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Improved production process of cefixime tablets

A cefixime and process technology, applied in the field of cefixime tablets and production process, can solve problems such as lack of fluidity, compressibility and lubricity, affect production progress, and easy sticking, etc., to achieve excellent fluidity, Fast release of drugs and the effect of solving the problem of sticking and punching

Inactive Publication Date: 2015-04-08
TIANJIN PHARMA GROUP GENCOM PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the drug powder of this product does not have good fluidity, compressibility and lubricity, it is easy to stick and clog, which seriously affects the production progress

Method used

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  • Improved production process of cefixime tablets
  • Improved production process of cefixime tablets
  • Improved production process of cefixime tablets

Examples

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Effect test

Embodiment Construction

[0011] The following application examples will further illustrate it, and the simple replacements or improvements made by those skilled in the art to the present invention all belong to the technical solutions protected by the present invention.

[0012] 1. prepare cefixime tablet, take by weighing the cefixime 100mg of prescription quantity, spray granule lactose 60mg, microcrystalline cellulose 50mg, cross 100 mesh sieves; Take by weighing again the croscarmellose sodium 15mg of prescription quantity, Magnesium stearate 2 mg, passed through a 60-mesh sieve; the above main ingredients and auxiliary materials were placed in a dry granulator, dry granulated, and compressed into tablets to obtain Cefixime Tablets A1. At the same time, the same method and dosage were adopted, and the spray granule lactose was replaced with 200 mesh lactose of the prescription to prepare the Cefixime tablet A2 used in the comparative test.

[0013] 1. First, Cefixime Tablets A2 was used to carry o...

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Abstract

The invention provides an improved production process of cefixime tablets. The problem on sticking of cefixime tablets can be solved effectively by replacing the frequently-used lactose with spray particle lactose with excellent flowability and compressibility, wherein the spray particle lactose is lactose monohydrate which is prepared by spray drying. Multiple research tests show that a significant effect of resisting the sticking of cefixime tablets can be achieved by replacing the 200-mesh lactose in a formula with the spray particle lactose. The cefixime tablets formed by pressing are smooth and attractive in surface and can release medicines rapidly, and the sticking defect rate of the cefixime tablets is reduced to 0.0% from 25.9%. The improved production process of the cefixime tables is simple and convenient. By adopting the improved production process of the cefixime tables, the problems on sticking of cefixime tablets can be solved effectively, and the time and labor utilization rate can be increased.

Description

technical field [0001] The invention relates to a cefixime tablet and a production process, belonging to the technical field of medicine. Background technique [0002] Cefixime (cefixime) is an oral third-generation cephalosporin antibiotic, developed by Japan Fujisawa Co., Ltd., and first listed in Japan in 1987 by Japan Fujisawa Pharmaceutical Co., Ltd., with a trade name of Cefspan. Cefixime has the following characteristics: broad antibacterial spectrum, it has spectrum antibacterial effect on Gram-positive bacteria and negative bacteria; long half-life, can be taken only once or twice a day, easy to use; less cross-resistance It is extremely stable to the β-lactamase produced by various bacteria, and can effectively inhibit or kill Serratia, Enterobacter, Proteus, etc. that are clinically resistant to other cephalosporin antibiotics; the dose is small, and the body is widely distributed. High curative effect, low cost of use, strong market competitiveness; good permeab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/26A61K31/546A61P31/04
Inventor 赵洪霞廖飞魏晨曦
Owner TIANJIN PHARMA GROUP GENCOM PHARMA
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