1-3 hours, filtering when the solution is hot, extracting filter residues twice by using the same method, and mixing filtrates; concentrating the filtrate, adding 95% ethanol to the concentrated filtrate until the alcohol content reaches 70%-90%; standing over the night, centrifuging, and drying sediments, so as to obtain a polysaccharide ingredient extract; and applying the polysaccharide ingredient extract which is obtained by using the extraction method to centralizing drugs of astragalus membranaceus and glossy privet fruit. According to the method, the extraction rate of the polysaccharide effective ingredient in the astragalus membranaceus and glossy privet fruit composition can be increased, and the extraction cost is reduced, so that the dose of a centralizing preparation of the astragalus membranaceus and the glossy privet fruit is reduced, and the treatment effect is relatively good.

Description

technical field [0001] The invention relates to a method for extracting polysaccharide components in a Zhenqi composition by an alkali extraction and alcohol precipitation method and a product thereof, belonging to the technical field of preparation of Zhenqi Fuzheng preparations. Background technique [0002] Zhenqi Fuzheng preparation has the effects of invigorating qi and nourishing yin, strengthening the body and strengthening the body. Modern pharmacological experiments have proved that it can improve the immune function of the human body, protect the function of bone marrow and adrenal cortex, and promote the production of interferon; cooperate with radiotherapy and chemotherapy of tumor patients, reduce the toxic and side effects of patients during radiotherapy and chemotherapy, and promote the recovery of normal functions. Its prescription consists of Astragalus and Ligustrum lucidum. At present, the dosage forms of Zhenqi Fuzheng preparation for clinical selection ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P37/04A61P35/00
Inventor 张观福
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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