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Magnesium phosphate cement as well as preparation method and application thereof

A technology of magnesium phosphate bone cement and phosphate, which is applied in the field of medical biological materials, can solve the problems of fast hydration reaction speed, decreased human function, obvious side effects, etc., and achieves reduction of hydration reaction speed, lower hydration temperature, and simple operation. Effect

Active Publication Date: 2015-04-08
QINGHAI INST OF SALT LAKES OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Years of research have shown that MPC has good biocompatibility and biodegradability, and is an ideal material for repairing bone defects. have not received enough attention and research
For example, under adiabatic conditions, the maximum hydration temperature of MPC reaches nearly 70°C, and these problems have not been well resolved.
However, the magnesium phosphate bone cement involved in this patent uses boron-containing magnesia, a by-product in the process of extracting lithium from salt lakes, as a raw material, and is calcined at high temperature to obtain medical grade sintered magnesia. The above method introduces some inorganic ions, which will interfere with the body fluid environment of the human body, leading to a decline in human body function and even human poisoning, with obvious side effects

Method used

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  • Magnesium phosphate cement as well as preparation method and application thereof
  • Magnesium phosphate cement as well as preparation method and application thereof
  • Magnesium phosphate cement as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] figure 1 It is a flowchart of the preparation method of the magnesium phosphate bone cement according to the embodiment of the present invention.

[0025] refer to figure 1 , the preparation method of the magnesium phosphate bone cement according to the embodiment of the present invention comprises steps:

[0026] Step 110: Calcining boron-containing magnesia, a by-product of lithium extraction from salt lake, at 1000° C. for 3 hours to produce medical grade sintered magnesia. Wherein, the sintered magnesia of this embodiment refers to: the magnesia slag rich in magnesia (that is, the boron-containing magnesia by-product of lithium extraction from salt lake in this embodiment) is calcined at a high temperature, and all or part of the magnesia components therein are transformed into For magnesium oxide crystals. The magnesium oxide crystal has certain activity, and the presence of the active magnesium oxide helps the magnesium phosphate bone cement to form a skeleton ...

Embodiment 2

[0041] In the description of Embodiment 2, the similarities with Embodiment 1 will not be repeated here, and only the differences with Embodiment 1 will be described. The difference between Example 2 and Example 1 is that: in step 110, sintered magnesia is obtained by calcining at a calcination temperature of 800° C. for 3 h; in step 120, the amount of sintered magnesia is 200 parts, and ammonium dihydrogen phosphate is 100 parts were ball milled for 30 minutes to obtain magnesium phosphate bone cement powder with a particle size of about 10 μm. The amount of composite retarder is 20 parts, which is 10% of the amount of sintered magnesia, wherein the mass fractions of glucose, sucrose, citric acid and chloride in each composite retarder are 25%, 25%, and 10% respectively , 40%; In the present embodiment, the chloride is sodium chloride, but the present invention is not limited thereto, other chlorides with similar properties can be used.

[0042] The mass fraction of each ion...

Embodiment 3

[0052] In the description of Embodiment 3, the similarities with Embodiment 1 will not be repeated here, and only the differences with Embodiment 1 will be described. The difference between Example 3 and Example 1 is that: in step 110, sintered magnesia is obtained by calcining at a calcination temperature of 1400° C. for 6 h; in step 220, the amount of sintered magnesia is 400 parts, and sodium dihydrogen phosphate is 100 parts, ball milled for 10 minutes to obtain magnesium phosphate bone cement powder with a particle size of about 70 μm; the amount of composite retarder is 60 parts, which is 15% of the amount of sintered magnesium oxide, wherein, in each part of composite retarder, sucrose and chlorine The mass fraction of sodium chloride is 50%.

[0053] The mass fractions of the ions in boron-containing magnesium oxide, a by-product of lithium extraction from salt lakes, were analyzed before and after calcination, and the results are shown in Table 6.

[0054] Table 6

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Abstract

The invention relates to magnesium phosphate cement as well as a preparation method thereof. The magnesium phosphate cement at least comprises the following components in parts by weight: 100-400 parts of sintered magnesia, 100 parts of phosphate and 5-80 parts of a compound retarder, wherein the sintered magnesia is a calcined product of a salt lake-based lithium by-product magnesium oxide; and the compound retarder comprises a mixture of at least two of glucose, sucrose and chloride, and can also comprise citric acid. The preparation method of the magnesium phosphate cement comprises the following steps: mixing the sintered magnesia and the phosphate with the compound retarder, and carrying out ball-milling to obtain the magnesium phosphate cement. The compound retarder can be applied to a bone repair surgery. According to the magnesium phosphate cement disclosed by the invention, the hydration reaction rate and the hydration temperature are reduced; meanwhile, the strength of the magnesium phosphate cement meets the requirements; the operation is simple; and the cost is relatively low.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a magnesium phosphate bone cement and its preparation method and application. Background technique [0002] Magnesia-Phosphate Cement (MPC) is mainly prepared by sintered magnesia, phosphate and retarder in a certain proportion, and has the characteristics of fast setting and high early strength. As early as 1945, Brookhaven Laboratories used MPC as a quick repair material for buildings. As a type of inorganic adhesive, MPC is similar to calcium phosphate bone cement (CPC), which can solidify itself under the physiological environment of the human body. The hydration product is a phosphate biomineral, which has good biocompatibility. Years of research have shown that MPC has good biocompatibility and biodegradability, and is an ideal material for repairing bone defects. It has not been paid enough attention and research by people. For example, under ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B28/34C04B24/10C04B22/12A61L27/12C04B103/22
Inventor 董金美肖学英余红发文静李颖常成功郑卫新
Owner QINGHAI INST OF SALT LAKES OF CHINESE ACAD OF SCI
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