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Contact lens care preparation and packaging solution

A contact lens and packaging solution technology, applied in glasses/goggles, glasses/protective glasses, packaging, etc., can solve the problems of not inspecting the lubricity of the lens surface and insufficient effect, and achieve the purpose of inhibiting amoeba adhesion and durability The effect of surface lubricity

Active Publication Date: 2015-01-07
NOF CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of the copolymer on imparting lubricity to the lens surface or inhibiting the attachment of amoebas was not examined, and in fact, these effects were insufficient

Method used

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  • Contact lens care preparation and packaging solution
  • Contact lens care preparation and packaging solution
  • Contact lens care preparation and packaging solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0071] The present invention will be described in more detail below based on the examples, but these are not intended to limit the present invention.

[0072] In addition, various measurements in the examples were performed as follows.

[0073]

[0074] 5 mg of the obtained polymer was dissolved in 1 g of methanol / chloroform mixed solvent (8 / 2, volume ratio) to prepare a sample solution. Other conditions are described below.

[0075] Column: PLgel-mixed-C, standard substance: polyethylene glycol, detection: parallax refractometer RI-8020 (manufactured by Tosoh Corporation), calculation of weight average molecular weight (Mw): molecular weight calculation program (SC-8020 with GPC program), flow rate 1ml / min, sample solution injection volume: 100μl, column temperature 40°C.

[0076] The number average molecular weight of a polymer is the value of the number average molecular weight measured by gel permeation chromatography (GPC) using polyethylene glycol as a standard sampl...

Synthetic example 1-1

[0109] Synthesis Example 1-1 (Polymer A-1; MPC0.50-SMA0.05-DMAA0.45)

[0110] 31.75g ​​of MPC (manufactured by NOF Corporation), 3.64g of stearate methacrylate (SMA, manufactured by NOF Corporation) and 9.60g of N,N-dimethylacrylamide (DMAA, Xingren company) was dissolved in 55.0 g of ethanol, put into a four-necked flask, and blown with nitrogen for 30 minutes. Then, 0.10 g of a product name "PERBUTYL ND" (manufactured by NOF Corporation) (hereinafter abbreviated as PB-ND) was added at 50° C., and a polymerization reaction was performed for 8 hours. The polymerization solution was dripped into 3 liters of diethyl ether while stirring, and the precipitated precipitate was filtered and vacuum-dried at room temperature for 48 hours to obtain 40.2 g of powder. The molecular weight evaluated by GPC was a weight average molecular weight of 1,000,000. Let this be polymer A-1. The data of IR, NMR, and elemental analysis are shown below.

[0111] IR data: 2964cm -1 (-CH), 1733cm ...

Synthetic example 1-2

[0117] Synthesis Example 1-2 (Polymer A-2; MPC0.30-SMA0.03-DMAA0.67)

[0118] 24.13 g of MPC, 2.77 g of SMA and 18.11 g of DMAA were dissolved in 55.0 g of n-propanol, put into a four-neck flask, and blown with nitrogen for 30 minutes. Then, 0.10 g of PB-ND was added at 50° C., and a polymerization reaction was performed for 8 hours. The polymerization solution was dripped into 3 liters of diethyl ether while stirring, and the precipitated precipitate was filtered and vacuum-dried at room temperature for 48 hours to obtain 42.4 g of powder. The molecular weight evaluated by GPC was a weight average molecular weight of 1,200,000. Let this be polymer A-2. The data of IR, NMR, and elemental analysis are shown below.

[0119] IR data: 2964cm -1 (-CH), 1733cm -1 (O-C=O), 1651cm -1 (N-C=O), 1458cm -1 (-CH), 1253cm -1 (P=O), 1168cm -1 (C-O-C), 997cm -1 (P-O-C).

[0120] NMR data: 0.8-1.2ppm (CH3 -C-), 1.4ppm (-CH 2 -),3.3ppm(-N(CH 3 ) 3 ), 2.8-3.2ppm (-N-(CH 3 ) 2 ), ...

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PUM

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Abstract

Provided are a contact lens care preparation capable of imparting durable surface lubricity and amebic adhesion inhibitory effect to a contact lens surface through a simple treatment, and a contact lens packaging solution utilizing the same. The contact lens care preparation is composed of a solution containing 0.01 to 2 weight / volume% of a polymer having particular monomer units with a phosphorylcholine-like group, particular (meth) acrylamide derivative units, and particular monomer units with a hydrophobic group at a particular ratio, and a weight average molecular weight of 5,000 to 2,000,000, and is useful as a contact lens packaging solution.

Description

technical field [0001] The present invention relates to a contact lens care preparation capable of imparting durable surface lubrication to the surface of a contact lens by simple treatment, and a packaging solution used when sealing a contact lens in a container Sex and the effect of inhibiting the attachment of amoeba. Background technique [0002] In recent years, for the purpose of improving the wearing feeling of soft contact lenses, attempts have been made to include polymer substances that improve surface lubricity in care formulations or packaging solutions for the soft contact lenses. However, the conventionally proposed improvement using a polymer material is insufficient in durability, and the wearing feeling deteriorates especially when worn all day, so improvement is being sought. [0003] Commercially available lens care preparations used for storage of soft contact lenses generally have a disinfecting ability in order to prevent the proliferation of bacteria ...

Claims

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Application Information

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IPC IPC(8): G02C13/00
CPCC11D3/0078C11D3/3784C08F230/02C08F220/1818C08F220/54A61L12/00A61L12/08B65B25/00B65B25/008C08F20/10C08F26/00C08F30/00C08F30/02C11D7/00C11D7/02G02C13/00
Inventor 松冈阳介岩切规郎丸桥真央坂元伸行
Owner NOF CORP
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