Traditional Chinese medicine composition for treating H1N1 flu induced viral lung injury and preparation method of traditional Chinese medicine composition

A viral and compositional technology, applied in drug combinations, antiviral agents, pharmaceutical formulations, etc., can solve the problems of high infectivity, high variability, and difficulty in vaccine immunity to achieve protective effects, etc., to achieve obvious curative effect and no toxic side effects Effect

Active Publication Date: 2015-03-04
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Respiratory virus infection (RVI) caused by influenza virus has the characteristics of high infectivity and high variability, it is difficult to achieve complete protection by vaccine immunity, and the incidence of this disease has been increasing in recent years

Method used

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  • Traditional Chinese medicine composition for treating H1N1 flu induced viral lung injury and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating H1N1 flu induced viral lung injury and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating H1N1 flu induced viral lung injury and preparation method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] Example 1 (granules)

[0023] 1. Prescription:

[0024] Gang Meigen 30kg, Patchouli 10kg, Notopterygium 10kg, Bupleurum 10kg, Safflower 10kg, Honeysuckle 10kg, Fangfeng 10kg, Nepeta 10kg, Forsythia 15kg, Atractylodes 9kg, Peach Kernel 10kg, Artificial Bezoar 0.35kg.

[0025] 2. Preparation method:

[0026] see figure 1 ,

[0027] Crush patchouli, notopterygia, safflower, honeysuckle, windproof, Nepeta, herb, forsythia and peach kernel, and pass through a 20-mesh sieve. Use supercritical carbon dioxide extraction (extraction pressure 18mpa, temperature, 60 ℃, analysis pressure, 10mpa) wherein the volatile oil and fatty oil, use grinding and other methods to prepare the extracted volatile oil and fatty oil into β-cyclodextrin inclusion compound, Freeze-dried powder A. The above-mentioned medicinal residues of extracted volatile oil and fatty oil are mixed with Gangmeigen and Bupleurum, added with 8 times the amount of distilled water to extract twice, filtered, and t...

example 2

[0030] Example 2 (capsules)

[0031] 1. Prescription:

[0032] Gang Meigen 40kg, Patchouli 20kg, Notopterygium 15kg, Bupleurum 20kg, Safflower 10kg, Honeysuckle 10kg, Fangfeng 10kg, Nepeta 10kg, Forsythia 15kg, Atractylodes 9kg, Peach Kernel 10kg, Artificial Bezoar 0.35kg.

[0033] 2. Preparation method:

[0034] see figure 1, ground patchouli, notopterygium, safflower, honeysuckle, windproof, nepeta, herb, forsythia and peach kernel, sieved 20 meshes, and extracted with supercritical carbon dioxide (extraction pressure 18mpa, temperature, 60°C, analytical pressure, 10mpa ), wherein the volatile oil and fatty oil are prepared into β-cyclodextrin inclusion compound by grinding and other methods, and freeze-dried to obtain powder A; Add 8 times the amount of distilled water to extract the plum root and Bupleurum radix twice, filter and combine the filtrates. Vacuum concentration, spray drying, to obtain powder B, mix powder A and powder B, sieve, add artificial bezoar and au...

example 3

[0037] Example 3 (tablet)

[0038] 1. Prescription:

[0039] Gang Meigen 20kg, Patchouli 10kg, Notopterygium 10kg, Bupleurum 10kg, Safflower 20kg, Honeysuckle 20kg, Fangfeng 10kg, Nepeta 10kg, Forsythia 15kg, Atractylodes 15kg, Peach Kernel 20kg, Artificial Bezoar 0.35kg.

[0040] 2. Preparation method:

[0041] see figure 1 , ground patchouli, notopterygium, safflower, honeysuckle, windproof, nepeta, herb, forsythia and peach kernel, sieved 20 meshes, and extracted with supercritical carbon dioxide (extraction pressure 18mpa, temperature, 60°C, analytical pressure, 10mpa ), wherein the volatile oil and fatty oil are prepared into β-cyclodextrin inclusion compound by grinding and other methods, and freeze-dried to obtain powder A; Add 5 times the amount of distilled water to extract the plum root and Bupleurum radix twice, filter and combine the filtrates. Vacuum concentration, spray drying to obtain powder B, mix powder A and powder B, sieve, add artificial bezoar and aux...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating H1N1 flu induced viral lung injury. The composition is prepared from active ingredients and medically acceptable accessories, wherein the active ingredients are prepared from the following raw materials in parts by weight: 20-40 parts of roughhaired holly root, 10-20 parts of cablin potchouli herb, 5-15 parts of incised notopterygium, 10-20 parts of radix bupleuri, 8-20 parts of safflower, 10-20 parts of honeysuckle, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of fineleaf schizonepeta herb, 9-20 parts of weeping forsythiae capsule, 5-15 parts of atratylodes rhizome, 8-20 parts of peach kernel and 0.35-1 part of artificial cow-bezoar. The traditional Chinese medicine composition has the effects of expelling evil and relieving exterior syndrome, detoxifying and facilitating lung, resolving phlegm and removing stasis, and the like, and can be applied to treatment of the H1N1 flu induced viral lung injury.

Description

field of invention [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine preparation containing an undetermined structure from a plant of the family Ilex, which is suitable for treating viral lung injury caused by H1N1 influenza. technical background [0002] Respiratory virus infection (RVI) caused by influenza virus is characterized by high infectivity and variability, and it is difficult for vaccine immunity to achieve complete protection, and the incidence of this disease has been increasing in recent years. However, the development of RVI into acute lung injury (Acute lung injury, ALI) and acute respiratory distress syndrome (Acute Respiratory Distress Syndrome, ARDS) is the main cause of clinical death. Research hotspots and difficulties in severe diseases. Therefore, the research on the mechanism of RVI-ALI and the development of therapeutic drugs have always been hot issues in the forefront of this discipline. Viral ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P31/16A61P11/00
CPCA61K9/10A61K9/1652A61K9/2059A61K9/2068A61K9/4866A61K35/413A61K36/185A61K36/233A61K36/237A61K36/238A61K36/284A61K36/286A61K36/355A61K36/53A61K36/538A61K36/634A61K36/736A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 刘小虹赖小平张奉学张伟刘建博李耿陈创荣黄慧婷
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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