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Extraction preparation method of palmatine chloride and application thereof to preparation of medicine for preventing and treating colorectal cancer

A technology of palmatine hydrochloride and hydrochloric acid, which is applied in the field of preparation of drugs for the prevention and treatment of colon cancer, can solve the problems of long cycle, cumbersome process, and time-consuming solution recovery, and achieve simple operation, high extraction rate, and low cost Effect

Inactive Publication Date: 2015-05-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dipping and standing time of dilute acid water is long, the efficiency is low, the solution recovery is time-consuming, the process is cumbersome, the cycle is long, and it is not suitable for industrial production.

Method used

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  • Extraction preparation method of palmatine chloride and application thereof to preparation of medicine for preventing and treating colorectal cancer
  • Extraction preparation method of palmatine chloride and application thereof to preparation of medicine for preventing and treating colorectal cancer

Examples

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Effect test

Embodiment 1

[0021] Get 1kg of Gonggong wood medicine powder and add in the extraction container, add 12L of 0.2% acid alcohol (50%) solution, reflux, merge the filtrate, reclaim the solvent, concentrate the medicinal solution, adjust the pH to 10 with alkali, leave standstill, and filter. After the filtrate was concentrated, the pH was adjusted to 2, 15% sodium chloride was added, allowed to stand, and filtered. After drying the precipitate, redissolve with 30 times the volume of alkaline aqueous solution, reflux, adjust the pH of the filtrate to 10, adjust the pH to 2 after the filtrate is concentrated, add 15% sodium chloride, stand still, and filter. Dry the precipitate. The precipitate was redissolved with 20 times the volume of alkaline aqueous solution, refluxed, and filtered. The precipitate was extracted with 95% ethanol under reflux, filtered, and the filtrate was adjusted to pH 2 with hydrochloric acid to obtain a dry precipitate. The content of palmatine hydrochloride was 90.2...

Embodiment 2

[0023] Take 1 kg of coptis powder and add it to the extraction container, add 12L of 0.2% acetic acid alcohol (50%) solution, reflux, combine the extracts, recover the solvent, concentrate the liquid, then adjust the pH to 9 with alkali, let it stand, and filter. After the filtrate was concentrated, the pH was adjusted to 1, 15% sodium chloride was added, allowed to stand, and filtered. After drying the precipitate, redissolve with 30 times the volume of alkaline aqueous solution, reflux, filter, adjust the pH of the filtrate to 9, stand still, filter, adjust the pH to 1 after the filtrate is concentrated, add 15% sodium chloride, stand still, and filter. Dry the precipitate. The precipitate was redissolved with 10 times the volume of alkaline aqueous solution, refluxed once, and filtered. The precipitate was extracted with reflux of 95% ethanol, filtered, and the filtrate was adjusted to pH 2 with hydrochloric acid to obtain a dry precipitate. The content of palmatine hydroc...

Embodiment 3

[0025] Get Phellodendron Phellodendron medicinal powder 1kg and add in the extraction container, add 12L of 0.2% acid alcohol (50%) solution, reflux, combine extract, recover solvent, concentrate medicinal liquid, then adjust pH to 9 with alkali, stand still, filter. After the filtrate was concentrated, the pH was adjusted to 1, 15% sodium chloride was added, allowed to stand, and filtered. After drying the precipitate, redissolve with 30 times the volume of alkaline aqueous solution, reflux, filter, adjust the pH of the filtrate to 9, stand still, filter, adjust the pH to 1 after the filtrate is concentrated, add 15% sodium chloride, stand still, and filter. Dry the precipitate. The precipitate was redissolved with 10 times the volume of alkaline aqueous solution, refluxed once, and filtered. The precipitate was extracted with 95% ethanol under reflux, filtered, and the filtrate was adjusted to pH 2 with hydrochloric acid to obtain a dry precipitate. The content of palmatine...

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Abstract

The invention provides a method for performing extraction preparation on palmatine chloride from traditional Chinese medicines and application of the palmatine chloride to preparation of a medicine for preventing and treating colorectal cancer. According to the preparation method, an acid-alkali system solvent method is adopted, medicinal materials are pulverized and 0.1-2 percent of acid waterborne solvents are added for performing backflow and extraction; the solvents are treated by utilizing the acid-alkali system solvent method after being recycled to obtain palmatine chloride of which the purity is more than 85 percent. The palmatine chloride prepared by using the method has the advantages of high purity, short period and low cost, and is an environmental-friendly preparation method and suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting and preparing palmatine hydrochloride from traditional Chinese medicine by using an acid-base system solvent method and its application in preparing medicines for preventing and treating colon cancer. Background technique [0002] Palmatine hydrochloride (Palmatine) is the original berberine type isoquinoline alkaloid, molecular formula is C 21 h 22 NO 4 , with a molecular weight of 352, no toxic and side effects, a wide range of physiological activities, including antibacterial, analgesic, antihypertensive, immune regulation and other functions, and has a wide range of applications in the field of medicine. [0003] Gongluomu, Coptis chinensis, Cortex Phellodendron, Huangteng, and Three Needles are the medicinal materials recorded in the Chinese Pharmacopoeia 2010 Edition. , boils, carbuncles, dysentery and jaundice hepatitis. Modern pharmacological studies have shown that they all have antibacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03A61K31/4375A61P35/00
CPCC07D455/03A61K31/4375A61K2300/00
Inventor 张春凤
Owner CHINA PHARM UNIV
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