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Synthesis technology of novel cosmetic antibacterial agent (ethylhexylglycerin)

A technology of octyloxyglycerol and synthesis process, applied in the field of pharmaceutical synthesis, can solve the problems of harsh reaction conditions, low product quality and high cost, and achieve the effects of short synthesis route, high quality and low cost

Inactive Publication Date: 2015-03-11
PINGHU UCON PHARMA R&D
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AI Technical Summary

Problems solved by technology

[0007] The present invention aims to solve the problems of severe reaction conditions, low product quality, low yield and high cost in the existing synthetic technology of octyloxyglycerol

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  • Synthesis technology of novel cosmetic antibacterial agent (ethylhexylglycerin)

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with specific examples.

[0021] Reaction equation of the present invention is:

[0022]

[0023] Synthetic technique of the present invention comprises the following steps at least:

[0024] Step 1: Condensation Reaction

[0025] In a 50-liter circulating cooling jacket reactor, add 8.8 kg of iso-octanol and cool to 10°C. Add 4.4 kg of solid sodium hydroxide and 0.66 kg of tetrabutylammonium bromide, and stir for half an hour. The temperature is controlled at 10°C, and 7.5 kg of epichlorohydrin is slowly added dropwise for about 2-3 hours. After the dropwise addition, keep the temperature below 20 degrees for 12-15 hours.

[0026] Treatment: 1) Add 25 kg of tap water and stir for 15 minutes; 2) Stand for stratification to obtain 12 kg of the product with a yield of 95%. Clear liquid.

[0027] Step 2: Ring opening reaction

[0028] In a 20-liter oil heating reactor, add 12...

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Abstract

The invention discloses a synthesis technology of a novel cosmetic antibacterial agent (ethylhexylglycerin), which is suitable for industrial production. The synthesis technology at least comprises the following steps: step one, carrying out condensation reactions: mixing isooctanol and alkali, adding a phase transferring agent, dropwise adding epoxy chloropropane to carry out reactions in a cooling condition, washing, and layering to obtain an intermediate (1); step two, performing ring-opening reactions: mixing the intermediate (1) with a ring-opening agent, heating to carry out reactions, washing, and layering to obtain a coarse product (2); step three, refining: making the coarse product (2) go through a rectifying column to carry out separation to obtain qualified product (ethylhexylglycerin). The provided synthesis technology has the characteristics of short synthesis route, low cost, high yield, and high product quality.

Description

technical field [0001] The invention relates to a synthesis process of a novel cosmetic antibacterial agent octyloxyglycerin (Ethylhexyl glycerin), which belongs to the field of drug synthesis. Background technique [0002] Ethylhexyl glycerin is a kind of glycerin, its chemical name is 3-[2-(ethylhexyl)oxy]-1,2-propanediol (3-[2-(Ethylhexyl)oxyl]-1, 2-propandiol), its structural formula is: [0003] [0004] Capryloxyglycerin is a new type of antibacterial agent in cosmetics. This ingredient has a skin-active disinfectant effect. Its synergistic effect is better than that of the previous classic formula, and it will not cause excessive skin irritation to every user. . Its good effect makes sure. [0005] At present, the synthesis process reports of octyloxyglycerin generally have the disadvantages of harsh reaction conditions, low product quality, low yield, high cost and difficult production. Contents of the invention [0006] The purpose of the present in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/13C07C41/26C07C41/42
CPCC07C41/26C07C41/42C07D301/28C07C43/13
Inventor 忻华钟全发史黎辉
Owner PINGHU UCON PHARMA R&D
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