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Application of frankincense extract in prevention and treatment of gastric ulcer or enteritis

An extract, gastric ulcer technology, applied in the field of medicine, can solve the problems of no major breakthrough, serious cardiovascular adverse reactions, etc., and achieve the effects of low toxicity and side effects, protection of gastric mucosa, and prevention and treatment of non-specific ulcerative colitis

Inactive Publication Date: 2015-06-03
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The use of non-steroidal anti-inflammatory drugs (NSAIDs) is usually accompanied by gastrointestinal and cardiovascular side effects, and about one-third of patients taking long-term NSAIDs are accompanied by gastric or duodenal ulcers In the U.S. alone, the direct or indirect drug expenditures directly or indirectly related to the adverse reactions of NSAIDs exceed 7 billion U.S. dollars, and there is still no major breakthrough in the development of NSAIDs with small gastrointestinal and cardiovascular side effects
Despite the development of highly COX-2 selective drugs, their cardiovascular adverse effects are very serious

Method used

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  • Application of frankincense extract in prevention and treatment of gastric ulcer or enteritis
  • Application of frankincense extract in prevention and treatment of gastric ulcer or enteritis
  • Application of frankincense extract in prevention and treatment of gastric ulcer or enteritis

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Experimental program
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Effect test

preparation example Construction

[0014] Preparation of boswellia alcohol extract emulsion: Boswellia extract 10-30%, ethanol 1-5%, lecithin 10-30%, refined soybean oil 5-25%, oleic acid 0.5-6.5%, tocopherol 0.01-1.0% , Add physiological saline for injection to 100%.

[0015] Take 200 mg of frankincense extract, add 100 μl of absolute ethanol, 200 mg of refined soybean oil, 80 mg of oleic acid, and 1 mg of tocopherol, stir at 50°C at high speed to dissolve evenly, and make an oil phase; dissolve 200 mg of lecithin in an appropriate amount of physiological In the saline, stir at 50°C at high speed to dissolve it evenly to make the water phase; mix the oil and water two phases at 60°C and stir at high speed to make colostrum; add physiological saline for injection to 2mL, adjust the pH to 5.0-7.0, and make high pressure milk In a homogenizer, emulsify repeatedly until the average particle size of emulsion droplets is ≤0.5μm. Take the above-mentioned emulsion, filter it, fill it with nitrogen gas, and sterilize ...

Embodiment 1

[0020] Embodiment 1: above-mentioned emulsion stability investigation

[0021] The above-mentioned frankincense emulsion was placed at room temperature, high temperature and light, and the properties, pH value, insoluble particles and visible foreign matter were investigated on day 0, day 5 and day 10 respectively. The results are shown in Table 3, and the preparation was stable.

[0022]

Embodiment 2

[0023] Embodiment 2: the anti-ulcer effect investigation of above-mentioned emulsion

[0024] According to the above-mentioned gastric ulcer modeling method and scoring standard, the frankincense extract prevents and treats gastric ulcer experiment. The results are shown in Table 4, and the data values ​​represent P values ​​with mean ± standard deviation, afigure 1 shown. The results showed that among the three models, the difference in ulcer index between the 100mg / kg and 250mg / kg frankincense groups and the modeling group was statistically significant; while in the 50mg / kg group, the difference was statistically significant only in the cold stimulation modeling group , concluded that the 250mg / kg group had the most significant anti-ulcer effect.

[0025]

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PUM

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Abstract

The invention discloses an application of a frankincense extract in preparation of medicines for protecting and treating gastric ulcer and enteritis caused by kinds of factors. An in vivo study result on animals shows that the frankincense extract has the effects of protecting and treating anabrosis caused by kinds of stimulations such as alcoholic injures on gastric mucosa, non-steroidal anti-inflammatory drug damages and psychogenic stress damages, and treating enteritis; and an emulsion of the frankincense extract has the characteristics of high bioavailability, good validity and the like.

Description

technical field [0001] The invention relates to the application of frankincense extract in the preparation of medicines for preventing and treating gastric ulcer or enteritis, and belongs to the technical field of medicine. Background technique [0002] Gastric ulcer is a kind of peptic ulcer, which is a common clinical disease. According to reports, the probability of suffering from peptic ulcer in a person's life is about 10%. The typical feature of gastric ulcer is gastric mucosal injury, which can cause perforation in severe cases. The characteristic of gastric ulcer is periodic and chronic epigastric pain. The pain caused by gastric ulcer mostly occurs 0.5-1h after a meal, and the gastric acid is increased or normal. Mild symptoms include vomiting, nausea, and pain; severe symptoms may cause bleeding, shock, or even death. Both nonspecific ulcerative colitis and Crohn's disease are chronic diseases with many similarities. The symptoms are abdominal pain, diarrhea, an...

Claims

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Application Information

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IPC IPC(8): A61K36/324A61P1/04A61P1/00
Inventor 文爱东张一恺李玉文王明明丁一陈敏纯
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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