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Hydrolysis method of Qingkailing raw material

A technology of raw materials and hydrolysis time, which is applied to plant raw materials, unknown raw materials, medical raw materials derived from molluscs, etc., can solve the problems of complex process, low amino acid extraction rate, and restrictions on the production of Qingkailing products, and achieve high amino acid content, The effect of simplifying the process

Active Publication Date: 2015-01-14
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] The existing hydrolysis method has the problems of complex process and low amino acid extraction rate, which restricts the production of Qingkailing products

Method used

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  • Hydrolysis method of Qingkailing raw material

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Experimental program
Comparison scheme
Effect test

Embodiment

[0032] Grind 50g buffalo horn and 50g mother-of-pearl into a three-necked flask, add sulfuric acid while stirring, and heat to reflux. After the reaction is stabilized, the temperature is about 100°C. Timely mobilize the stirring speed to prevent bumping and reaction. After the hydrolysis reflux is completed, remove the reflux device, let it cool down, add 15% calcium hydroxide to adjust the pH value to about 4.0, filter, wash the residue with an appropriate amount of water, wash until the filtrate is almost colorless, combine the filtrates, and stand overnight at room temperature for later use .

[0033] Concentrate the filtrate, carry out alcohol precipitation on the concentrated solution, add about twice the amount of ethanol of the stock solution until the alcohol content is 60-62%. Stand at room temperature for no less than 24 hours, and set aside.

[0034] The alcoholic solution was filtered. Concentrate the filtrate, filter it while it is hot, place the filtrate at ...

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Abstract

The invention discloses a hydrolysis method of a Qingkailing raw material. The hydrolysis method is implemented by mixing mother-of-pearl with cornu bubali powder, and simultaneously carrying out heating reflux and hydrolysis on the obtained mixture, wherein the hydrolysis conditions are as follows: a sulfuric acid solution with a molar concentration of 2-8 mol / L is adopted, the material-solution ratio of the mixed powder to the sulfuric acid solution is 1 g: 2-8 ml, and the hydrolysis time is 3-10 hours. In the method, cornu bubali and mother-of-pearl are simultaneously hydrolyzed by using the sulfuric acid solution with an appropriate concentration, so that the process is simplified; and under the conditions, the content of an obtained active ingredient, namely amino acid, is high than those obtained by using existing methods.

Description

technical field [0001] The invention belongs to the field of preparation of Chinese patent medicines, and in particular relates to a method for hydrolyzing Qingkailing raw materials. Background technique [0002] Qingkailing series products are composed of extracts of honeysuckle, isatis root, gardenia, buffalo horn, mother of pearl, baicalin, cholic acid and hyodeoxycholic acid. Function, widely used in the treatment of fever, coma, upper respiratory tract infection, pneumonia and high fever and other diseases. Modern pharmacological research shows that polypeptides and amino acids are the active ingredients of the above-mentioned eight herbs. In buffalo horn and mother-of-pearl powder, the main active ingredients are amino acids. In the prior art, the processing methods of buffalo horn and mother-of-pearl are extracted by different hydrolysis methods. Generally, buffalo horn powder is hydrolyzed with barium hydroxide solution, and mother-of-pearl powder is hydrolyzed wit...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K35/32A61K36/744
CPCA61K35/32A61K35/618A61K2236/331A61K2236/53A61K2300/00
Inventor 保冰怡王家祺黄孟秋黄子健司徒少金
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD