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Composite 3D printing porous metal support for demineralized bone matrix and preparation method of metal support

A decalcified bone matrix and 3D printing technology, applied in the field of biomedical materials, can solve the problems of unfavorable cell adhesion, inability to realize three-dimensional microenvironment cell culture, difficulty in achieving cell growth, matrix secretion and filling, etc., to achieve The effect of maximizing bone ingrowth

Active Publication Date: 2015-02-25
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The 3D printed porous titanium alloy scaffolds currently on the market have an internal diameter of about 300-1500 μm, which is relatively open and not conducive to the attachment of relatively small cells. Most of them can only adhere to the wall and grow in two-dimensional space, and cannot achieve three-dimensional stereoscopic Cell Culture in Microenvironments
Although there have been studies on the two-dimensional activation modification of the inner surface of the porous titanium pores, such as acid-base treatment on the surface, plasma spray coating on the surface, and growth factors loaded on the surface, it is still difficult to realize the three-dimensional layer of cells. Growth and matrix secretion and filling

Method used

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  • Composite 3D printing porous metal support for demineralized bone matrix and preparation method of metal support
  • Composite 3D printing porous metal support for demineralized bone matrix and preparation method of metal support
  • Composite 3D printing porous metal support for demineralized bone matrix and preparation method of metal support

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Preparation of 3D printed porous metal scaffold of composite decalcified bone matrix

[0058] 1. Preparation of porous titanium alloy scaffold

[0059] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 100 μm and the pore diameter is 300 μm. Personalized porous connected 3D digital model (such as figure 1 shown).

[0060] (2) EOS M280 metal material 3D printer was used to print porous titanium scaffolds (such as figure 2 shown).

[0061] 2. Preparation of decalcified bone matrix

[0062] (1) Take some corpses of New Zealand white rabbits, and cut off their limbs;

[0063] (2) Separate the bones and tissues of the limbs, and remove the periosteum, cartilage and tissues on the surface;

[0064] (3) The obtained limb bones were washed and stored in a -80°C refrigerator for later use;

[0065] (4) Take some New Zealand white rabbit li...

Embodiment 2

[0077] Example 2 Preparation of 3D printed porous metal scaffold of composite decalcified bone matrix

[0078] 1. Preparation of porous titanium alloy scaffold

[0079] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 300 μm and the pore diameter is 1000 μm. Personalized porous connected 3D digital model (such as figure 1 shown).

[0080] (2) EOS M280 metal material 3D printer was used to print porous titanium scaffolds (such as figure 2 shown).

[0081] 2. Preparation of decalcified bone matrix

[0082] (1) Take some corpses of New Zealand white rabbits, and cut off their limbs;

[0083] (2) Separate the bones and tissues of the limbs, and remove the periosteum, cartilage and tissues on the surface;

[0084] (3) The obtained limb bones were washed and stored in a -80°C refrigerator for later use;

[0085] (4) Take some New Zealand white rabbit l...

Embodiment 3

[0097] Example 3 Preparation of 3D printed porous metal scaffold of composite decalcified bone matrix

[0098] 1. Preparation of porous titanium alloy scaffold

[0099] (1) Import the CT image into three-dimensional image software such as Mimics or CAD to obtain a three-dimensional image of the target bone tissue. The average pore column is 1000 μm and the pore diameter is 3000 μm. Personalized porous connected 3D digital model (such as figure 1 shown).

[0100] (2) EOS M280 metal material 3D printer was used to print porous titanium scaffolds (such as figure 2 shown).

[0101] 2. Preparation of decalcified bone matrix

[0102] (1) Take some corpses of New Zealand white rabbits, and cut off their limbs;

[0103] (2) Separate the bones and tissues of the limbs, and remove the periosteum, cartilage and tissues on the surface;

[0104] (3) The obtained limb bones were washed and stored in a -80°C refrigerator for later use;

[0105] (4) Take some New Zealand white rabbit ...

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Abstract

The invention discloses a composite 3D printing porous metal support for a demineralized bone matrix and a preparation method of the metal support. The composite 3D printing porous metal support for the demineralized bone matrix consists of a demineralized bone matrix and a porous titanium alloy support. The composite 3D printing porous metal support is prepared by injecting demineralized bone matrix particle coagulation fluid into the porous titanium alloy support, and a three-dimensional micro support in the composite porous titanium alloy support is formed by virtue of the demineralized bone matrix. The composite 3D printing porous metal support for the demineralized bone matrix disclosed by the invention can be used for clinical repair and treatment of bone defect on a massive bearing part.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a 3D printed porous metal scaffold composited with decalcified bone matrix and a preparation method thereof, in particular to a porous titanium alloy scaffold composited with a decalcified bone matrix three-dimensional micro-stent and a preparation method thereof. Background technique [0002] Clinically, the graft materials for bone defects mainly include autologous bone and allogeneic bone. Although autologous bone transplantation has less rejection and faster cell expansion, it is easily affected by the site where the material is obtained, resulting in less bone extraction and trauma to the individual. Bone allografts are often restricted by factors such as biocompatibility, graft infection, and allergies. Various biomaterials that have emerged in recent years, such as polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), calcium phosphate (TCP), etc., have good biocomp...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/06A61L27/56A61L27/36
Inventor 朱威尹博吴志宏邱贵兴
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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