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Injection molding anisotropic bone substitute composite material and preparation method thereof

A composite material and injection molding technology, applied in medical science, prosthesis, etc., can solve problems such as limited effects, and achieve the effect of improving tensile properties

Active Publication Date: 2015-05-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it can be seen from the above data that although the above method can improve the strength of the HA / HDPE composite material to a certain extent, the effect is limited, only a few MPa

Method used

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  • Injection molding anisotropic bone substitute composite material and preparation method thereof
  • Injection molding anisotropic bone substitute composite material and preparation method thereof
  • Injection molding anisotropic bone substitute composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of pure HDPE extruded pellets: put pure HDPE in a twin-screw extruder to melt and extrude, and the extruder conveys the compression section, and the temperatures of the melting section and the metering section are set to 170°C and 200°C, respectively. 190°C, the speed of the main engine is set at 120 rpm, and the speed of the feeding screw is 4 rpm, then the extruded product is forced to cool and pelletized, and dried at 90°C for 10 hours until the water content is not higher than 0.01% of its own weight;

[0034] (2) Vibration injection molding: Vibration injection molding is performed on the above-mentioned dried extruded pellets. The barrel and nozzle temperatures of the injection molding machine are set at 180°C and 190°C respectively, the temperature of the hot runner is set at 180°C, and the mold temperature is set at 180°C. It is set at 30°C, and the holding pressures of the three stages are set at 0, 25, and 35 MPa respectively.

Embodiment 2

[0036] (1) Preparation of 5wt% HA / HDPE mechanical mixture: 5% HA and 95% HDPE were mechanically mixed with a high mixer for 20 minutes to make them evenly mixed.

[0037] (2) Preparation of 5wt% HA / HDPE melt mixture: the above mixture is placed in a twin-screw extruder for melt extrusion, and the extruder conveys the compression section, and the temperatures of the melting section and the metering section are respectively set to 170°C and 200°C, 190°C, the speed of the main engine is set at 120 rpm, and the speed of the feeding screw is 4 rpm, then the mixture is forced to cool and granulate, and dried under vacuum at 90°C until the water content is not higher than its own weight. 0.01% made extruded material;

[0038] (3) Vibration injection molding: Vibration injection molding is performed on the above dried extruded pellets. The barrel and nozzle temperatures of the injection molding machine were set to 170°C and 180°C respectively, the temperature of the hot runner was se...

Embodiment 3

[0040] (1) Preparation of 10wt% HA / HDPE mechanical mixture: 10% HA and 90% HDPE were mechanically mixed with a high mixer for 20 minutes to make them evenly mixed.

[0041] (2) Preparation of 10wt% HA / HDPE melt mixture: the above mixture is placed in a twin-screw extruder for melt extrusion, and the extruder conveys the compression section, and the temperatures of the melting section and the metering section are respectively set to 170°C and 200°C, 190°C, the speed of the main engine is set at 120 rpm, and the speed of the feeding screw is 4 rpm, then the mixture is forced to cool and granulate, and dried under vacuum at 90°C until the water content is not higher than 0.01 of its own weight % obtained extruded material;

[0042] (3) Vibration injection molding: Vibration injection molding is performed on the above dried extruded pellets. The barrel and nozzle temperatures of the injection molding machine were set to 180°C and 180°C respectively, the temperature of the hot run...

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Abstract

The invention relates to an injection molding anisotropic bone substitute composite material and a preparation method thereof. The composite material is compounded by hydroxyapatite (HA) with biological activity and high-density polyethylene (HDPE) with biocompatibility in a vibration injection molding manner. The method comprises the following steps: (1) preparing an HA / HDPE mechanical mixture; (2) preparing an HA / HDPE melt mixture; and (3) carrying out vibration injection molding. According to the injection molding anisotropic bone replacement composite material, dispersion of HA in HDPE matrix is significantly improved; meanwhile, a large number of shish-kebab structures are formed in the HA / HDPE composite material in a vibration injection molding process; an anisotropic bionic structure with a similar natural bone tissue is obtained; the tensile property, the bending property and the impact strength are significantly improved; and the anisotropic bone substitute composite material is relatively suitable for being used as a human weight-bearing bone substitute material.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, in particular, the invention relates to an injection-molded anisotropic bone replacement composite material and a preparation method thereof. Background technique [0002] Bone tissue transplantation is a clinical allograft method second only to blood transfusion, and it is also an important treatment option for repairing bone defects. With the increase of average age and the diversification of lifestyle, the number of patients who need bone transplantation is increasing, and the advancement of medical technology makes patients hope to return to normal life through high-quality transplantation. The performance of the material puts forward higher requirements (G.K.Naughton, W.R.Tolbert, T.M.Grillot.Tissue Engineering.1995, 1:211~219.). High-density polyethylene (HDPE) is a biocompatible polymer material that has been approved by the U.S. Food and Drug Administration (FDA) for use in hu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/16A61L27/50
Inventor 李忠明王泽浦徐家壮徐玲黄妍斐
Owner SICHUAN UNIV
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