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Application of buddle jasaponin IV in preparation of medicine for treating non-alcoholic fatty liver disease and insulin resistance diseases

An insulin resistance, non-alcoholic technology, applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problem of less research on the pharmacological activity of astragaloside IV

Inactive Publication Date: 2015-04-22
广西壮族自冶区中国科学院广西植物研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, there are few studies on the pharmacological activity of Buendeoside IV

Method used

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  • Application of buddle jasaponin IV in preparation of medicine for treating non-alcoholic fatty liver disease and insulin resistance diseases
  • Application of buddle jasaponin IV in preparation of medicine for treating non-alcoholic fatty liver disease and insulin resistance diseases
  • Application of buddle jasaponin IV in preparation of medicine for treating non-alcoholic fatty liver disease and insulin resistance diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] 1. Establishment of animal models

[0014] Male Kunming mice, SPF grade, weighing 18-22g, were provided by Hunan Slike Jingda Laboratory Animal Co., Ltd. Production license number: SCXK (Xiang) 2009-0004.

[0015] The mice were randomly divided into two groups, the control group mice (10 mice) were fed with common feed, and the other mice (45 mice) were fed with high-fat feed (66.9% common feed powder, 10% lard, 10% milk powder, 10% sucrose, 2% cholesterol, 1% cholate, 0.1% propylthiouracil), food and water ad libitum. After 8 weeks of continuous feeding, compared with the control group, the modeled liver index was significantly increased, and liver cell steatosis was observed in the pathological section of liver tissue.

[0016] 2. Grouping and dosing

[0017] 40 model mice were randomly divided into 4 groups, 10 mice in each group, which were model group, simvastatin positive control group (dose concentration of 5 mg / kg, dissolved in 5‰ CMC aqueous solution), simva...

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Abstract

The invention discloses an application of buddle jasaponin IV in preparation of medicine for treating the non-alcoholic fatty liver disease and the insulin resistance diseases. The tests show that in the application process, the buddle jasaponin IV has a remarkable effect of improving the non-alcoholic fatty liver, the mechanism of the buddle jasaponin IV is related with an anti-oxidative stress effect and the improvement on the insulin resistance, and therefore the buddle jasaponin IV can be used for treating the other diseases related with insulin resistance.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to the medicinal use of aspicoside IV, in particular to the application of aspicoside IV in the preparation of medicines for treating non-alcoholic fatty liver and insulin resistance. Background technique [0002] With the continuous improvement of people's material life and changes in dietary structure, the incidence of non-alcoholic fatty liver disease (NAFLD) has also increased year by year, and has become a common liver disease second only to viral hepatitis. At present, the pathogenesis of NAFLD is very complex and has not been fully studied so far. It is generally believed that the occurrence and development of NAFLD disease can be summarized as a molecular mechanism model of "two hits" or "multiple hits". At the same time, the treatment drugs are not perfect, and the clinical practice is still in the exploratory stage. Therefore, it is of great significance to study the drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16A61P5/50
CPCA61K31/7048
Inventor 陈月圆杨子明李典鹏陈洁晶黄永林颜小捷卢凤来
Owner 广西壮族自冶区中国科学院广西植物研究所
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