Multicomponent oral care composition

A technology for oral health care and composition, which can be used in medical preparations containing active ingredients, oral care, drug combinations, etc., and can solve problems such as increasing solubility

Inactive Publication Date: 2014-12-31
PERIO PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fluoride is incorporated within the hydroxyapatite crystals, resulting in larger and less soluble crystals

Method used

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  • Multicomponent oral care composition
  • Multicomponent oral care composition
  • Multicomponent oral care composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0028] According to one embodiment, the composition includes a suitable buffer system. Exemplary buffer systems contemplated by the present invention include, but are not limited to, those comprising one or more acetates, carbonates, citrates or phosphates.

[0029] The oral care composition can be included, for example, in a toothpaste, mouth spray or mouthwash / rinse formulation, or other formulation that can be used to improve oral hygiene. Such formulations will of course be readily apparent to those skilled in the art.

[0030] The oral care compositions of the present invention are more effective at achieving remineralization of primary carious lesions than when the components herein are used alone or separately. The fluoride source provides fluoride ions for the formation of fluorapatite, while hydroxyapatite provides calcium and phosphate ions, as well as chlorine dioxide to kill plaque-forming bacteria. Use this composition to significantly eliminate plaque and promote...

Embodiment 1

[0081] According to the preparation method of typical toothpaste preparation of the present invention can carry out according to following steps:

[0082] Purified water BP was added to the vessel and stirring was started. Sodium saccharin, trisodium phosphate and sodium monofluorophosphate were added and allowed to dissolve. The glycerin and cellulose gum were thoroughly premixed and added to the main vessel using high shear mixing. Hydrated silica, hydroxyapatite and peptide dioxide were added and mixed under high shear until a smooth homogeneous paste was produced. The container has a hood which is cooled by chilled water to ensure that the temperature of the contents is maintained below 40°C.

[0083] Menthol, Peppermint Oil BP and Spearmint Oil BP were premixed in separate containers to create a flavor blend. The above mixture is then added to the paste in the main container while mixing.

[0084] Add 5% chlorine dioxide solution (proprietary blend) to the paste while...

Embodiment 2

[0087] The preparation method of a typical oral rinse or mouthwash formulation according to the present invention can be carried out according to the following steps:

[0088] Purified water BP / EP was added to the vessel and heated to 80°C (±5°C). The water is then agitated and recirculated through an in-line high shear homogenizer.

[0089] Kelcogel HA (high acyl content gellan gum - a polysaccharide composed of repeating units of glucose, rhamnose, and glucuronic acid, with a substituted glycerate moiety on each glucose unit and Acetate moieties on each second glucose moiety), and Cekol 4000 (carboxymethylcellulose polymer to minimize flocculation and aid bioadhesion) for impregnation. Glycerin comprising the premix was then added to the hot water. The resulting mixture was stirred and homogenized for 15 minutes before cooling.

[0090] When the temperature of the water reaches + The addition of ions to the mixture causes the high acyl content gellan to thicken and form a...

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Abstract

The present invention relates to a multicomponent oral health care composition, comprising a source of a fluoride ion, a source of a calcium ion, a source of a phosphate ion, and stabilised chlorine dioxide, that can be used as a toothpaste, oral spray or a mouth wash/oral rinse formulation. The different components in the composition act synergistically together to clean the teeth and mucous membranes of an oral cavity of a subject, perfuming them or protecting them in order to keep them in good condition, change their appearance or correct unpleasant odours. They achieve this by inhibiting caries, promoting teeth remineralisation, and helping to alleviate dentine hypersensitivity, gingivitis and periodontal disease.

Description

technical field [0001] The present invention relates to multi-ingredient oral health care compositions which may be used as toothpaste, mouth spray, mouthwash or mouth rinse formulations. The different ingredients in the composition work together synergistically to clean the teeth and mucous membranes of the subject's mouth, scent them or protect them to keep them in good condition, change their appearance or correct unpleasant odors. They do this by inhibiting caries, promoting tooth remineralization, and helping to alleviate dentine hypersensitivity, gingivitis, and periodontal disease. Background technique [0002] Human and animal tooth minerals are based on calcium apatite, Ca 5 (PO 4 ) 3 Oh. Natural dental apatite is a heavy solid substituted, and in the lattice Ca 2+ can be for example, Sr 2+ , Mg 2+ or Zn 2+ , or two Na + Cationic substitution. Phosphate anion (PO 4 ) 3- can be absorbed by carbonate ions (CO 3 2- ) replaced, while the associated Na + C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K33/16A61K33/06A61K33/20A61Q11/00A61K8/24A61K8/19A61K8/20A61K8/21
CPCA61Q11/00A61K8/20A61K8/21A61K33/06A61K33/20A61K33/42A61K8/24A61K33/16A61P43/00A61K8/19A61K2300/00A61K2800/5922A61K2800/92A61K8/22A61K8/73
Inventor 罗伯特·希尔艾伦·J·科林斯伊恩·拜内斯戴维·G·吉勒姆
Owner PERIO PRODS
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