Medicament for treating osteoarticular diseases and preparation method of medicament

A technology for bone and joint diseases and drugs, applied in bone diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of life-threatening, immobility, poor prognosis, etc., and achieve the effect of maintaining normal function and adequate nutrition

Inactive Publication Date: 2015-05-06
郭曙平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the vitality and metabolism of human muscles must also be completed through exercise. If you refuse to exercise because of pain, the joints will be stiff and the muscles will atrophy, unable to move, and you will be bedridden for a long time.
Long-term bed rest will lead to bedsores, blood circulation disorders, and then serious complications such as thrombosis. The prognosis will inevitably become worse and worse, and the result will be a serious threat to life.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Get 2.5Kg of glucosamine sulfate (about 21% of weight percentage), 2.5Kg of chondroitin sulfate (about 21% of weight percentage), 0.02Kg of glucosamine (about 0.17% of weight percentage), add pregel Starch 2Kg (about 17% by weight), microcrystalline cellulose 2Kg (about 17% by weight), sodium carboxymethyl starch 2Kg (about 17% by weight), povidone K30 0.5Kg (about 4.2% by weight), mix homogeneously, dry granulation; add micropowder silica gel 0.1Kg (about 0.1% by weight), magnesium stearate 0.2Kg (about 0.2% by weight), mix Evenly, compress into tablets or fill in capsules to obtain compound glucosamine tablets or capsules for treating bone and joint diseases containing high-efficiency non-addictive analgesic glucosamine.

Embodiment 2

[0023] Take 2.5Kg of glucosamine sulfate, 2.5Kg of chondroitin sulfate, and 0.02Kg of aconitin, add 2Kg of pregelatinized starch, 2Kg of microcrystalline cellulose, 2Kg of carboxymethyl starch sodium, and 0.5Kg of povidone K30, and mix evenly. Dry granulation; add 0.1Kg of micro-powder silica gel and 0.2Kg of magnesium stearate, mix well, press into tablets or fill in capsules, and then obtain the compound glucosamine for treating bone and joint diseases containing the highly effective non-addictive analgesic herbal glucosamine Tablet or capsule.

Embodiment 3

[0025] Take glucosamine sulfate 2.5Kg, chondroitin sulfate 2.5Kg, aconitine 0.02Kg, add pregelatinized starch 2Kg, microcrystalline cellulose 2Kg, carboxymethyl starch sodium 2Kg, povidone K300.5Kg, mix well, Dry granulation; add 0.1Kg of micropowder silica gel and 0.2Kg of magnesium stearate, mix evenly, press into tablets or fill capsules, and obtain the compound formula for treating bone and joint diseases containing the highly effective non-addictive analgesic aconitine Glucosamine tablets or capsules.

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PUM

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Abstract

The invention relates to a medicament for treating osteoarticular diseases and a preparation method of the medicament. The medicament comprises the following components in percentage by weight (W/W): 1%-25% of glucosamine, 1%-25% of chondroitin sulfate and 0.01%-2% of an efficient non-addictive analgesic, wherein the efficient non-addictive analgesic is lappaconitine, bulleyaconitine A or aconine extracted from ranunculaceous aconitum plants. According to the medicament, the defect that an existing preparation cannot be used for relieving pain is overcome; by virtue of the efficient non-addictive analgesic, the nervous impulse transfer of pain is blocked, the activity of injured bone joints can be maintained, and meanwhile, power is provided for the replacement and the expelling of metabolite in cavities of bone joints, so that the metastasis is maintained, the injured bone joint surfaces are repaired, and the normal functions of the bone joints are maintained; by virtue of blood circulation in skeletal muscles, sufficient nutrients are supplied to the muscles, and the amyotrophy is avoided.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine for treating bone and joint diseases and a preparation method thereof. Background technique [0002] Before the present invention was made, the existing medicines for the treatment of osteoarthritis had glucosamine and glucosamine+chondroitin sulfate compound preparations, and the defect that they existed was that they could not relieve pain. However, pain relief plays a very important role in the treatment of bone and joint diseases. [0003] The mechanism is that bone and joint diseases are analyzed from the pathobiochemical perspective of the disease, and it is a slow decline year by year after the biosynthetic response ability reaches its peak. This starting age may have begun to appear after the age of 20. Two very important biochemical substances are involved here, Glucosamine and Chondroitin Sulfate (a basic form of chondroitin). Glucosamine is an amino-containing sugar in the h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P19/02A61P29/00A61K31/7008A61K31/439
Inventor 陈妍施翼麟薛清孙晓晶郭曙平
Owner 郭曙平
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