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Preparation and quality control method of liquorice formula granules

A technology of formula granules and licorice, which is applied in the field of preparation and quality control of licorice formula granules, and can solve the problems of different content of chemical components, insignificant difference of first-level infrared fingerprints, interference and the like

Inactive Publication Date: 2015-01-14
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The experimental research found that the chemical composition content of different varieties of licorice is different, and the first-level infrared fingerprints of different varieties of licorice medicinal materials and licorice formula granules measured by direct compression method are not obvious, and the formula granules are also affected by the added dextrin excipients. Interference, it is difficult to distinguish between different varieties of licorice medicinal materials and licorice formula granules

Method used

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  • Preparation and quality control method of liquorice formula granules
  • Preparation and quality control method of liquorice formula granules
  • Preparation and quality control method of liquorice formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1: Ural licorice was used as raw material, the following steps were used to prepare licorice formula granules, and its infrared fingerprint was determined.

[0056] Take 215 kg of licorice decoction pieces, chop them up, add water to decoct three times, add 1720 L of water each time, heat and decoct for 1.5 hours each time; combine the three decoctions, concentrate the filtrate to a clear paste with a relative density of 1.08 (80°C), and store it while Filter the heat with a 350-mesh sieve, put it in a batching tank; spray and dry it under the conditions of an inlet air temperature of 175°C, a material pump speed of 500 rpm, an outlet air temperature of 90°C, and an air supply temperature of 40°C to obtain licorice spray-dried powder 485.80kg; dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 45Hz, oil cylinder pressure 20bar, and finally licorice formula granules with a particle size of 1...

Embodiment 2

[0059] Example 2: Carry out quality control on the licorice (Ural) medicinal material in the implementation case 1 using infrared fingerprints, the steps are as follows: Weigh 0.5g of medicinal material powder, add 20ml of absolute ethanol, ultrasonically extract for 30min, filter, and take the subsequent filtrate to concentrate to 1ml to obtain a sample solution. Pipette 0.1ml of the sample solution, add it dropwise on 100mg of fully ground potassium bromide powder, place it in an electric furnace and dry it at a constant temperature of 80°C for 3 minutes, take it out, grind it fully and press it into tablets for sample preparation. Measured by Fourier transform infrared spectrometer, measuring conditions: the measuring range is 4000cm -1 -400cm -1 , DTGS detector, resolution 4cm -1 , The number of scans is 16 times, the interference of water and carbon dioxide is deducted in real time during the scanning process, and the relative humidity of the environment is lower than 6...

Embodiment 3

[0061] Example 3: The quality control of the intermediate product licorice spray-dried powder in the preparation process of the licorice formula granules in Example 1 is carried out using infrared fingerprints. The steps are as follows: Weigh 0.5 g of the medicinal material powder, add 20 ml of absolute ethanol, ultrasonically extract for 30 minutes, and filter , Concentrate the filtrate to 1ml to obtain a sample solution. Pipette 0.1ml of the sample solution, add it dropwise on 100mg of fully ground potassium bromide powder, place it in an electric furnace and dry it at a constant temperature of 80°C for 3 minutes, take it out, grind it fully and press it into tablets for sample preparation. Measured by Fourier transform infrared spectrometer, measuring conditions: the measuring range is 4000cm -1 -400cm -1 , DTGS detector, resolution 4cm -1 , The number of scans is 16 times, the interference of water and carbon dioxide is deducted in real time during the scanning process, ...

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Abstract

The invention discloses a preparation method of liquorice formula granules and a quality control method for quickly detecting finished liquorice formula granule products, raw medicinal materials and intermediate products. The liquorice formula granules are prepared by performing the technological processes such as water extraction, decompression concentration and spray drying on liquorice serving as a raw material to obtain liquorice spray-dried powder and directly drying the liquorice powder or adding a proper quantity of auxiliary materials for mixing; each gram of the liquorice formula granules is equal to 3 grams of raw medicines. According to the method, the liquorice formula granules or the raw medicinal martials or an ethyl alcohol extract of spray-dried powder are or is tabletted with potassium bromide to prepare a sample, and then a Fourier transformation infrared spectrometer is used for performing infrared measurement on tablets to obtain infrared characterization fingerprints to realize quick detection and quality control on the finished liquorice formula granule products, the raw medicinal materials and the intermediate products, so that the stability and the reliability of the liquorice formula granule production technology are guaranteed. The quality control method disclosed by the invention is scientific, advanced, quick, economical and specific and is high in operability.

Description

technical field [0001] The invention relates to a preparation and quality control method of licorice formula granules, in particular to a preparation method of licorice formula granules and rapid infrared fingerprinting of licorice formula granules, raw medicinal materials for preparing licorice formula granules, and intermediate products prepared from licorice formula granules. Testing and quality control methods. Background technique [0002] Traditional Chinese medicine formula granules are refined by extracting, concentrating, drying, and granulating traditional Chinese medicine decoction pieces through modern pharmaceutical technology under the guidance of the theory of traditional Chinese medicine. control, easy to carry and so on. The formula granules are mostly prepared by the traditional decoction water extraction method. Because the shape of the original decoction pieces is changed, new requirements are put forward for quality control. [0003] The 2010 edition o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3563A61K36/484A61K9/16
Inventor 谭登平朱德全兰小勇张光大陈向东
Owner GUANGDONG YIFANG PHARMA
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