A kind of new salvianolic acid compound t, its preparation method and application
A technology of salvianolic acid and mixture, applied in the field of new salvianolic acid compounds, can solve problems such as compounds and pharmacological effects that have not yet been reported and the like
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[0095] The preparation method of the tablet is generally as follows: the salvianolic acid T of the present invention is compressed or molded together with one or more pharmaceutically acceptable auxiliary materials.
[0096] The salvianolic acid T of the present invention can also be made into oral liquid preparations, such as aqueous or oily suspensions, solutions, emulsions, syrups and the like. The salvianolic acid T of the present invention can also be a dry product, which is mixed with water or other suitable carriers before use. Such liquid formulations may contain conventional additives and may include suspending agents such as sorbitol syrup, methylcellulose, glucose / syrup, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminum stearate gel or Hydrogenated edible fats; emulsifiers such as lecithin, sorbitan monooleate, or acacia; non-aqueous carriers (which can include edible oils) such as almond oil, fractionated coconut oil, oily esters, propylene glycol, o...
preparation example 1
[0128] Preparation Example 1 Preparation of salvianolic acid T, (S)-salvianolic acid T and (R)-salvianolic acid T
[0129] Take Danshen decoction pieces, put them in a traditional Chinese medicine decocting device, add a 0.3% (w / v) sodium bicarbonate aqueous solution that is 6 times the mass of the Danshen decoction pieces, decoct for 2.5 hours, and filter; the filtrate is concentrated to a relative density of 1.22 (80°C) water extract.
[0130] Add 95% (v / v) ethanol to the above extract for alcohol precipitation until the alcohol content is 60% (v / v) (25°C), and let stand for 24h; take the supernatant and concentrate under reduced pressure to a relative density of 1.32 (60°C). ) of the alcohol immersion cream.
[0131] The above-mentioned alcohol immersion paste was dissolved in water, passed through AB-8 macroporous adsorption resin, rinsed with an aqueous hydrochloric acid solution of pH=3.0 until the eluent was almost colorless, and then, 95% (v / v) ethanol with 5 times th...
preparation example 2
[0141] Preparation example 2 Preparation of salvianolic acid T, (S)-salvianolic acid T and (R)-salvianolic acid T
[0142] Take Danshen and Panax notoginseng pieces, put them in a traditional Chinese medicine decocting device, add 0.45% (w / v) sodium bicarbonate aqueous solution four times the volume of Danshen and Panax notoginseng pieces, decoct for 2 hours, and filter; the filtrate is concentrated to a relative density of 1.25 (80°C) water extract.
[0143] Add 95% (v / v) ethanol to the above water-extracted extract for alcohol precipitation to 65% (v / v) (25°C), and let stand for 12h; take the supernatant and concentrate under reduced pressure to a relative density of 1.28 (60°C). ) of the alcohol immersion cream.
[0144] The above-mentioned alcohol immersion paste was dissolved in water, passed through AB-8 macroporous adsorption resin, washed with an aqueous hydrochloric acid solution with pH=2.5 until almost colorless, and then eluted with 95% (v / v) ethanol with 4 times ...
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