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Curcumin nanor compound and preparation method thereof

A nanocomposite and curcumin technology, applied in food preparation, food science, food ingredients containing natural extracts, etc., can solve problems such as difficult to penetrate cells, large molecular weight, etc.

Active Publication Date: 2015-01-14
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of protein-based materials is that the molecular weight is large and it is difficult to penetrate cells
At present, there are no relevant reports on the application of chitosan and gum arabic compound in the embedding of functional components at home and abroad.

Method used

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  • Curcumin nanor compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Accurately weigh 0.18g chitosan and dissolve it in 90mL of acetic acid with a concentration of 1% (v / v), stir until completely dissolved, prepare a 0.2% chitosan homogeneous solution, filter and set aside. Accurately weigh 0.18g of gum arabic powder and dissolve in 90mL of deionized water. Adjust the pH of both solutions to 4.0 to obtain a wall material solution. Accurately weigh 0.05g of curcumin, 0.05g of Tween 80 and 0.05g of lecithin and dissolve them in 10mL of absolute ethanol, and accelerate the dissolution in a 50°C water bath to obtain the core material solution. Under high-speed stirring condition (800r / min), draw 3mL core material and add in 90mL chitosan solution (concentration 0.2%, pH4.0), add 90mL gum arabic solution (concentration 0.2%, pH4. 0). Stirring was continued for 10 min, and ethanol was removed by rotary evaporation at 40°C for 30 min. That is, the curcumin nanocomposite product is obtained. The measured average particle diameter is 353.9 nm...

Embodiment 2

[0020] Accurately weigh 0.20 g of chitosan and dissolve it in 100 mL of acetic acid with a concentration of 1% (v / v), stir until completely dissolved, prepare a 0.2% chitosan homogeneous solution, filter and set aside. Accurately weigh 0.20 g of gum arabic powder and dissolve in 100 mL of deionized water. Adjust the pH of both solutions to 4.0 to obtain a wall material solution. Prepare to weigh 0.05g of curcumin, 0.25g of Tween 80 and 0.25g of lecithin and dissolve them together in 10mL of absolute ethanol, and accelerate the dissolution in a 50°C water bath to obtain the core material solution. Under high-speed stirring condition (800r / min), draw 2mL core material and add in 60mL chitosan solution (concentration 0.2%, pH4.0), add 60mL gum arabic solution (concentration 0.2%, pH4. 0). Stirring was continued for 10 min, and ethanol was removed by rotary evaporation at 40°C for 30 min. That is, the curcumin nanocomposite product is obtained. The measured average particle di...

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Abstract

The invention discloses a curcumin nano compound and a preparation method thereof, and belongs to the technical field of functional health food. The curcumin nano compound is prepared from biodegradable chitosan and Arabia adhesive which used as a matrix by polyelectrolyte complexation reaction of the biodegradable chitosan and the Arabia adhesive. Specific steps are as follows: curcumin, lecithin and Twain 80 are commonly dissolved in absolute ethanol to use as a core material; under the conditions of stirring, the core material is filled into the chitosan, the chitosan is added dropwise with Arabia gum solution, and ethanol is removed by rotary evaporation to prepare the curcumin nano compound product. The prepared composite average diameter is in 250-360nm, the encapsulation rate is around 85%, after storage, the size distribution is remained relatively stable, and the curcumin retention rate is high. The invention provides a novel polysaccharide nano carrier which can effectively improve the water solubility of curcumin hydrophobic functional components.

Description

technical field [0001] The invention relates to a curcumin nanocomposite and a preparation method thereof, belonging to the technical field of functional health food. Background technique [0002] Curcumin is a plant polyphenol extracted from the traditional Chinese medicine turmeric. It is a rare pigment containing a diketone structure in the plant kingdom. It is an oil-soluble pigment, easily soluble in alkali, acetone, and chloroform, insoluble under acidic and neutral conditions, and unstable under alkaline conditions. As a food additive, curcumin is mainly used in the coloring of sausage products, canned food and sauce stewed products. Medical research shows that curcumin has various functional properties such as anti-inflammation, anti-oxidation, lowering blood fat, anti-atherosclerosis, and anti-tumor, and has no toxic side effects on the human body after ingestion. However, curcumin has poor water solubility, only 11ng / mL, and most of it is excreted from feces afte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23P1/04A23L33/00
CPCA23V2002/00A23V2200/30A23V2250/21
Inventor 夏书芹谢洁红张晓鸣谭晨贾承胜钟芳
Owner JIANGNAN UNIV
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