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GrcVillic acid and applications of GrcVillic acid, hydroquinone and Heliciopsis lobata active ingredients in preparation of anti-tumor and anti-inflammation drugs

A technology of active components and anti-inflammatory drugs, which is applied in the application field of preparing anti-tumor and anti-inflammatory drugs, can solve the problem of poor long-term effect of anti-tumor drugs, large toxic and side effects, and unclear active components of Hainan Longan. question

Inactive Publication Date: 2015-02-04
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems that the existing anti-tumor drugs have poor long-term effects, high toxic and side effects, and unclear active components of Hainan longan longan, the present invention provides a kind of silver betulinic acid, silver betulinic acid, hydroquinone and Hainan split leaf The application of the active components of Longan Yeshan in the preparation of anti-tumor and anti-inflammatory drugs, for the first time, it was determined that the main components of the active components of Longan Longan in Hainan that have anti-tumor and anti-inflammatory activities are silver betulinic acid and hydroquinone

Method used

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  • GrcVillic acid and applications of GrcVillic acid, hydroquinone and Heliciopsis lobata active ingredients in preparation of anti-tumor and anti-inflammation drugs
  • GrcVillic acid and applications of GrcVillic acid, hydroquinone and Heliciopsis lobata active ingredients in preparation of anti-tumor and anti-inflammation drugs
  • GrcVillic acid and applications of GrcVillic acid, hydroquinone and Heliciopsis lobata active ingredients in preparation of anti-tumor and anti-inflammation drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of Active Components of Hainan Longan Longan by Water Extraction-Ethyl Acetate Extraction

[0050] The leaf / stem bark / root bark / flower / fruit coarse powder of Hainan Longan Longan is extracted by water decoction, the extract is concentrated to obtain the water extract extract, and the extract is dissolved and extracted with ethyl acetate to obtain the active component . Specific steps are as follows:

[0051] (a) dry the leaf / stem bark / root bark / flower / fruit of Hainan Longan Longan in the shade, and pulverize to obtain the coarse powder of 250g leaf / stem bark / root bark / flower / fruit;

[0052] (b) The coarse powder of leaf / stem bark / root bark / flower / fruit obtained in step (a) is extracted by decocting, and the amount of water added is the coarse powder of leaf / stem bark / root bark / flower / fruit. 10 times the volume of the powder, heated and boiled to extract 3 times, 3 hours each time, the extracts were filtered and combined, concentrated under reduced pressure...

Embodiment 2

[0059] Preparation of Active Components of Hainan Longan Longan by Water Extraction-Macroporous Adsorption Resin

[0060] The leaf / stem bark / root bark / flower / fruit coarse powder of Hainan Longan Longan is extracted by water decoction, the extract is concentrated to obtain a water extract extract, the extract is dissolved in water, passed through a macroporous adsorption resin chromatographic column, and used Ethanol with a concentration of 30% to 50% is used for gradient elution, and the different gradient eluents are combined and then concentrated under reduced pressure to obtain the active component. Specific steps are as follows:

[0061] (a) dry the leaf / stem bark / root bark / flower / fruit of Hainan Longan Longan in the shade, and pulverize to obtain the coarse powder of 250g leaf / stem bark / root bark / flower / fruit;

[0062] (b) The coarse powder of leaf / stem bark / root bark / flower / fruit obtained in step (a) is extracted by decocting, and the amount of water added is the coarse...

Embodiment 3

[0069] 30% Alcohol Extraction-Ethyl Acetate Extraction to Prepare the Active Components of Longan Longan

[0070] The leaf / stem bark / root bark / flower / fruit coarse powder of Hainan Longan Longan is reflux extracted with 30% ethanol solution, the extract is concentrated to obtain an extract, and the extract is dissolved and then extracted with ethyl acetate to obtain active components. Specific steps are as follows:

[0071] (a) dry the leaf / stem bark / root bark / flower / fruit of Hainan Longan Longan in the shade, and pulverize to obtain the coarse powder of 250g leaf / stem bark / root bark / flower / fruit;

[0072] (b) adopt alcohol extraction to extract the coarse powder of leaf / stem bark / root bark / flower / fruit obtained in step (a), the volume concentration of ethanol is 30%, the addition of ethanol is leaf / stem bark / 10 times the volume of the root bark / flower / fruit coarse powder, reflux extraction 3 times, 3 hours each time, the extracts were filtered and combined, concentrated unde...

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Abstract

The present invention discloses a GrcVillic acid and applications of the GrcVillic acid, hydroquinone and Heliciopsis lobata active ingredients in preparation of anti-tumor and anti-inflammation drugs, and belongs to the field of medicine. The applications comprise the application of the GrcVillic acid in preparation of anti-tumor and anti-inflammation drugs, the application of the GrcVillic acid and the hydroquinone in preparation of anti-tumor and anti-inflammation drugs, and the application of the Heliciopsis lobata active ingredients in preparation of anti-tumor and anti-inflammation drugs, wherein the tumors are the primary / secondary cancers or sarcomas derived from human stomach, liver, lung, nose, skin, head and neck, thyroid, pancreas, esophagus, breast, kidney, gall bladder, colon / rectum, ovary, uterus, cervix, prostate, bladder and testis. The GrcVillic acid of the present invention provides the good treatment effects in the treatment of the primary / secondary cancers or sarcomas, and has the low toxic-side effects.

Description

technical field [0001] The invention belongs to the field of medicines, and more specifically relates to the application of ginkulin, ginkulin, hydroquinone and the active components of Hainan Longan longan in the preparation of antitumor and anti-inflammatory drugs. Background technique [0002] As we all know, tumor has become one of the most serious diseases that threaten human life and health, and more than nine million people in the world suffer from malignant tumors every year. In my country, there are about 2 million new cases and more than 1.4 million deaths every year. By 2020, these numbers may continue to grow. In the world, 22 million of the 5.2 billion people suffer from cancer. The number of new patients will continue to rise in the next 20 years, and the number of deaths from cancer will only increase. Therefore, finding effective drugs and methods for the prevention and treatment of cancer has become an urgent task in today's society. At present, anti-tumor...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K36/185A61P29/00A61P35/00A61K31/05
Inventor 徐寒梅欧娜梁其冰
Owner CHINA PHARM UNIV
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