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Pharmaceutical composition for treating inflammatory demyelinating diseases of central nervous system and application of combined administration thereof

A demyelinating disease, central nervous system technology, applied in nervous system diseases, drug combinations, allergic diseases, etc., can solve the problems of lack of specific drug treatment and incomplete elucidation of the pathogenesis.

Active Publication Date: 2017-06-20
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Inflammatory demyelinating diseases of the central nervous system are a very common type of central nervous system autoimmune diseases mediated by T cells, mainly including multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), sub Acute neuromyelitis optica (SMON), concentric sclerosis, central allergic diseases induced by various reasons (such as after infection with various biological pathogens, after vaccination, heterosexual protein allergy, and drug or chemical allergic reaction) ( Such as acute demyelinating leukoencephalopathy and acute demyelinating myelitis), the pathogenesis has not been fully elucidated, and there is currently a lack of specific drug treatment

Method used

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  • Pharmaceutical composition for treating inflammatory demyelinating diseases of central nervous system and application of combined administration thereof
  • Pharmaceutical composition for treating inflammatory demyelinating diseases of central nervous system and application of combined administration thereof
  • Pharmaceutical composition for treating inflammatory demyelinating diseases of central nervous system and application of combined administration thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1. Study on the Mechanism of SCH in Treating Central Nervous System Inflammatory Demyelinating Diseases

[0067] 1. Making of EAE model

[0068] Of 48 C57BL / 6 mice, 42 of them were randomly selected, and each mouse was anesthetized with 0.5% pentobarbital (0.27ml) intraperitoneally, and then intradermally injected with antigen at four points at the base of the tail, both sides of the abdomen, and the neck. Emulsion (mixed with myelin oligodendrocyte glycoprotein (MOG) and complete Freund's adjuvant), inject 0.05ml at each point, 0.2ml in total, and then intraperitoneally inject pertussis toxin immediately and 48 hours later. , PT) 500ng to induce an immune response to create a classic EAE model.

[0069] 2. Animal Grouping and Drug Intervention

[0070]Six mice that were not injected with MOG antigen emulsion were used as the normal control group; 42 EAE model mice that were injected with MOG antigen emulsion were randomly divided into DMSO control group, incu...

Embodiment 2

[0105] Example 2. Combined use of 2-BFI and SCH in the treatment of central nervous system inflammatory demyelinating diseases

[0106] 1. Making of EAE model

[0107] There were 64 C57BL / 6 mice, and each mouse was anesthetized with 0.5% pentobarbital 0.27ml intraperitoneally, and then injected MOG antigen emulsion intradermally at the base of the tail, both sides of the abdomen, and the neck (injection at each point) 0.05ml, 0.2ml in total). Immediately and 48 hours after the injection, 500 ng of pertussis toxin (PT) was injected intraperitoneally, respectively, to induce an immune response, and to create a classic EAE model.

[0108] 2. Animal Grouping and Drug Intervention

[0109] The EAE model mice injected with MOG antigen emulsion and immunized were randomly divided into 6 groups, and SCH was dissolved in 5% DMSO as a vehicle to make a 0.02% SCH solution for later use; 2-FBI was dissolved in 0.9% normal saline to make a concentration of 0.2 %2-BFI solution for later ...

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Abstract

The invention provides a pharmaceutical composition for treating central nervous system inflammatory demyelinating diseases. The pharmaceutical composition comprises 2-(2-benzofuranyl)-2-imidazoline or a pharmaceutically acceptable salt, a hydrate and a solvate thereof as an active ingredient, and 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-(4, 3-e)-1, 2, 4-triazolo (1, 5-c) pyrimidine or a pharmaceutically acceptable salt, a hydrate and a solvate thereof. The invention further provides a combination containing two medicaments and also provides application of the pharmaceutical composition and the pharmaceutical combination in combined treatment of the central nervous system inflammatory demyelinating diseases, and the synergistic treatment effect is obtained.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating central nervous system inflammatory demyelinating diseases. Background technique [0002] Inflammatory demyelinating diseases of the central nervous system are a very common type of central nervous system autoimmune diseases mediated by T cells, mainly including multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), sub Acute neuromyelitis optica (SMON), concentric sclerosis, central allergic diseases induced by various reasons (such as after infection with various biological pathogens, after vaccination, heterosexual protein allergy, and drug or chemical allergic reaction) ( Such as acute demyelinating leukoencephalopathy and acute demyelinating myelitis), the pathogenesis has not been fully elucidated, and there is currently a lack of specific drug treatment. Experimental autoimmune encephalomyelitis (EAE) animal model is curren...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K31/4178A61P25/00A61P25/02A61P37/08
CPCA61K31/4178A61K31/519A61K2300/00
Inventor 郑荣远侯圣陶殷为勇张元涛郑浏璞王志强徐惠琴
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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