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3D (three-dimensional) printing porous metal stent of composite magnetic nano material and preparation method of 3D printing porous metal stent

A technology of porous metal and nanomaterials, applied in the field of biomedical materials, can solve the problems of lack of biological activity, insufficient mechanical strength, small application range, etc., and achieve the effect of strong mechanical strength

Active Publication Date: 2015-02-18
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 3D printed porous metal scaffold of the composite magnetic nanomaterial not only overcomes the defect that the porous metal scaffold lacks biological activity, but also overcomes the defect that the mechanical strength of the biodegradable material is insufficient and the application range is small

Method used

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  • 3D (three-dimensional) printing porous metal stent of composite magnetic nano material and preparation method of 3D printing porous metal stent
  • 3D (three-dimensional) printing porous metal stent of composite magnetic nano material and preparation method of 3D printing porous metal stent
  • 3D (three-dimensional) printing porous metal stent of composite magnetic nano material and preparation method of 3D printing porous metal stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of 3D printed porous metal scaffolds of composite magnetic nanomaterials

[0054] 1. Preparation of porous titanium alloy scaffold

[0055] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 100 μm and the pore diameter is 300 μm. Personalized porous connected 3D digital model (such as figure 1 shown).

[0056] (2) EOS M280 metal material 3D printer was used to print porous titanium alloy scaffolds (such as figure 2 shown).

[0057] 2. Preparation of the mixture of magnetic particles, natural polymer materials and bioceramics

[0058] (1) Add 1.5% w / v gelatin particles into deionized water and soak for 2 hours, and at the same time stir at 37° C. with a magnetic stirrer at 300 r / min until completely dissolved.

[0059] (2) Nano-hydroxyapatite powder nHA (diameter 20nm) and γ-Fe 2 o 3 Added to gelatin solution, wherein t...

Embodiment 2

[0065] Example 2 Preparation of 3D printed porous metal scaffolds of composite magnetic nanomaterials

[0066] 1. Preparation of porous titanium alloy scaffold

[0067] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 300 μm and the pore diameter is 1000 μm. Personalized porous connected 3D digital model (such as figure 1 shown).

[0068] (2) EOS M280 metal material 3D printer was used to print porous titanium scaffolds (such as figure 2 shown).

[0069] 2. Preparation of the mixture of magnetic particles, natural polymer materials and bioceramics

[0070] (1) Add 3% w / v gelatin particles into deionized water and soak for 2 hours, and at the same time stir at 37° C. with a magnetic stirrer at 300 r / min until completely dissolved.

[0071] (2) Nano-hydroxyapatite powder nHA (diameter 20nm) and γ-Fe 2 o 3 Added to gelatin solution, wherein the mass...

Embodiment 3

[0077] Example 3 Preparation of 3D printed porous metal scaffolds of composite magnetic nanomaterials

[0078] 1. Preparation of porous titanium alloy scaffold

[0079] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 1000 μm and the pore diameter is 3000 μm. Personalized porous connected 3D digital model (such as figure 1 shown).

[0080] (2) EOS M280 metal material 3D printer was used to print porous titanium scaffolds (such as figure 2 shown).

[0081] 2. Preparation of the mixture of magnetic particles, natural polymer materials and bioceramics

[0082] (1) Add 5% w / v gelatin particles into deionized water and soak for 2 hours, and at the same time, stir at 37° C. with a magnetic stirrer at 300 r / min until completely dissolved.

[0083] (2) Nano-hydroxyapatite powder nHA (diameter 20nm) and γ-Fe 2 o 3 Added to gelatin solution, wherein the ma...

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Abstract

The invention discloses a 3D (three-dimensional) printing porous metal stent of a composite magnetic nano material and a preparation method of the 3D printing porous metal stent. A composite porous metal stent consists of a porous metal stent and a 3D micro-stent which is prepared from magnetic particles, natural polymer materials and biological ceramics and is positioned in the porous metal stent. The preparation method comprises the following steps: preparing the magnetic particles, the natural polymer materials and the biological ceramics into a coagulation fluid, injecting the coagulation fluid into the pores of the porous metal stent, and preparing the 3D printing porous metal stent of the composite magnetic nano material by virtue of a freeze drying process. The 3D printing porous metal stent of the composite magnetic nano material, disclosed by the invention, can be used for repairing and treating bone defects of large load-bearing parts clinically.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a 3D printed porous metal scaffold composited with magnetic nanomaterials and a preparation method thereof, in particular to a composite three-dimensional microstent composed of bioceramic materials, natural polymer materials, and magnetic particles Porous metal scaffold and method for its preparation. Background technique [0002] Bone defect caused by disease and trauma is a common clinical disease and one of the worldwide problems in orthopedic treatment, seriously affecting the quality of life of patients. At present, the methods for treating bone defects include autologous bone and allogeneic bone transplantation, biodegradable biomaterials and medical metal material transplantation, and tissue engineering techniques. Although autologous bone is good, its source is limited, and it will bring unnecessary secondary trauma to patients; allogeneic bone also has disadvantages s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/22A61L27/10A61L27/02
Inventor 尹博王海许海燕刘健马培吴志宏邱贵兴
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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