Aryl-aryl, aryl-alkyl, alkyl-alkyl asymmetric persulfide compound and synthesis method thereof

Abstract

The invention discloses a synthesis method of aryl-aryl, aryl-alkyl and alkyl-alkyl asymmetric persulfides as shown in a formula (II) or a formula (IV). According to the synthesis method, with sulfinic acid sodium salt, and halogenated hydrocarbon and Na2S2O3 as reaction materials or Bunte salt as a reaction material instead of the halogenated hydrocarbon and Na2S2O3, the aryl-aryl, aryl-alkyl and alkyl-alkyl asymmetric persulfides are obtained by reaction in the absence of transition metal. The synthesis method has the advantages that the reaction is efficient; the yield is high; a vulcanizing reagent is cheap, easily available, stable, and free of pungent smell; no strong acid or alkali or extra oxidizing or reducing agent is added in reaction; the condition is relatively mild; and no transition metal is used as a catalyst in the reaction, and therefore the method is economical, practical and friendly to the environment; a reaction substrate is easy to prepare; the reaction efficiency is high after the reaction is amplified, and therefore, the synthesis method has a wide application prospect and practical value.

Description

technical field

[0001] The invention belongs to the technical field of organic compound technology application, and specifically relates to a class of aryl-aryl, aryl-alkyl, and alkyl-alkyl asymmetric persulfur compounds and an efficient and convenient synthesis method thereof. Background technique

[0002] Organic compounds containing persulfur structures are widely found in biological structures and functional molecules. For example, vegetables such as garlic and onions, and marine organisms such as sea squirts contain persulfur organic compounds, and persulfur structures are found in human and animal peptides It plays an important role in the formation of primary and tertiary structures. Organic compounds containing persulfur are widely used in the synthesis of medicine, polymer materials, pesticides, flavors and flavors, and food additives. Compounds containing persulfur structures are used in the field of medicine. For example, the broad-spectrum antibacterial drug All...

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