Bioabsorbable stent and preparation method thereof

A biodegradable polymer technology, applied in the field of medical devices, can solve the problems that droplets cannot cover the surface of the probe at one time, cannot carry drugs at one time, and it is difficult to position or limit the coating, so as to ensure process stability Sex, avoid permanent irritation, reduce the effect of loss of solution

Active Publication Date: 2015-05-27
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this spraying method, since the solution is sprayed onto the surface of the stent in an atomized state, the extremely small droplets cannot cover the surface of the probe at one time, resulting in the inability to carry a sufficient amount of medicine at one time. Usually, multiple or repeated spraying is required to achieve the purpose
In addition, the solution using this spraying method is uncontrollably and randomly scattered on the surface of the stent probe and the non-stent surface area, causing a large amount of waste of the solution, and it is difficult to position or limit the coating on the stent surface

Method used

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  • Bioabsorbable stent and preparation method thereof
  • Bioabsorbable stent and preparation method thereof
  • Bioabsorbable stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0057] The stent body 2 is made of bioabsorbable polylactic acid material (PLA), wherein the weight average molecular weight of the polylactic acid material ranges from 150,000 to 1,000,000 Daltons, and the degradable polymer of the surface coating 2 is made of poly D,L-lactide (PDLLA) material, with a weight average molecular weight ranging from 30,000 to 140,000 Daltons.

[0058] Take 0.4g of poly D,L-lactide polymer, add it into 10ml of n-propyl acetate solvent at room temperature to prepare a coating solution, after that, add 0.2g of rapamycin and mix evenly to form a coating solution, and coat the Layer solution is accurately sprayed to all parts of the outer surface of the stent body 2, and the stent structure formed refers to Figure 5 As shown, the scaffolds were left to dry at room temperature until use.

[0059] It should be noted that, according to the degradable time of the selected degradable polymer in the body and the amount of the polymer used, the poly-D, L-l...

Embodiment 2

[0061] The degradable materials used for the stent body 2 and the surface coating 3 are the same as those in Embodiment 1, and will not be repeated here.

[0062] Take 0.2g poly D,L-lactide polymer, add it into 10ml n-propyl acetate solvent at room temperature to prepare a uniform solution, then add 0.2g rapamycin and mix uniformly to form a coating solution. The coating solution is accurately sprayed onto the outer surface of the stent body 2 except for the connecting rod 22, and the formed stent structure refers to Figure 6 As shown, the scaffolds were left to dry at room temperature until use.

[0063] Similarly, the poly-D,L-lactide polymer used in this embodiment will degrade within 2 years after completing the drug release function, and the polylactic acid stent body 3 used will degrade within 3 years.

Embodiment 3

[0065] The degradable materials used for the stent body 2 and the surface coating 3 are the same as those in Embodiment 1, and will not be repeated here.

[0066] Take 0.2g poly D, L-lactide polymer, add it into 10ml n-propyl acetate solvent at room temperature to prepare a uniform solution, add 0.2g rapamycin and mix evenly to form a coating solution, and the coating solution is accurately Spot-coated onto the outer surface of the stent body 2, the surface coating 3 is in a discontinuous state, and the stent structure formed refers to Figure 7 As shown, the scaffolds were left to dry at room temperature until use.

[0067] Similarly, the poly-D,L-lactide used in this embodiment will degrade within 2 years after completing the drug release function, and the polylactic acid stent body 3 used will degrade within 3 years.

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Abstract

The invention relates to a bioabsorbable stent and a preparation method thereof. The preparation method comprises the steps of processing a degradable material into a tube; making the tube into a stent body by adopting a laser carving process, wherein the stent body comprises an inner surface and an outer surface and is a tubular structure formed by a plurality of connecting rods and a plurality of wavy pipes; coating solution is coated on at least part of the outer surface to form a surface coating layer. In the preparation method, the coating solution can be accurately coated at positions of the wavy rods or connecting rods on the outer surface so as to improve the utilization ratio of the solution and guarantee the process stability of the coating layer of the outer surface. Moreover, since the prepared bioabsorbable stent is prepared by using a bioabsorbable or biodegradable material, the stent can be fully degraded after medicine is released, the restenosis after stent implantation is reduced and the permanent stimulation to blood vessels is avoided.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a bioabsorbable bracket and a preparation method thereof. Background technique [0002] In recent years, bare metal stents and drug-eluting stents have been widely used for the treatment of coronary heart disease. Clinical data show that compared with bare metal stents, drug-eluting stents can effectively inhibit the proliferation of smooth muscle, significantly reduce the rate of stent restenosis and increase the rate of target vessel revascularization, and can reduce the rate of restenosis to 10% or even lower. Level. However, most of the stent bodies of bare stents and drug-eluting stents currently in mature use are non-degradable metal materials, which are permanently implanted devices. The long-term existence of these stents has permanent irritation to the vessel wall, increased long-term thrombosis risk, and long-term Intimal hyperplasia after implanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/91A61L31/06A61L31/16A61L31/14
Inventor 高雅琴孟娟张劼罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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