Injection molding anisotropic bone substitute composite material and preparation method thereof

A composite material and injection molding technology, applied in medical science, prosthesis, etc., can solve problems such as limited effects, and achieve the effect of improving tensile properties
CN104623728AActive Publication Date: 2015-05-20SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2015-05-20

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Abstract

The invention relates to an injection molding anisotropic bone substitute composite material and a preparation method thereof. The composite material is compounded by hydroxyapatite (HA) with biological activity and high-density polyethylene (HDPE) with biocompatibility in a vibration injection molding manner. The method comprises the following steps: (1) preparing an HA / HDPE mechanical mixture; (2) preparing an HA / HDPE melt mixture; and (3) carrying out vibration injection molding. According to the injection molding anisotropic bone replacement composite material, dispersion of HA in HDPE matrix is significantly improved; meanwhile, a large number of shish-kebab structures are formed in the HA / HDPE composite material in a vibration injection molding process; an anisotropic bionic structure with a similar natural bone tissue is obtained; the tensile property, the bending property and the impact strength are significantly improved; and the anisotropic bone substitute composite material is relatively suitable for being used as a human weight-bearing bone substitute material.
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Description

technical field

[0001] The invention belongs to the field of biomedical polymer materials, in particular, the invention relates to an injection-molded anisotropic bone replacement composite material and a preparation method thereof. Background technique

[0002] Bone tissue transplantation is a clinical allograft method second only to blood transfusion, and it is also an important treatment option for repairing bone defects. With the increase of average age and the diversification of lifestyle, the number of patients who need bone transplantation is increasing, and the advancement of medical technology makes patients hope to return to normal life through high-quality transplantation. The performance of the material puts forward higher requirements (G.K.Naughton, W.R.Tolbert, T.M.Grillot.Tissue Engineering.1995, 1:211~219.). High-density polyethylene (HDPE) is a biocompatible polymer material that has been approved by the U.S. Food and Drug Administration (FDA) for use in hu...

Claims

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