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Medicinal effervescent tablet and preparation method thereof

A technology for effervescent tablets and medicines, applied in the field of medicine effervescent tablets and their preparation, can solve the problems of low environmental humidity, unfavorable storage, easy occurrence of sticking and punching, etc., and achieve the effects of reducing production costs and reducing environmental humidity requirements.

Active Publication Date: 2015-03-25
峨眉山通惠制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong hygroscopicity as the auxiliary material of the effervescent agent, the phenomenon of sticking and punching is easy to occur in the process of tablet pressing, so the production environment requirements are relatively strict, and a very low ambient humidity (relative humidity <30%) needs to be maintained. )
Moreover, packaging materials with good moisture barrier performance are required in the packaging process, but even in this way, the phenomenon of gas expansion caused by the reaction of acid and alkali moisture absorption is prone to occur during the storage process, which is not conducive to preservation and will also affect the efficacy of the drug.

Method used

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  • Medicinal effervescent tablet and preparation method thereof
  • Medicinal effervescent tablet and preparation method thereof
  • Medicinal effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation method of fudosteine ​​effervescent tablet is as follows:

[0050] (A) In terms of parts by mass, 1 part of carbon dioxide source and 2 parts of filler are pulverized for later use, and 0.2 part of adhesive is mixed with 1 part of wetting agent to prepare a solute with a mass percentage concentration of 1-20%. Adhesive solution ready for use;

[0051] (B) After mixing 1 part of fudosteine, 1 part of organic acid, 0.1 part of disintegrant and 0.1 part of sweetener, it is crushed, passed through a 80-100 mesh sieve, mixed with a binder solution, and sieved Granulating, drying, and sieving to obtain the first granular mixture;

[0052] (C) After melting 0.5 part of the release agent, add 1 part of the pulverized carbon dioxide source, after stirring, cooling, pulverizing and passing through a 80-100 mesh sieve, add the filler for mixing and stirring, and then mix with the remaining binder solution Finally, sieve and granulate, dry, and then sieve to obtai...

Embodiment 2

[0056] The preparation method of acetylcysteine ​​effervescent tablet is as follows:

[0057] (A) In terms of parts by mass, 15 parts of sodium bicarbonate and 10 parts of mannitol are first pulverized for later use, and 0.6 parts of povidone K30 is mixed with 5 parts of water to prepare a solute with a mass percentage concentration of 1-20%. Adhesive solution ready for use;

[0058] (B) After mixing 12 parts of acetylcysteine, 12 parts of citric acid, 0.5 parts of low-substituted hydroxypropyl cellulose and 0.3 parts of sucralose, they are crushed, passed through an 80-mesh sieve, and mixed with a binder solution 1. Sieve and granulate, dry at 50-60°C, and then sieve to obtain the first granule mixture with a mesh size above 18 mesh;

[0059] (C) After melting 10 parts of polyethylene glycol 4000 at 60-80°C, add 15 parts of pulverized sodium bicarbonate, after stirring, cooling, pulverizing and passing through an 80-mesh sieve, add mannitol for mixing and stirring, and then ...

Embodiment 3

[0066] The preparation method of vitamin C effervescent tablet is as follows:

[0067] (A) In terms of parts by mass, 10 parts of a mixture of potassium bicarbonate and sodium carbonate, 8 parts of a mixture of mannitol and lactose are pulverized for later use, and 0.4 parts of povidone K30 is mixed with 3 parts of a mixture of ethanol and water to prepare The mass percent concentration of solute is 1-20% binder solution for subsequent use;

[0068] (B) After mixing 10 parts of vitamin C, 10 parts of a mixture of malic acid and tartaric acid, 0.3 parts of cross-linked polyvinylpyrrolidone, and 0.2 parts of aspartame, they are crushed, passed through an 80-mesh sieve, and mixed with a binder solution 1. Sieve and granulate, dry at 50-60°C, and then sieve to obtain the first granule mixture with a mesh size above 18 mesh;

[0069] (C) Melt 8 parts of polyethylene glycol 6000 at 60-80°C, add 15 parts of the mixture of crushed potassium bicarbonate and sodium carbonate, and add m...

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Abstract

The invention provides a medicinal effervescent tablet and a preparation method thereof. The preparation method comprises the following steps: (A) grinding a carbon dioxide source and filler for later use, and mixing an adhesive and a wetting agent to prepare an adhesive solution for later use; (B) mixing main components, organic acid, a disintegrating agent and a sweetening agent, and treating to obtain a first particulate mixture; (C) melting a parting agent, adding the molten parting agent into the carbon dioxide source, treating, adding the filter for stirring, mixing with remained adhesive solution, and treating to obtain a second particulate mixture; (D) grinding 1-2 percent of the total mass of the second particulate mixture into powder, adding essence for mixing, and dispersing to the remained second particulate mixture to form a third particulate mixture; and (E) tabletting the first particulate mixture and the third particulate mixture, packaging and detecting to obtain a finished product. The medicinal effervescent tablet is easy to preserve, and has the advantages of no sack expansion or sticky tablet in the storing process.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a drug effervescent tablet and a preparation method thereof. Background technique [0002] Effervescent tablet is a novel tablet developed and applied abroad in recent years. It differs from ordinary tablets in that it also contains an effervescent disintegrant. When the effervescent tablet is put into drinking water, under the action of the effervescent disintegrant, a large number of bubbles (carbon dioxide) will be generated immediately, making the The tablet disintegrates and melts quickly, and sometimes the air bubbles generated by the disintegration will make the tablet roll up and down in the water, accelerating its disintegration and melting. The carbon dioxide produced when the tablet disintegrates is partially dissolved in the drinking water, so that the drinking water has an aesthetic feeling like soda pop when it is taken into the mouth. [0003] Effervescent tablets have th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/375A61K31/198A61K47/34
Inventor 唐雪枫陈果王晓玲张寒煦王风顺梁仁兴袁波潘文洪
Owner 峨眉山通惠制药有限公司
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