Three-dimensional patch used for nerve regeneration and dura mater repairing

A nerve regeneration and three -dimensional technology, which is used in the field of three -dimensional supplement, can solve problems such as acid poisoning and other problems

Inactive Publication Date: 2015-03-18
冯淑芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation of bacterial cellulose into acidic substances, long-term accumulation will lead to acidosis

Method used

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  • Three-dimensional patch used for nerve regeneration and dura mater repairing
  • Three-dimensional patch used for nerve regeneration and dura mater repairing
  • Three-dimensional patch used for nerve regeneration and dura mater repairing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Such as figure 1 Shown is a three-dimensional patch for nerve regeneration and dura mater prepared in Example 1 of the present invention. The inner layer (support layer) is made of a material with high Young's modulus, high tensile strength and excellent shape maintenance ability. It is woven from regenerated bacterial cellulose; the supporting layer of a three-dimensional patch with a size of 8cm×8cm×0.1cm is woven; the middle layer is coated with an antibacterial enhanced chitosan film with a deacetylation degree of 75% and a molecular weight of 2 million; The outer layer is composed of cross-linked modified sodium hyaluronate with anti-adhesion, extremely strong water holding capacity and water permeability.

[0022] The breaking strength of the patch is 500CN, the breaking elongation is 30%, the knotting breaking strength is 400CN, and the knotting breaking elongation is 20%.

Embodiment 2

[0024] Such as figure 1 Shown is a three-dimensional patch for nerve regeneration and dura mater prepared by the present invention, the support layer is woven from regenerated bacterial cellulose with high Young's modulus, high tensile strength and excellent shape maintenance ability into; weaving the supporting layer of a three-dimensional patch with a size of 15cm×4cm×0.5cm; the middle layer has an antibacterial enhanced deacetylation degree of 95%, and a molecular weight of 1.5 million chitosan; the outer layer is composed of anti-adhesion, extremely It is composed of cross-linked sodium hyaluronate with strong water holding capacity and water permeability.

[0025] The breaking strength of patch is 700CN, and the breaking elongation is 10%, and the knotting breaking strength is 600CN, and the knotting breaking elongation is 10%.

Embodiment 3

[0027] 1. A manufacturing process of a three-dimensional patch for nerve regeneration and dura mater repair: weaving of regenerated bacterial cellulose scaffolds, tissue structure of regenerated bacterial cellulose, and fabric weaving process parameters

[0028] Warp knitting is a kind of knitting method, which uses one or several groups of yarns arranged in parallel to form a knitted fabric at the same time on all the working needles of the warp feeding knitting machine. From the analysis of the physical and mechanical performance requirements of the repair net, the structure of the warp-knitted structure must have several key performance indicators such as sufficient strength, sufficient porosity, and appropriate stiffness.

[0029]

[0030] 2. Process parameters for heat setting of a three-dimensional patch for nerve regeneration and dura mater repair

[0031] The heat setting process will cause changes in the supramolecular structure and morphological structure of the f...

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Abstract

The invention aims to provide a three-dimensional patch used for nerve regeneration and dura mater repairing. A supporting layer is composed of regenerated-base bacterial cellulose being high in Young modulus, being high in tensile strength and being excellent in shape maintaining capability in a knitting manner. A middle layer is composed of anti-microbial-enhanced chitosan membrane. An outer layer is composed of crosslinked sodium hyaluronate being antiblocking, being strong in water binding capacity and being water-permeable and breathable. In addition, the bacterial cellulose is excellent in water binding capacity and the water-permeable and breathable performance and contains internally not conventional circular pores but microchannels in different sizes and large pores so that neutrophil in body can pass through the pores of a repairing net and bacteria being liable to cause infection can be phagocytosed. The three-dimensional patch is beneficial to healing of injury parts without causing infection in the injury parts. The three-dimensional patch is free of reoperation for being taken out since the three-dimensional patch is degradable fiber so that pains in patients can be reduced.

Description

technical field [0001] The patent of the present invention relates to a three-dimensional patch for nerve regeneration and dura mater repair, in particular to the application of the nerve and dura mater patch fabric prepared by tissue engineering technology in the treatment of medical non-supporting tissue and dura mater. Background technique [0002] Cellulose is an attractive natural biopolymer material whose fibrous structure is morphologically identical to the collagen fibers that make up the nerve head. Its interconnected microstructure scaffold has high porosity and is ideal for nerve regeneration and dura mater repair. The structural characteristics of nanofibers are similar to those of the extracellular matrix of tissues. They have extremely high specific surface area, are more conducive to cell adhesion and growth, have better cell adhesion ability and cell activity, and can act on tissue engineering nerve materials. Bacterial cellulose has excellent shape retentio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/20B32B23/04
Inventor 冯淑芹
Owner 冯淑芹
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