Haloperidol composition freeze drying tablet and preparation method thereof
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The technology of haloperidol and composition is applied in the field of haloperidol composition freeze-dried tablet and preparation thereof, and achieves the effects of ensuring curative effect and safety, large dissolution rate and high bioavailability
Inactive Publication Date: 2015-04-29
HAINAN WEI KANG PHARMA QIANSHAN
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[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of haloperidol freeze-dried tablets by freeze-drying process
Method used
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Embodiment 1
[0026]
[0027] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.
[0028] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.
[0029] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.
[0030] D. Weigh 2 g of haloperidol, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.
[0031] E. After measuring the content of haloperidol in the medicinal solution, ...
Embodiment 2
[0034]
[0035] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7, then heat to 72°C and keep for 120 minutes to make 13% (W / V ) of cornstarch solution.
[0036] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.
[0037] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.
[0038] D. Weigh 2 grams of haloperidol (calculated as 1000 tablets), add 1L of corn-sucrose solution, and stir for 30 minutes.
[0039] E. After measuring the content of haloperidol ...
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Abstract
The invention provides a haloperidol composition freeze drying tablet and a preparation method thereof, and relates to the technical field of medicines and medicine production. The haloperidol composition freeze drying tablet comprises haloperidol, starch and cane sugar, wherein the starch and the cane sugar are used as accessories, and heating processing is performed on normal corn starch, so that the adhesive effect and the disintegration effect of the starch in tablets are improved, and the formability of the tablets is improved. The haloperidol composition freeze drying tablet only needs two kinds of accessories which are the starch and the cane sugar. The haloperidol composition freeze drying tablet adopts a freeze drying technology that the temperature is dropped twice and raised twice, and the temperature is dropped twice and raised twice, so that the tablet can have a better formability, the dissolution rate of the tablets is improved, and the bioavailability of the tablets is improved. The tablet overcomes the disadvantages of a normal haloperidol tablet and reduces the type and the dosage of the accessories in the haloperidol tablet, the dissolution rate of the tablet is large, the bioavailability of the tablet is high, and the curative effect and the safety of the clinical medication are ensured.
Description
technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a haloperidol composition freeze-dried tablet and a preparation method thereof. Background technique [0002] Haloperidol tablets are used for acute and chronic schizophrenia, mania, and Tourette's syndrome. It is better for controlling agitation, hostility and aggressive behavior. Because this product has less cardiovascular adverse reactions, it can also be used for brain organic mental disorders and senile mental disorders. The main ingredient of this product is haloperidol, and its chemical name is: 1-(4-fluorophenyl)-4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1 - butanone. [0003] [0004] Molecular weight: 375.87 [0005] Ordinary haloperidol tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. According to the quality standard of piperidol tabl...
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