Preparation method of ginkgolide L

Abstract

A ginkgolide type compound which serves as a powerful antagonist of platelet activating factors (PAF) has very good protective effects on focal cerebral ischemia and diffuse total cerebral ischemia. Ginkgolide is divided into ginkgolide A, ginkgolide B, ginkgolide C, bilobalide, ginkgolide K, ginkgolide L and the like. The content of ginkgolide L in ginkgo leaves is extremely low, so that ginkgolide L is difficult to obtain, and research report on ginkgolide L is nearly zero. The invention relates to a preparation method of ginkgolide L. Ginkgolide L is extracted from commercially available ginkgo total lactone or ginkgo total lactone obtained based on a known method. The preparation method is simple to operate, the raw materials are low in cost, a plenty of ginkgolide L can be obtained rapidly, and basis is provided for research on ginkgolide L.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of ginkgolide L. Background technique

[0002] Ginkgo biloba L. is the only living species of Ginkgo biloba in the family Ginkgoaceae. It is known as the "living fossil" of the plant kingdom and is one of the unique ancient trees in my country. Ginkgo biloba has the functions of astringing the lung, relieving asthma, promoting blood circulation and removing blood stasis, and relieving pain. It is used to treat cough due to lung deficiency, coronary heart disease, angina pectoris, and hyperlipidemia. The main components of Ginkgo biloba standard extract are 22%-24% flavonoids and 5%-7% lactones.

[0003] In 1967, the team of Professor Nakashi Xianger of Columbia University in the United States reported several compounds found in Ginkgo biloba extract, among which four diterpene lactones with special structures ( diterpene lactones) compounds nam...

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