Plasma substitute medicine composition used in first aid and preparation method thereof

A composition and drug technology, applied in the field of blood plasma drug composition and its preparation, can solve the problems of renal dysfunction, nervous system disorder, blood cell rupture, cardiac insufficiency, etc., achieve low drug accumulation tendency, reduce edema, improve The effect of bleeding symptoms

Inactive Publication Date: 2015-05-27
PEKING UNIV FOUNDER GRP CO LTD +2
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hypertonic solutions such as 7.5% (w/v) sodium chloride and 7.2% sodium chloride, but this hypertonic concentration of sodium chloride has certain toxicity to the body and often leads to complications, such as hypotension, hypertonicity Blood cell rupture, cardiac insufficiency, renal insufficiency, and nervous sys

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Plasma substitute medicine composition used in first aid and preparation method thereof
  • Plasma substitute medicine composition used in first aid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0021] Example 1:

[0022] Preparation of Hydroxyethyl Starch 130 / 0.4 API: Amylopectin corn starch is used as the starting material, and it is obtained through hydrolysis, hydroxyethylation and refining.

Example Embodiment

[0023] Example 2:

[0024] Hydroxyethyl starch 130 / 0.4 6g

[0025] Sodium chloride 4.2 g

[0026] Add water for injection to 100ml

[0027] Dissolve the hydroxyethyl starch in water for injection, stir and heat at 90°C for 15 minutes, add sodium chloride and stir to dissolve, stir and heat at 90°C for 10 minutes, filter, fill, and sterilize to get it.

Example Embodiment

[0028] Example 3:

[0029] Hydroxyethyl starch 130 / 0.4 7g

[0030] Sodium chloride 2 g

[0031] Add water for injection to 100ml

[0032] Dissolve the hydroxyethyl starch in water for injection, stir and heat at 90°C for 15 minutes, add sodium chloride and stir to dissolve, stir and heat at 90°C for 10 minutes, filter, fill, and sterilize to get it.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a plasma substitute medicine composition used in first aid and a preparation method thereof. The plasma substitutes medicine composition includes 2-4.5% (w/v) of sodium chloride and 3-7% (w/v) of hydroxyethyl starch, wherein the average molecular weight of the hydroxyethyl starch is 130000 +/- 20000 Dolton. The plasma substitute medicine composition is strong in plasma volume expansion, is durable in effects, is low in tendency of medicine accumulation, is high in safety and is more less in influence on blood coagulation in human body. The plasma substitute medicine composition can be used for treating hemorrhagic shock due to various reasons and can be used for rescue of injury and burn patients. The plasma substitute medicine composition can be used in various operations.

Description

technical field [0001] The invention relates to a blood plasma replacement pharmaceutical composition for emergency use and a preparation method thereof, belonging to the technical field of pharmaceutical compositions. Background technique [0002] The traditional resuscitation of hemorrhagic shock is to use isotonic crystalloid and / or colloid fluid to infuse early, quickly, and in sufficient quantities, with the goal of restoring hemodynamics as soon as possible. ), and even developed into multiple organ dysfunction syndrome (MODS). Acute respiratory distress syndrome (ARDS) and MODS are currently the main causes of delayed death after resuscitation of trauma-hemorrhagic shock. Resuscitation methods that can reduce the inflammatory response and organ damage after resuscitation are the current focus of attention in the treatment of hemorrhagic shock. [0003] Compared with isotonic solutions, hypertonic solutions have the advantages of inhibiting the activation of neutroph...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K33/14A61K9/08A61P7/08A61K31/718
Inventor 易崇勤邹明琛郭欲晓谢小飞李育巧
Owner PEKING UNIV FOUNDER GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap