Tissue repair support and its preparation method and use
A tissue repair and composite fiber technology, which is applied in the field of biomedical devices and their preparation, can solve the problems of insufficient connection of different interface layers, weak binding force, complicated processes, etc., and achieves easy control of product quality, short production time, and simple process. Effect
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[0047] The preparation method of the tissue repair scaffold is characterized in that, the adhesion factor and the hydrophobic synthetic material are dissolved in the same solvent, and then through electrospinning technology, centrifugal spinning technology, hot-melt spinning technology, melting electrospinning technology One or more combinations of spinning techniques are used to obtain the surface containing the composite fiber. Among them, electrospinning technology, centrifugal spinning technology, hot melt spinning technology, and melt electrospinning technology are preferably used, and centrifugal spinning technology and electrostatic spinning technology are more preferably used.
[0048] The composite fiber used in the tissue repair scaffold of the present invention can be prepared by centrifugal spinning technology. The hydrophobic synthetic material and adhesion factor can be dissolved in the same solvent at the same time to form a uniform solution. The solution enters...
Embodiment 1
[0055] Dissolve PCL and gelatin in trifluoroethanol according to the mass ratio of 10:1 to form a solution, and then the solution enters the centrifugal spinning machine through the propulsion pump, the propulsion pump propulsion speed is 150g / min, the centrifugal disc line speed is 6000m / min, the solution Fibers are spun rapidly, and the spinning temperature is 50°C. After the spinning is finished, the film is taken off from the receiving roll, and the solvent is removed by vacuum drying to obtain the composite fiber material of the scaffold.
[0056] The SEM image of the composite fiber is shown in figure 1 -A, after the composite fiber is treated in 50°C water that can dissolve gelatin but not PCL, its SEM image is shown in figure 1 -B, it can be clearly seen that the composite fiber has a composite structure of PCL and gelatin.
Embodiment 2
[0058] PLLA and chitosan are dissolved in trifluoroacetic acid according to the mass ratio of 10:9 to form a solution, and then the solution enters the centrifugal spinning machine through the propulsion pump, the propulsion speed of the propulsion pump is 100g / min, and the linear velocity of the centrifugal disc is 3000m / min , the solution is rapidly spun into fibers, and the spinning temperature is 80°C. After the spinning is completed, the film is removed from the receiving roll, and the solvent is removed by vacuum drying to obtain the composite fiber material of the scaffold.
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