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Construction of spinal cord tissues for repairing spinal cord injuries

A spinal cord injury and spinal cord technology, applied in the field of construction of spinal cord-like tissue, can solve the problems of inability to integrate nerve fibers, inability to wrap cells more effectively, and disorderly distribution, etc., to promote social and economic development, prolong human lifespan, The effect of reducing social and family burden

Inactive Publication Date: 2015-02-18
SUN YAT SEN UNIV
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  • Abstract
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Problems solved by technology

[0004] However, we are still facing the key scientific problem of spinal cord injury repair that has not been solved well: that is, in the previously constructed stem cell-derived neural network, the distribution of neurons and myelin-forming cells is random and disordered, which may lead to The regenerated nerve fibers do not integrate quickly and accurately with the transplanted neural network, or the myelin-forming cells do not more efficiently wrap the axons of neurons requiring myelination

Method used

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  • Construction of spinal cord tissues for repairing spinal cord injuries

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Embodiment Construction

[0008] The main instruments used in the present invention, degradable biomaterials, degradable polymer materials, experimental cells and reagents are described in detail below by specific examples:

[0009] 1. Main instruments

[0010] Ultra-clean workbench (Suzhou Purification Electronic Equipment Factory); ordinary centrifuge (Kubota Japan); constant temperature water bath box (Beijing Medical Equipment Factory); 5% CO 2 Incubator (Queue USA); Inverted Phase Contrast Microscope (Olympus Japan); Fluorescence Microscope (Leica Germany); Scanning Electron Microscope (Philips Netherlands); Transmission Electron Microscope (Philips Netherlands); Laser Confocal Imaging System (Carl Zeiss Germany); Low Temperature Oven ( Shanghai Yuejin Medical Instrument Factory); high temperature oven (Shanghai Yuejin Medical Instrument Factory); high pressure sterilizer (Jiangyin Binjiang Medical Equipment Factory); constant cold box slicer (Shandon UK); ultrapure water instrument (Molsheim Fran...

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Abstract

The invention relates to a construction method of spinal cord tissues for repairing spinal cord injuries, in particular to a construction method for spinal cord tissues containing white matter structures on the periphery and grey matter structures in the center. When the construction method is used, the constructed spinal cord tissues containing white matter structure stem cell-derived oligodendroglia cells and grey matter structure stem cell-derived nerve cells are transplanted to transverse spinal cord injuries, and are integrated in a host neural network in a matching mode that a white matter structure corresponds to host white matters and a grey matter structure corresponds to host grey matters, so that the regeneration and functional repair of injured spinal cords are better promoted.

Description

technical field [0001] The invention relates to a method for constructing a myeloid-like tissue for repairing spinal cord injury, in particular to a method for constructing a myeloid-like tissue with a surrounding white matter-like structure and a central gray matter-like structure. Background technique [0002] In the research field of spinal cord injury repair, the combined use of stem cells, neurotrophic factors and biomaterials has shown encouraging results. However, current combination therapy strategies either solely emphasize the role of replacement neurons or solely emphasize the repairing role of transplanted myelinating cells. None of these are sufficient for functional restoration of spinal cord injuries. Our previous studies were based on the massive loss of neurons and myelinating cells after spinal cord injury. Using Schwann cells (SCs) overexpressing neurotrophin-3 (neurotrophin-3, NT-3) and neural stem cells (NSCs) overexpressing NT-3 receptor TrkC on three...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/38A61L27/54A61L27/56
Inventor 曾园山赖碧琴
Owner SUN YAT SEN UNIV
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