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A 3D printed porous metal scaffold with composite decalcified bone matrix and its preparation method

A decalcified bone matrix and 3D printing technology, which is applied in the field of biomedical materials, can solve the problems of unfavorable cell attachment, difficulty in achieving cell growth, matrix secretion and filling, and inability to achieve three-dimensional microenvironment cell culture. The effect of maximizing bone ingrowth

Active Publication Date: 2016-08-17
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The 3D printed porous titanium alloy scaffolds currently on the market have an internal diameter of about 300-1500 μm, which is relatively open and not conducive to the attachment of relatively small cells. Most of them can only adhere to the wall and grow in two-dimensional space, and cannot achieve three-dimensional stereoscopic Cell Culture in Microenvironments
Although there have been studies on the two-dimensional activation modification of the inner surface of the porous titanium pores, such as acid-base treatment on the surface, plasma spray coating on the surface, and growth factors loaded on the surface, it is still difficult to realize the three-dimensional layer of cells. Growth and matrix secretion and filling

Method used

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  • A 3D printed porous metal scaffold with composite decalcified bone matrix and its preparation method
  • A 3D printed porous metal scaffold with composite decalcified bone matrix and its preparation method
  • A 3D printed porous metal scaffold with composite decalcified bone matrix and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Preparation of 3D printed porous metal scaffold with composite demineralized bone matrix

[0058] 1. Preparation of porous titanium alloy scaffold

[0059] (1) Import the CT image into 3D imaging software such as Mimics or CAD to obtain a 3D image of the target bone tissue. The average pore column is 100μm and the pore diameter is 300μm. Fill and expand the image with regular hexahedron and regular dodecahedron structure units. Personalized three-dimensional digital model of porous connectivity (such as figure 1 Shown).

[0060] (2) Using EOS M280 metal material 3D printer, using titanium alloy (Ti-6Al-4V) as raw material, printing porous titanium stents (such as figure 2 Shown).

[0061] 2. Preparation of decalcified bone matrix

[0062] (1) Take several corpses of New Zealand white rabbits and cut off their limbs;

[0063] (2) Separate the bones and tissues of the limbs, and remove the surface periosteum, cartilage and tissues;

[0064] (3) The obtained limb bones are...

Embodiment 2

[0077] Example 2 Preparation of 3D printed porous metal scaffold with composite demineralized bone matrix

[0078] 1. Preparation of porous titanium alloy scaffold

[0079] (1) Import the CT image into 3D image software such as Mimics or CAD to obtain a 3D image of the target bone tissue. The average pore column is 300μm and the pore diameter is 1000μm. Fill and expand the image with regular hexahedron and regular dodecahedron structure units. Personalized three-dimensional digital model of porous connectivity (such as figure 1 Shown).

[0080] (2) Using EOS M280 metal material 3D printer, using titanium alloy (Ti-6Al-4V) as raw material, printing porous titanium stents (such as figure 2 Shown).

[0081] 2. Preparation of decalcified bone matrix

[0082] (1) Take several corpses of New Zealand white rabbits and cut off their limbs;

[0083] (2) Separate the bones and tissues of the limbs, and remove the surface periosteum, cartilage and tissues;

[0084] (3) The obtained limb bones are ...

Embodiment 3

[0097] Example 3 Preparation of 3D printed porous metal scaffold with composite demineralized bone matrix

[0098] 1. Preparation of porous titanium alloy scaffold

[0099] (1) Import the CT image into 3D image software such as Mimics or CAD to obtain a 3D image of the target bone tissue. The average pore column is 1000μm and the pore size is 3000μm. Fill and expand the image with regular hexahedron and regular dodecahedron structure units. Personalized three-dimensional digital model of porous connectivity (such as figure 1 Shown).

[0100] (2) Using EOS M280 metal material 3D printer, using titanium alloy (Ti-6Al-4V) as raw material, printing porous titanium stents (such as figure 2 Shown).

[0101] 2. Preparation of decalcified bone matrix

[0102] (1) Take several corpses of New Zealand white rabbits and cut off their limbs;

[0103] (2) Separate the bones and tissues of the limbs, and remove the surface periosteum, cartilage and tissues;

[0104] (3) The obtained limb bones are was...

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Abstract

The invention discloses a composite 3D printing porous metal support for a demineralized bone matrix and a preparation method of the metal support. The composite 3D printing porous metal support for the demineralized bone matrix consists of a demineralized bone matrix and a porous titanium alloy support. The composite 3D printing porous metal support is prepared by injecting demineralized bone matrix particle coagulation fluid into the porous titanium alloy support, and a three-dimensional micro support in the composite porous titanium alloy support is formed by virtue of the demineralized bone matrix. The composite 3D printing porous metal support for the demineralized bone matrix disclosed by the invention can be used for clinical repair and treatment of bone defect on a massive bearing part.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and relates to a 3D printed porous metal scaffold with a composite demineralized bone matrix and a preparation method thereof, and in particular to a porous titanium alloy scaffold with a composite decalcified bone matrix three-dimensional micro-scaffold and a preparation method thereof. Background technique [0002] Clinically, the graft materials for bone defects are mainly autologous bone and allogeneic bone. Although autologous bone transplantation has a smaller rejection reaction and faster cell expansion, it is susceptible to the influence of the location of the material, resulting in less bone removal and easy to cause trauma to the individual. Allogeneic bone transplantation is often restricted by factors such as biocompatibility, graft infection, and allergies. Various biological materials that have emerged in recent years, such as polylactic acid (PLA), polylactic acid-glycolic acid copo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/06A61L27/56A61L27/36
Inventor 朱威尹博吴志宏邱贵兴
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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