Asarin aerosol inhalant and preparation method thereof

Abstract

The invention provides an asarin aerosol inhalant and a preparation method thereof. The asarin aerosol inhalant is prepared from the following components in each liter of water for injection: 0.5-6 g of asarin, 1-100 g of an organic solvent, 1-30 g of a solubilizer, 0.01-0.2 g of a metal ion complexing agent, and an appropriate amount of a pH conditioning agent. The preparation method of the asarin aerosol inhalant comprises the following steps: dissolving the metal ion complexing agent into an appropriate amount of water to obtain a solution a; using the solvent to dissolve asarin, and then adding the solubilizer to obtain a solution b; mixing the solution a with the solution b to obtain a solution c; using the pH conditioning agent to regulate the pH value of the solution c, and then adding the balance of water to obtain the asarin aerosol inhalant. The aerosol inhalant disclosed by the invention is low in medication dosage, quick in taking effect, low in side effect, convenient to use, and effective in treatment, avoids the liver first pass effect, eliminates the pain of a patient, caused by injection administration, and improves the compliance of the patient.

Description

Technical field [0001] The present invention relates to the field of preparations of Asarone, in particular to an atomized inhalation of Asarone and a preparation method thereof. Background technique [0002] Asarone is one of the main active ingredients of the traditional Chinese medicine Acorus calamus. Its chemical name is 2,4,5-trimethoxy-1-propenylbenzene and its molecular formula is C. 12 H 16 O 3 , The molecular weight is 208.26. Asarum has various pharmacological effects such as relieving asthma, relieving cough, antispasmodic, antispasmodic, anticonvulsant and lowering blood lipids. It is clinically mainly used for respiratory tract infections, pneumonia, asthma, and epileptic seizures. At present, Asarum has been chemically synthesized, and the cost of medicine has been reduced, and its application has become more extensive. [0003] Currently on the market there are tablets, capsules and injections of asarone preparations. Due to poor water solubility and strong fat so...

AI Technical Summary

Problems solved by technology

[0005] The first object of the present invention is to provide a nebulized inhalation of asarone, compared with other preparations in the prior art, the aerosol inhalation of asarone not only greatly improves the curative effect and nebulization effect, And it also solves the problems of poor compliance and poor solubility of existing preparations

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